Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration by Daxue Zhu, Zhaoheng Wang, Shijie Chen, Yanhu Li, Xuewen Kang

“…Methods IVD samples were collected from patients undergoing spinal surgery and classified according to the Pfirrmann grading system. Human NP cells were cultured and treated with IL-1β to induce a pyroptotic phenotype. …”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

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Direction-Specific Signatures of Sport Participation in Center of Pressure Profiles of Division I Athletes by Stephen M. Glass, Scott E. Ross

“…# Background Descriptive and comparative studies of human postural control generally report effects for component or resultant dimensions of a measured signal, which may obscure potentially important information related to off-cardinal directionality. …”
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حکم‌روایی شهری و طبقۀ کارگر جهان سوم: برخی ملاحظات روش‌شناختی by حجت‌اله رحیمی

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Gastronomy vs gastro-anomie? Japan’s foodscape by А. V. Malov, S. V. Chugrov

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EXISTENTIAL CHOICE. AN ESSAY ABOUT THREE AFRICANS (REFLECTION ON AUGUSTINE’S CONFESSIONS) by S. V. Sannіkov

“…The use of other general scientific methods, such as analysis, reduction, generalization, and retrospective method allowed the researcher to highlight some epistemological problems manifested in understanding and searching the Truth, as the most important and often unconscious human need. Augustine's openness to accepting Truth from Above and at the same time understanding the inability to seize it independently distinguishes him from similar searches of Jacques Darrida. …”
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Official Development Assistance in Japan's Strategy in Central Asia by O. A. Dobrinskaya

“…Assisting economic development and helping settle security issues with an emphasis on human security projects demonstrate not only Japan’s desire to boost its positive image in the region but also enhance its international reputation and its vision of Central Asia as a ground for cooperation with other countries. …”
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College of American Pathologists (CAP)/American College of Medical Genetics and Genomics (ACMG) proficiency testing for urinary glycosaminoglycan analysis: A summary of performance by Kristina Cusmano-Ozog, Dietrich Matern, Thomas Long, Nicola Longo, Sarah Young

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Integração ou separação? Uma reflexão sobre a governança territorial no Prata a partir da construção da ponte da integração São Borja-Brasil/ Santo Tomé-Argentina by Muriel Pinto, Ronaldo Bernardino Colvero, Alex Sander Barcellos Retamoso

“…In this perspective the bridge emerges as a form of state control that does not prioritize human and cultural flows.…”
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Gallbladder Carcinomas: An Immunoprognostic Evaluation of P53; Bcl-2; CEA and Alpha-Fetoprotein by R Kanthan, JM Radhi, SC Kanthan

“…The p53 gene is the most frequently mutated gene in many human cancers, including those of the colon, breast, lung, esophagus, liver and brain. …”
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Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons by Lili Xie, Mao Mao, Liang Zhou, Lusi Zhang, Bing Jiang

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Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas. by Mengqing Mo, Can Hou, Huangbo Yuan, Renjia Zhao, Mingyang Chen, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Xingdong Chen, Chen Suo

“…Genome-wide association analysis (GWAS) was used to identify genetic susceptibility loci of SCCs. High resolution human leucocyte antigen (HLA) alleles and corresponding amino acid sequences were imputed using SNP2HLA and tested for association with SCCs. …”
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An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…This assay format provides unbiased analysis of morphological effects induced by small molecules by capturing phenotypic readouts of most known classes of pharmacological agents and has the potential to read out pathways for which little is known. Four human-cancer cell lines and one noncancerous primary cell type were treated with 107 small molecules comprising four different protein kinase-inhibitor scaffolds. …”
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Formulation and Development of a Water-in-Oil Emulsion-Based Luliconazole Cream: In Vitro Characterization and Analytical Method Validation by RP-HPLC by Vijay Kumar Panthi, Utsav Nepal

“…Moreover, without adding pH adjusting agents the pH of the optimized formulation (F5) was obtained within the range of human skin pH throughout the stability period. The value of particle size, polydispersity index, and zeta potential was 187.90 ± 2.061 nm, 0.124 ± 0.026, and -10.553 ± 1.349 mV, respectively. …”
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ART AS COMMUNICATION IN HOTSPOTS OF THE PLANET (ON THE EXAMPLE OF MODERN SYRIA). PART ONE by Oksana Kosiuk

“…It was found that painting turned out to be the most effective and relevant in Syria: it marked the beginning of the revolution of dignity in 2011 and so far has been recording crimes committed against humanity. Since no one has yet studied this aspect of communication, the goal was set to explore the visual arts of modern Syria as a means and method of communication with the help of structuralism (distinguishing the directions, methods and styles of modernism), semiotic and content analyzes (identifying symbolic units of communication), comparison (studying the process and experiences), modelling (defining the features of movements, directions and styles), etc. …”
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The effects of the image attributes of golf star athletes supported by adult amateur golfers on sports participation desire and continuation intention by Ji-Hye Yang, Ga Young Kim, Hye Jin Yang, Chulhwan Choi, Chul-Ho Bum

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Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells by Lidan Xue, Lili Huang, Yajing Tian, Xin Cao, Yu Song

“…TMAO was assessed in the serum and aqueous humor of patients using ELISA. Human retinal microvascular endothelial cells (HRMECs) were treated for 72 h as follows: NG (normal glucose, D-glucose 5.5 mM), NG + TMAO (5 μM), HG (high glucose, D-glucose 30 mM), and HG + TMAO (5 μM). …”
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Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation by Aaron L. Slusher, Tiffany M. Zúñiga, Edmund O. Acevedo

“…In addition, PBMCs were isolated from middle-aged and young adults to examine their capacity to express a key mechanistic component of telomere length maintenance, human telomerase reverse transcriptase (hTERT), following ex vivo cellular stimulation. …”
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Heart rate reserve effects on brain activation and cognitive-motor performance while doing an instrumented trail walking task in middle-aged to older adults by Alka Bishnoi, Manuel E. Hernandez

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Whole-Exome Sequencing Identifies One De Novo Variant in the FGD6 Gene in a Thai Family with Autism Spectrum Disorder by Chuphong Thongnak, Areerat Hnoonual, Duangkamol Tangviriyapaiboon, Suchaya Silvilairat, Apichaya Puangpetch, Ekawat Pasomsub, Wasun Chantratita, Pornprot Limprasert, Chonlaphat Sukasem

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