PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first‐pass metabolism? by Justine Henriot, André Dallmann, François Dupuis, Jérémy Perrier, Sebastian Frechen

“…To this end, a systematic review of the absolute CYP3A expression in the human gastrointestinal tract and liver was conducted. …”
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Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration by Aurélie Fessard, Aliki Zavoriti, Natacha Boyer, Jules Guillemaud, Masoud Rahmati, Peggy Del Carmine, Christelle Gobet, Bénédicte Chazaud, Julien Gondin

“…This method is commonly referred to as NeuroMuscular Electrical Simulation (NMES) in Human. Each NMES training session consisted of 80 isometric contractions delivered at ∼15% of maximal tetanic force to avoid muscle damage. …”
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An Efficient and Hybrid Deep Learning-Driven Model to Enhance Security and Performance of Healthcare Internet of Things by Muhammad Babar, Muhammad Usman Tariq, Basit Qureshi, Zabeeh Ullah, Fahim Arif, Zahid Khan

“…Sensors and actuators are used in smart medical devices to collect data about the human body, which is then sent to the fog layer for analysis. …”
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Effect of Green Roofs on the Thermal Environment of Prototype Broiler Houses by Maria Angela de Souza, Fernanda Campos de Sousa, Alex Lopes da Silva, Thauane Cordeiro Soares, Charles Paranhos Oliveira, Ricardo Brauer Vigoderis, Fernando da Costa Baêta, Ilda de Fátima Ferreira Tinôco

“…Parameters measured included air temperature, relative humidity, internal roof surface temperature, Temperature and Humidity Index (THI), Black Globe Humidity Index (BGHI), Human Comfort Index (HCI), and Thermal Radiation Load (TRL) under both open and closed conditions. …”
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Heart Rate Variability: A Psychophysiological Factor Related to Both Regular Physical Activity and Eudaimonic Well‐Being Among Young Adults by Yoshino Murakami, Daisuke Goto, Hayato Tsukamoto, Kazuho Yamaura, Takeshi Hashimoto

“…ABSTRACT Introduction Eudaimonic well‐being (EWB), which refers to optimal human functioning, is associated with psychophysiological outcomes, such as reduced inflammation and a lower risk of depression. …”
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Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p by Lei Xu, Gang Zhao, Hong Zhu, Shijun Wang, Aijun Sun, Yunzeng Zou, Junbo Ge

“…Induction with Rosiglitazone activated PPAR-γ and promoted its nuclear translocation in cultured human umbilical vein endothelial cells (HUVECs). …”
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Exploring household water conservation behaviors in Saudi Arabia: A structural equation modeling approach by Abdulaziz I. Almulhim, Ismaila Rimi Abubakar

“…Water conservation is crucial for human sustainable development, particularly in the face of increasing global challenges such as freshwater scarcity, rapid urbanization, and climate change. …”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…For EGFR-positive tumor targeting, humanized antigen-binding domains of therapeutic antibody cetuximab were used. …”
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Race to the Moon or the Bottom? Applications, Performance, and Ethical Considerations of Artificial Intelligence in Prosthodontics and Implant Dentistry by Amal Alfaraj, Toshiki Nagai, Hawra AlQallaf, Wei-Shao Lin

“…Regarding ethical issues, five studies identified concerns such as data privacy, system bias, and the potential replacement of human roles by AI. While patients generally viewed AI positively, dental professionals expressed hesitancy due to a lack of familiarity and regulatory guidelines, highlighting the need for better education and ethical frameworks. …”
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Application of Blockchain Technology in Carbon Trading Market: A Systematic Review by Timileyin P. Abiodun, Nnamdi I. Nwulu, Peter O. Olukanmi

“…The carbon trading system is a mechanism that employs carbon caps (limits) and taxation to regulate the rate of carbon dioxide emissions produced by human activities. To further strengthen the effectiveness of this mechanism, the United Nations (UN) initiated the Kyoto Protocol in 1997, enabling the trading of carbon emission rights in exchange for financial compensation. …”
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Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging by Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga

“…New in vitro binding data is also made available for (-)-FEOBV with human-sourced σ1 receptors, revealing a 300-fold stronger affinity for VAChT compared to σ receptors. …”
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Rehabilitation nursing for motor functional recovery of acute ischaemic stroke: study protocol for a randomised controlled trial by Yuanyuan Chen, Mei Li, Jianmiao Wang, Yuping Zhang, Jingfen Jin

“…We will recruit 224 patients within a period of 12–18 months from a hospital in southeastern China.Ethics and dissemination The study was approved by the Human Research Ethics Committee from the corresponding author’s hospital (approval Number is Ethical Review Study No. 2018 - 112). …”
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Evaluation of Sleep Disorders in the Elderly with Vestibular Vertigo by Zahra Hosseini Dastgerdi, Nasrin Gohari, Mobina Mehrabifard, Hasti Seifi, Bahare Khavarghazalani

“…Background: Vestibular vertigo and decreased sleep quality are prevalent issues that significantly affect the life expectancy, quality of life, and mental health of the elderly. Evidence from human and animal studies suggests a link between sleep disorders and vertigo. …”
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Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland by Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim

“…Lacrimal gland tumors, which occur at a very low frequency in the human population (1 per 1,000,000 per year), were detected in 7 cases of Brca1co/coMMTV-cre mice (2.75%) older than 9 months of age. …”
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Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow’s Milk Allergic Mice by Marlotte M. Vonk, Bart R. J. Blokhuis, Mara A. P. Diks, Laura Wagenaar, Joost J. Smit, Raymond H. H. Pieters, Johan Garssen, Léon M. J. Knippels, Betty C. A. M. van Esch

“…Both butyrate and FOS are promising candidates to improve OIT efficacy in human studies to treat food allergies.…”
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HIV and AIDS prevention behavior among housewives in South Purwokerto sub-district, Indonesia by Colti Sistiarani, Dian Anandari, Elviera Gamelia

“…Introduction Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a health problem associated with risky behavior. …”
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Pandemic-Induced changes in Travel Behaviour: Insights of Pandemic’s Lasting impacts on Lahore’s Urban Mobility by Hina Saleemi, Muhammad Momin Amer, Saadia Tabassum, Sadia Ismail

“… The COVID-19 epidemic, which began to spread globally in early 2020, created an abrupt change that has brought with it unimaginable challenges and profound adjustments to many elements and areas of human existence. This research delves into how the COVID-19 pandemic transformed travel patterns in Lahore, Pakistan.  …”
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An In Vitro Study of the Effects of Methotrexate Loaded Biocomposite Beads on MG63 Osteoblast Cells by A. E. Malash, A. A. Al-esnawy, Khairy T. Ereiba, Ahmed M. Bakr, A. S. Abdraboh

“…A cytotoxicity study of the methotrexate was performed by a human osteosarcoma (MG-63) cell line. Results indicated that the formation of a hydroxyapatite layer on the bead’s surface confirmed its biological activity. …”
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Attitudes towards Donor Breast Milk in an Inner City Population by Abhinav Pal, Kultida Soontarapornchai, Lawrence Noble, Ivan Hand

“…Education on the benefits of mother’s own milk as well as donor breast milk and milk banks is an important public health initiative needed to increase acceptance of human milk as the optimal form of nutrition in infants.…”
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Geoheritage and Geodiversity Assessment Framework for Practical Application to Geoconservation of the Coromandel Peninsula, New Zealand by Vladyslav Zakharovskyi, Karoly Nemeth, Ilmars Gravis, Chris Twemlow

“…Additionally, it will build a better understanding about the connections between abiotic and biotic factors in the environment, and human society within that environment. Here we provide a globally applicable method, using the Coromandel Peninsula as a case study. …”
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