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30541
ZEB1 as a marker of metastasis in thyroid carcinomas: review of literature and own data
Published 2024-11-01“…ZEB1 is the main EMT-TF of the ZEB family and is associated with cellular plasticity, dissemination, and the switch from a dormant to proliferative phenotype at distant metastatic sites and is a determinant of poorer clinical prognosis in most human cancers. ZEB1 is at the forefront of transcription factors involved in the EMT control and promotes tumor cell migration and diffusion, cell stemness, resistance to treatment, metastasizing and evasion of the immune response. …”
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30542
Polymorphism in the TRP8 gene in Kyrgyz population: putative association with highland adaptation
Published 2015-12-01“…The human TRPM8 gene encodes a receptor mediating cold sensitivity, and this fact points to its putative role in cold adaptation. …”
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30543
Adapting to change: exploring the distribution dynamics of the alien and potentially invasive aphid species Cinara curvipes (Hemiptera: Aphididae) in the context of global warming
Published 2025-12-01“…Unique survival mechanisms, including the production of numerous winged morphs under overcrowded conditions, enable rapid dispersal facilitated by human-mediated transport, notably through the “Christmas trees” trade. …”
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30544
Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species
Published 2025-01-01“…While it is impossible to give justice to all of these studies, this review provides a historical perspective on the major discoveries related to species differences in the biotransformation of AFB1 and sets the stage for discussion of other papers in this Special Issue of the important role that AFB1 metabolites have played as biomarkers of exposure and effect in thousands of human studies on the toxic effects of aflatoxins. …”
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30545
Comparison of Trace Elements in High-Molecular-Mass Multiprotein Complex and in Female Milk from Which It Was Obtained
Published 2019-01-01“…The analysis of the relative content of sixteen elements in human milk and oligomeric complexes of proteins was performed for the first time. …”
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30546
Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition
Published 2025-01-01“…In parallel studies, impaired ATP synthase assembly in human cells lacking TMEM242 prompted us to hypothesize that reduced ATP synthase could elevate reactive oxygen species (ROS) levels, influencing clotting factor expression. …”
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30547
Multisite Scenarios of Black Carbon and Biomass Burning Aerosol Characteristics in India
Published 2023-03-01“…Abstract Black Carbon (BC) aerosols are not only substantial climate-forcing drivers but also impact human health. The spatial distribution of BC aerosols depends on the combination of anthropogenic activities and meteorological conditions. …”
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30548
Stress and Coping Strategies among Students: Review
Published 2024-09-01“… <p>Global socio-economic crises, new pandemics, climate disasters, and other large-scale factors create an unfavorable background for humanity, often involving painful processes that lead to significant changes in personality and the social situation of development. …”
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30549
Birds of a feather? Mis- and dis-information on the social media platform X related to avian influenza
Published 2025-01-01“…Influenced by the recent announcement of a possible human death from H5N2 avian influenza, we analyzed tweets collected from X (formerly Twitter) to describe the messaging regarding the HPAI outbreak, including mis- and dis-information, concerns, and health education. …”
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30550
Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China
Published 2025-01-01“…Abstract Human brucellosis is a re-emerging disease in Sichuan Province, China. …”
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30551
Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2
Published 2025-02-01“…Background: Yiqi Fumai Lyophilized Injection (YQFM) is a plant-derived preparation that shows protective effects against cardiac dysfunction in both human and animal models. In heart failure (HF), proteins involved in Ca2+ regulation, such as sarcoplasmic/endoplasmic reticulum Ca2+ transporting protein 2 (SERCA2) and cardiac ryanodine receptor 2 (RyR2), are dysfunctional. …”
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30552
Public attitudes and knowledge about self‐injury: A cross‐sectional web‐based survey of Japanese adults
Published 2024-12-01“…Younger participants were more likely to believe that self‐injury is solely for stimulation than other age groups. Those with human‐service professional experience were more likely to view self‐injury as attention‐seeking compared to those without such experience (AOR = 1.62, 95% CI = 1.07–2.46). …”
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30553
Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents
Published 2017-09-01“…Most of the newly synthesized compounds were evaluated for their in vitro activity against three human tumor cell lines, namely, liver cancer (HepG-2), colon cancer (HT-29) and lung cancer (NCI-H460), using doxorubicin as standard. …”
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30554
STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines
Published 2025-01-01“…IL-4, rather than IL-13, activated STAT6 in human pulmonary artery smooth muscle cells (hPASMCs). …”
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30555
Emission Characteristics and Health Risk Assessment of Volatile Organic Compounds in Key Industries: A Case Study in the Central Plains of China
Published 2025-01-01“…Volatile organic compounds (VOCs), the precursors of ozone and fine particulate matter, are one of the atmospheric pollutants harmful to human health. The emission characteristics of VOCs in Anyang, a typical industrial city in the Central Plains of China, are unclear. …”
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30556
AirStrum: A virtual guitar using real-time hand gesture recognition and strumming technique
Published 2024-12-01“…Finally, the proposed system can play different sounds by inferring both the played chord and the strumming velocity from human actions. This comprehensive approach enables a sophisticated virtual guitar experience based on a system that responds dynamically to the users' gestures and strumming techniques. …”
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30557
Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats
Published 2025-01-01“…The EndMT cell model was established via human umbilical vein endothelial cells (HUVECs), and the RHD animal model was established via female Lewis rats. …”
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30558
Validation and accuracy of the Hyfe cough monitoring system: a multicenter clinical study
Published 2025-01-01“…The time stamps of these human-detected coughs were compared to those of the CoughMonitor to determine the system’s overall performance using event-to-event and hourly rate correlation analyses. …”
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30559
Rebuilding Soil Ecosystems for Improved Productivity in Biosolarized Soils
Published 2019-01-01“…While biosolarization offers an organic option for soil pest control and avoids human and environmental health risks associated with chemical fumigants, it still has broad negative impacts on microbial communities. …”
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30560
Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict...
Published 2024-01-01“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. …”
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