Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1 by Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang

“…This study aims to explore the relationship between GaMSC derived exosomes (GAMSC-EXO) and PDHA1, as well as the effects and mechanisms on GBM glucose metabolism. In this study, human GaMSC-derived exosomes were isolated and identified. …”
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Antioxidant Bio-Compounds from Chestnut Waste: A Value-Adding and Food Sustainability Strategy by Roberta Barletta, Alfonso Trezza, Andrea Bernini, Lia Millucci, Michela Geminiani, Annalisa Santucci

“…Furthermore, the cytotoxicity assay demonstrated the safety of all three extracts in the tested human cell lines. In silico docking simulations further validated the biological relevance of these compounds by predicting strong hydrophobic and polar interactions with oxidative stress-related protein targets. …”
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Closing the loop: establishing an autonomous test-learn cycle to optimize induction of bacterial systems using a robotic platform by Jan Benedict Spannenkrebs, Aron Eiermann, Thomas Zoll, Silke Hackenschmidt, Johannes Kabisch, Johannes Kabisch, Johannes Kabisch

“…As a result, even in times of rapidly advancing artificial intelligence, the common design-build-test-learn (DBTL) cycle is still not circular without human intervention. To move towards fully automated DBTL cycles, we developed a software framework to enable a robotic platform to autonomously adjust test parameters. …”
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O IMPERATIVO EMOCIONAL SOB A HIPÓTESE DOS MARCADORES SOMÁTICOS E SUA RAMIFICAÇÃO SOMÁTICO-BIOLÓGICA NA REGULAÇÃO DA TOMADA DE DECISÃO NO ERRO DE DESCARTES by Matheus dos Reis Gomes

“… Neste artigo, buscamos descrever o papel crucial da hipótese dos marcadores somáticos (HMS) na interação entre o que denominamos de ‘imperativo emocional’ e a ingerência da razão durante o processo de tomada de decisão na obra Descartes’ Error: Emotion, Reason, and the Human Brain, de António Damásio. Primeiramente, examinamos a interação entre raciocínio, emoções e ação humana, com ênfase nos processos cognitivos subjacentes à tomada de decisão. …”
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Cetacean feeding modelling using machine learning: A case study of the Central-Eastern Mediterranean Sea by Carla Cherubini, Giulia Cipriano, Leonardo Saccotelli, Giovanni Dimauro, Giovanni Coppini, Roberto Carlucci, Carmelo Fanizza, Rosalia Maglietta

“…Investigating environmental drivers of cetacean feeding behaviour is essential for effective marine resource management, especially in the Mediterranean Sea, a biodiversity hotspot heavily impacted by human activities and climate change. This study realized a pioneer assessment of feeding activity related to the marine environment for three cetacean species - striped dolphin, common bottlenose dolphin, and Risso's dolphin - in the Gulf of Taranto (Northern Ionian Sea, Central-eastern Mediterranean) using an innovative Machine Learning (ML) approach. …”
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Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population by O. Bulgakova, A. Kussainova, A. Kakabayev, А. Kausbekova, R. Bersimbaev

“…However, the effect of radon on human health in the Republic of Kazakhstan is almost unknown. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Transcriptome analysis using RNA-sequencing (RNA-Seq) revealed that AIM2 was significantly downregulated in primary human RPE (phRPE) cells undergoing EMT and proliferation. …”
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Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods by Jangwoo Lee, Kevin Xiang, Emily Au, Shahrzad Sarabi, Nicole Acosta, Srijak Bhatnagar, Jennifer Van Doorn, Stefania Bertazzon, John M. Conly, Elissa Rennert-May, Johann D. D. Pitout, Bonita E. Lee, Xiaoli Pang, Christine O’Grady, Kevin Frankowski, Casey R. J. Hubert, Michael D. Parkins

“…These were compared with sewage metagenomes from 244 cities around the world, linked with Human Development Index (HDI). Results Wastewater metagenomes from Calgary’s socioeconomically diverse neighborhoods exhibit highly similar resistomes, with no quantitative differences (p > 0.05), low Bray-Curtis dissimilarity, and no significant correlations with SES. …”
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1-Bit/2-Level Analog-to-Digital Conversion Based on Comparator and FPGA for Aperture Synthesis Passive Millimeter-Wave Imager by Xiangzhou Guo, Ghulam Mehdi, Muhammad Asif, Anyong Hu, Jungang Miao

“…An aperture synthesis passive millimeter-wave (PMMW) imager is under development at Beihang University, which is designed for concealed contraband detection on the human body in an indoor environment. This imager uses 256 antenna-receiver channels with 1 GHz bandwidth and can obtain a radiometric sensitivity less than 1 K at a video imaging rate (&#x007E;25 frame/s). …”
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Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage by Marin Kuntić, Ivana Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Dilja Krueger-Burg, Huige Li, Sebastian Steven, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber

“…This study provides a novel perspective mitigating the adverse effects of noise pollution, especially in vulnerable groups with medication, a rationale for further pharmacological human studies.…”
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It’s safe to move! A protocol for a randomised controlled trial investigating the effect of a video designed to increase people’s confidence becoming more active despite back pain... by Ian A Harris, Adrian C Traeger, James H McAuley, Siobhan M Schabrun, Benedict Martin Wand, Aidan Cashin, Christopher Michael Williams, Edel O'Hagan, Sean O'Neill

“…We obtained ethical approval from our institutions Human Research Ethics Committee before data collection. …”
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Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model by Robert Ossendorff, Sarah Kurth, Su Wang, Max Jaenisch, Elio Assaf, Sebastian Scheidt, Kristian Welle, Christof Burger, Dieter C. Wirtz, Andreas C. Strauss, Frank A. Schildberg

“…Titration of IL-1β (100–0.1 ng/mL) was performed with both human and bovine recombinant protein in chondrocyte culture for 2 weeks. …”
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Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

“…In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor 2 (eIF2α), can induce apoptosis of human adrenocortical carcinoma (ACC) cell via activating the PERK/eIF2α/ATF4 signaling pathway, and the potential mechanisms of this action were explored. …”
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Zero-Shot Remote Sensing Scene Classification Based on Automatic Knowledge Graph and Dual-Branch Semantic Correlation Supervision by Chao Wang, Jiajun Yang, Tanvir Ahmed, Yang Zhao, Tong Zhang, Bing Sun, Tao Xie, Jie Wang, Tianyu Chen

“…However, current graphs rely heavily on expert manual interpretation, making them susceptible to human biases and difficult to expand. They also lack quantitative description of the degree of spatial relationship associations and fail to adequately represent semantic information. …”
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Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis by Zhiyong Wan, Meng Cui, Jia Yang, Dan Liao, Junliang Chen, Fanmin Li, Yin Xiang, Zhiwei Cui, Yang Yang

“…Therefore, we conducted a meta-analysis to evaluate its prognostic value in human cancers.MethodsPRISMA reporting guidelines were strictly followed for conducting the current meta-analysis. …”
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Classification of Cigarette Types Using Computer Vision: An Analysis of Smoke Aggregation Features by Shishuan Guan, Lei Jiao, Zengyu Wang, Xiaofei Ji, Hongwei Zheng, Cunfeng Yu, Hongtao Li, Liwen Zheng, Shuaishuai Sun, Qiang Sun, Jun Li, Guangwei Jiang, Kezhi Wu, Erge Lin, Xinlong Zhang

“…Firstly, we constructed a 3D model experimental platform based on the human upper respiratory tract to create the cigarette smoke image dataset SmogAg. …”
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SVR model and OLCI images reveal a declining trend in phycocyanin levels in typical lakes across Northeast China by Changchun Song, Yipei Xu, Chong Fang, Chi Zhang, Zhuohang Xin, Zhihong Liu

“…Recently, the frequency of cyanobacterial blooms in lakes across Northeast China has noticeably increased, because of the combined effect of global climate change and human activities. Phycocyanin (PC), a distinctive pigment found in cyanobacteria, plays a pivotal role in detecting and predicting harmful cyanobacterial blooms. …”
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Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…PTX-loaded VD3 micelles also exhibited prominent cell internalization and induced a considerable cytotoxic synergistic effect against human PDAC cells (BxPC-3 cells) in 2D and 3D cell culture models compared with free PTX. …”
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Rice stable carbon and nitrogen isotope values as potential indicators of watering and manuring regimes by Rubi Wu, Rubi Wu, Eric J. Belfield, Yu Dong, Shangzong Feng, Xiangdong Fu, Nicholas P. Harberd, Fan Yang, Michael Charles, Amy Bogaard

“…Previous research on early rice in the Lower Yangtze River basin (LYRB) suggested shifts back and forth over time between wet and dry field conditions, and some application of animal dung and/or human feces as fertilizer. In this study, stable carbon and nitrogen isotope analysis was conducted on grains from rice of heritage landraces and modern varieties grown in a glasshouse pot experiment with three watering levels and two manuring levels, and from recent rice fields in China and South Korea including paddy and dry conditions, and with variable manuring histories. …”
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Structural, Optical, Antibacterial, and Anticancer Properties of Cerium Oxide Nanoparticles Prepared by Green Synthesis Using Morinda citrifolia Leaves Extract by Abozer Y. Elderdery, Badr Alzahrani, Abdulrahim A. Alabdulsalam, Siddiqa M. A. Hamza, Ahmed M. E. Elkhalifa, Abdulaziz H. Alhamidi, Fehaid Alanazi, A. Mohamedain, Suresh Kumar Subbiah, Pooi Ling Mok

“…The anticancer properties of the green synthesized CeO2 NPs against human acute lymphoblastic leukemia (ALL) MOLT-4 cells were further explored by the meticulous study of their ability to diminish cancer cell viability (cytotoxicity), accelerate apoptosis, escalate intracellular reactive oxygen species (ROS) accumulation, decline the mitochondria membrane potential (MMP) level, modify the cell adhesion, and shoot up the activation of proapoptotic markers, caspase−3, −8, and −9, in the tumor cells. …”
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