Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization by Alejandro Alvarez-Arce, Irene Lee-Rivera, Edith López, Arturo Hernández-Cruz, Ana María López-Colomé

“…Due to the irreversible nature of PAR1 activation, its inactivation must be efficiently regulated in order to terminate signaling. Using ARPE-19 human RPE cell line, we characterized thrombin-induced [Ca+2]i increase and demonstrated the calcium-dependent activation of μ-calpain mediated by PAR1. …”
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Comparative immobilization of lead, cadmium, and copper in soil using dead bacterial biomass and graphitic carbon nitride nanomaterials by Asifa Farooqi, Ejaz ul Haq, Hooria Ikram Raja, Hafiz Abdul Malik, Yousaf Shad Muhammad, Syed Hamza Safeer, Sohail Yousaf, Maximilian Lackner

“…Heavy metals (HM) are known to pose severe harm to the soil, crops, and human beings. The usefulness and efficiency of metal immobilization of Pb, Cd, and Cu ions using different doses of dead bacterial biomass (BM) and graphitic carbon nitride (g-C3N4) was evaluated and compared in spiked soil. …”
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γ-H2AX: A Novel Prognostic Marker in a Prognosis Prediction Model of Patients with Early Operable Non-Small Cell Lung Cancer by E. Chatzimichail, D. Matthaios, D. Bouros, P. Karakitsos, K. Romanidis, S. Kakolyris, G. Papashinopoulos, A. Rigas

“…The use of artificial neural networks in prediction problems is well established in human medical literature. The aim of the current study was to assess the prognostic value of a series of clinical and molecular variables with the addition of γ-H2AX—a new DNA damage response marker—for the prediction of prognosis in patients with early operable non-small cell lung cancer by comparing the γ-H2AX-based artificial network prediction model with the corresponding LR one. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. Of particular concern are Candida auris, the Candida haemulonii complex (which includes C. haemulonii sensu stricto, C. duobushaemulonii and C. haemulonii var. vulnera), and phylogenetically related species, including C. pseudohaemulonii and C. vulturna. …”
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Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein. by Qian Qiu, Zihan He, Jing Liu, Huijun Xu, Jinyu Wang, Nannan Liu, Ning Kang, Shaokun Pan, Weien Yu, Zixiang Gao, Shimei Zhang, Yang Yang, Qiang Deng, Youhua Xie, Jiming Zhang, Zhongliang Shen

“…Finally, HBV infection is significantly suppressed by MSX1 overexpression in both NTCP-overexpressing cell and humanized liver mouse models. These results demonstrate additional and novel mechanisms of MSX1-mediated repression of HBV, and establish MSX1 as a multi-functional HBV restriction factor with therapeutic potential.…”
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Topical Issues of Improving the Activities of Police Commissions of the National Police of Ukraine by K. L. Buhaichuk

“…Based on the analysis of the basic law regulating the activities of the National Police of Ukraine, as well as the regulatory acts of the Ministry of Internal Affairs of Ukraine, propositions were formulated aimed at improving the procedure for the activities of police commissions, in particular regarding: optimization of the system of police commissions, determining the procedure and grounds for creating several commissions in territorial police agencies; improving the procedure for nominating candidates to police commissions from the Minister of Internal Affairs, the Head of the National Police and the Commissioner for Human Rights of Verkhovna Rada of Ukraine; depoliticizing the staff of police commissions; establishing a clear algorithm for the activities of police commissions to determine the priorities of police activities; improving the procedure for conducting interviews with candidates for positions and the procedure for assessing such interviews; establishing administrative responsibility for interfering with the work of police commissions.…”
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Elucidating the role of carrier proteins in cytokine stabilization within double emulsion‐based polymeric nanoparticles by Emily R. Rhodes, Nicole B. Day, Emma C. Aldrich, C. Wyatt Shields IV, Kayla G. Sprenger

“…We investigated protein–protein interactions between human (h)IL‐12 and albumin and simulated these components in pure water, dichloromethane (DCM), and along a water/DCM interface to replicate the solvent regimes formed during double emulsification. …”
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Reconstruction of Alzheimer’s Disease Cell Model In Vitro via Extracted Peripheral Blood Molecular Cells from a Sporadic Patient by Sijun Liu, Yuying Zhao, Xiaoying Su, Chengcheng Zhou, Peifen Yang, Qiusan Lin, Shijun Li, Hanxu Tan, Qi Wang, Changjun Wang, Qingguang Wu

“…The establishment of human-induced pluripotent stem cell (iPSC) models from sporadic Alzheimer’s disease (sAD) patients is necessary and could potentially benefit research into disease etiology and therapeutic strategies. …”
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Cadaveric Study of Variations in the Course of Lateral Femoral Cutaneous Nerve: Insight to Prevent Injury by Nidhi MANGLA, Surbhi WADHWA, Sabita MISHRA, Sumit SURAL, Neelam VASUDEVA

“…Methods: Twenty five adult human formalin embalmed cadavers were dissected. …”
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Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy by Nie Zhang, Zhuoying He, Xuejin Qin, Ke Han, Zhengchun Zhu, Fei Zhong

“…This study aimed to elucidate the role of CENPN in human cancers and evaluate its prognostic significance. …”
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A maturity model for Clinical Trials Management Ecosystem by Shruti Sehgal, E. Chris Pua, Svetlana Rojevsky, Michael J. Becich, Joshua Fehrmann, Boyd M. Knosp, Adam Wilcox, Jeffery C. Talbert, Catherine K. Craven, Justin Starren

“… Abstract Introduction: Managing clinical trials is a complex process requiring careful integration of human, technology, compliance, and operations for success. …”
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Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease by Junhua Huang, Shuwan Zhang

“…We observed that serum vascular endothelial growth factor (VEGF) levels were increased in KD patients and sera from KD patients upregulated the expression of VEGF receptor 2 (VEGFR2) and neuropilin-1 (NRP1) in human coronary artery endothelial cells (HCAECs). …”
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Institute of higher education: the first quarter of a century by Василь Кремень

“…First, the development of higher education stimulated the formation of a young Ukrainian state, ensured the establishment of norms and values characteristic of a democratic state, and the development of the best qualities of human capital in Ukraine. Secondly, it was necessary to carry out radical changes in the entire system of higher education of Ukraine, to create a coherent national and modern system of higher education, which involved not only the implementation of changes at the national level, but also a significant restructuring of the universities themselves. …”
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Esthetical Properties of Single-Shade and Multishade Composites in Posterior Teeth by Graziela R. Batista, Alessandra B. Borges, Rayssa F. Zanatta, Cesar R. Pucci, Carlos R. G. Torres

“…For that, 23 extracted human molars were used. The shade determination was performed, and the occlusal anatomy was registered by a custom-made stamp. …”
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Optimized Adaptive Neuro-Fuzzy Inference System Using Metaheuristic Algorithms: Application of Shield Tunnelling Ground Surface Settlement Prediction by Xinni Liu, Sadaam Hadee Hussein, Kamarul Hawari Ghazali, Tran Minh Tung, Zaher Mundher Yaseen

“…Deformation of ground during tunnelling projects is one of the complex issues that is required to be monitored carefully to avoid the unexpected damages and human losses. Accurate prediction of ground settlement (GS) is a crucial concern for tunnelling problems, and the adequate predictive model can be a vital tool for tunnel designers to simulate the ground settlement accurately. …”
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Development of a Combined 2D-MGD TLC/HPTLC Method for the Separation of Terpinen-4-ol and α-Terpineol from Tea Tree, <i>Melaleuca alternifolia</i>, Essential Oil by Aimé Vázquez, Nurhayat Tabanca

“…This study showcases a combined 2D-MGD TLC/HPTLC method for the successful separation of TTO components of interest. While human error, limited separation, and the partial evaporation of volatile components may still present a challenge during the process, considerable recovery of mono- and sesquiterpenes was achieved. …”
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Biochemical Investigation into the Benefit of Quercetin Supplementation in Hypoxic Mice by Otomewo LO, Anthony TE, Moke EG, Onohwosafe J

“… Context: Since the proper flow of oxygen into the human body signifies one of the core features of living organisms, a shortage in supply poses a significant threat to survival. …”
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Acridine-2,4-Dinitrophenyl Hydrazone Conjugated Silver Nanoparticles as an Efficient Sensor for Quantification of Mercury in Tap Water by Imdad Ali, Ibanga Okon Isaac, Mahmood Ahmed, Farid Ahmed, Farhat Ikram, Muhammad Ateeq, Rima D. Alharthy, Muhammad Imran Malik, Abdul Hameed, Muhammad Raza Shah

“…In this context, mercury is a highly dangerous metal which poses serious impact on human health. In the present study, acridine- (ACR-) based silver nanoparticles (ACR-AgNPs) were prepared and employed as a nanosensor for effective detection and quantification of Hg2+ in tap water. …”
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Alkali metal salt modulated visible photocatalytic degradation of tetracycline hydrochloride by g-C3N4: Degradation pathway, mechanism and toxicity assessment by Yujie Jiao, Sujin Lu, Ru Li, Qikai Liu, Yongxia Ma, Fei Fu, Yaqi Mao, Yang Liu

“…The frequent occurrence of tetracycline antibiotics in natural water systems poses a substantial risk to aquatic ecosystems and human health. Achieving efficient degradation of tetracyclines in aqueous environments using visible light is therefore of critical importance. …”
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Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining by Kristian Kjærgaard, Chris H. Dreyer, Nicholas Ditzel, Christina M. Andreasen, Li Chen, Søren P. Sheikh, Søren Overgaard, Ming Ding

“…Origin of new bone was assessed using human vimentin (HVIM) antibody staining. Results. …”
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