Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro. …”
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Antimicrobial Activity and Mode of Action of N-Heterocyclic Carbene Silver(I) Complexes by Giusy Castagliuolo, Michela Di Napoli, Tshering Zangmo, Joanna Szpunar, Luisa Ronga, Anna Zanfardino, Mario Varcamonti, Diego Tesauro

“…Silver drugs have played a vital role in human healthcare for the treatment of infections for many centuries. …”
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LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis, Helen Gika

“…<b>Results:</b> BµS devices, especially Mitra and Capitainer, provided equal or even superior information on the metabolic profiling of human blood based on the number and intensity of features and the precision and stability of some annotated metabolites compared to plasma. …”
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Exploring the operator experience in automated shuttles: Fatigue, attention, and gaze behaviour by Christer Ahlström, My Weidel, Anna Sjörs Dahlman, Ashleigh Filtness, Anna Anund

“…Automated shuttles provide a first look at future transportation, however, they still require on-board human operators for regulatory compliance and safety assurance. …”
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Effect of Chlorhexidine Treatment on Microleakage of Glass Ionomer, Giomer and Methacrylate-Based Composite Restorations in Class V Cavities by Ayşe Aslı Şenol, Seda Özmen, Büşra Karabulut Gençer, Bilge Tarçın, Pınar Yılmaz Atalı

“… Purpose: The aim of this in vitro study was to evaluate the effect of material selection and chlorhexidine digluconate (CHX) pretreatment on microleakage in Class V cavities restored with 3 different restorative materials.Materials and Methods: Thirty freshly extracted sound human molars were cleaned and stored in distilled water. …”
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A multimodal multistream multilevel fusion network for finger joint angle estimation with hybrid sEMG and FMG sensing by Zhouping Chen, Mohamed Amin Gouda, Longcheng Ji, Hong Wang

“…Finger joint angle (FJA) estimation, as a dynamic and fine-grained decoding mode, can support intuitive and natural human–machine interactions. This study is pioneering work dedicated to achieving accurate and clinically friendly FJA estimation. …”
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Users’ experiences of an online intervention for bipolar disorder: important lessons for design and evaluation by Richard Morriss, Steven H Jones, Fiona Lobban, Alyson L Dodd, Sara Mallinson, Martin Griffiths

“…Individual preferences and human contact were key factors for both trial design and engagement with an online intervention.Clinical implications Digital interventions should be co-produced, personalised, interactive and embedded as one component in a broader package of care.Trial registration number ISRCTN56908625; Post-results.…”
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease by Yong Hui Nies, Wei Ling Lim, Norwahidah Abd Karim, Mohamad Fairuz Yahaya, Seong Lin Teoh

“…This study explores the neuroprotective potential of exogenous human metallothionein 2 (hMT2) peptide in a rotenone-induced PD zebrafish model.MethodsAdult zebrafish were divided into four groups: control, rotenone-treated, hMT2 pre-treatment, and hMT2 co-treatment. …”
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Analysis of Melanin Concentration on Reflective Pulse Oximetry Using Monte Carlo Simulations by Maximilian Reiser, Oliver Amft, Andreas Breidenassel

“…We conclude that skin tone-adapted calibration should be applied to make reflective pulse oximeter applicable to any human, independent of skin pigmentation.…”
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Estimation of translational importance of mammalian mRNA nucleotide sequence characteristics based on ribosome profiling data by O. A. Volkova, Yu. V. Kondrakhin, R. N. Sharipov

“…A statistical analysis was carried out for revealing relationships between the human and mouse mRNA nucleotide sequence characteristics and ribosome profiling data. …”
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Landscape connectivity alters the evolution of density-dependent dispersal during pushed range expansions by Dahirel, Maxime, Bertin, Aline, Calcagno, Vincent, Duraj, Camille, Fellous, Simon, Groussier, Géraldine, Lombaert, Eric, Mailleret, Ludovic, Marchand, Anaël, Vercken, Elodie

“…As human influence reshapes communities worldwide, many species expand or shift their ranges as a result, with extensive consequences across levels of biological organization. …”
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Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells by Zamaneh Hajikhezri, Ioannis Zygouras, Anders Sönnerborg, Robert van Domselaar

“…Moreover, cytokine-primed but not resting human primary NK cells exhibited LRA activity that could be neutralized with LTα neutralizing antibodies. …”
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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…Xenograft studies showed that the efficacy of CAB bispecific antibodies is similar to that of a non-CAB anti-EpCAM bispecific antibody, but they have markedly reduced toxicity in non-human primates, indicating an unprecedentedly widened therapeutic index of over 100-fold. …”
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Thinking through the tool: collaborative archaeological bodywork in immersive virtual reality by Giles Spence Morrow, Steven A. Wernke

“…This paper considers how the scale at which the human body interacts with immersive digital models is especially important for understanding the affordances and ergonomics of past things and places. …”
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Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles by Xi Tang, Jingke He, Qin Huang, Yi Chen, Ke Chen, Jing Liu, Yingyu Tian, Hui Wang

“…Grade, International Federation of Gynecology and Obstetrics (FIGO) stage, platelet-to-lymphocyte ratio, red blood cell distribution width-coefficient of variation, triglycerides, and human epididymal protein 4 were identified as independent prognostic factors. …”
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Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells by Mohammad Alenizy, Abdullah Alhussein, Nader Almutairi, Ibrahim Ba-Armah, Tao Ma, Suping Wang, Nageswara R. Pilli, Maureen A. Kane, Michael D. Weir, Abraham Schneider, Hockin H. K. Xu

“…This study aimed to: (1) develop a calcium phosphate cement with chitosan (CPCC) with improved physio-mechanical properties; (2) incorporate metformin (CPCC-Met) to assess release; and (3) evaluate human dental pulp stem cells (hDPSCs) response. CPCC was mixed at different powder-to-liquid ratios to evaluate physio-mechanical properties compared to MTA. …”
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Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome by Yizhao Luan, Peng Li, Yuanyuan Luo, Hong Zhang, Xiaochun Zhu, Yan Zhang, Aihua Yin, Qiang Wu, Chengwei Chai

“…On the one hand, leveraging human single-cell atlas for developing enteric nervous system, we demonstrated that some affected genes in these two patients overlapped with those showing expression changes along the development pseudotime of enteric nervous cells (ENC) and overlapped with known HSCR genes including RET, NRG1, ERBB (ERBB2 and ERBB3), ITGB (ITGB1). …”
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Degree of corrosion and other deterioration effects in highway bridge deck component using non-destructive self potential and vibration testing: case study from SW Nigeria by O. O. Falowo, O. Makinde, Y. Akindureni

“…Therefore, based on suspected human perception, the Ogbese highway bridge stability was investigated using non-destructive half-cell method and vibration measurement. …”
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A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala by Santhosh N. Hegde, Lavanya Devi K, Mahima Choudhary, Nandita Menon, Gurmeet Singh

“…Additionally, five common polyphenols showed potential human targets related to antioxidant activity. These findings provide a deeper understanding of the phytochemical diversity and potential health benefits of Triphala, supporting its traditional use in promoting health.…”
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Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study by Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Guoqiang Gu, Wei Cui

“…Hypertension poses a major threat to human health, and inflammation is associated with hypertension. …”
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