IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…The expression of IRF-1 in human PBMC-derived macrophages was analyzed. Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…This study investigated the anti-inflammatory effects of human umbilical cord-derived MSC (hUCSC)-EVs overexpressing miR-124 in collagen-induced arthritis (CIA). hUCSCs were transfected with miR-124, and hUCSC-EVs were isolated and characterized. …”
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AutoMEX: Streamlining material extrusion with AI agents powered by large language models and knowledge graphs by Haolin Fan, Junlin Huang, Jilong Xu, Yifei Zhou, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…AutoMEX utilizes a knowledge graph (KG) derived from the scientific literature to enable LLMs to provide expert recommendations on material selection, process parameters, and design considerations, thereby improving accessibility and efficiency. With minimal human intervention, the framework encompasses a complete workflow, including CAD model generation, printing parameter recommendation, slicing, and machine operation. …”
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A novel Complex q-rung orthopair fuzzy Yager aggregation operators and their applications in environmental engineering by Jabbar Ahmmad, Tahir Mahmood, Dragan Pamucar, Hafiz Muhammad Waqas

“…Improving human health and comfort in buildings requires efficient temperature regulation. …”
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Adiabatic Fixed-Bed Gasification of Colombian Coffee Husk Using Air-Steam Blends for Partial Oxidation by Javier Bonilla, Gerardo Gordillo

“…The increasing energy consumption, mostly supplied by fossil fuels, has motivated the research and development of alternative fuel technologies to decrease the humanity’s dependence on fossil fuels, which leads to pollution of natural sources. …”
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Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model by Gemala Anjani, Reza Achmad Maulana, Sylvia Rahmi Putri, Faizah Fulyani, Ahmad Syauqy, Diana Nur Afifah, Fitriyono Ayustaningwarno, Refani Alycia Kusuma, Zulfatul Masruroh

“…Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. …”
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Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn by Ruichun Yang, Yunfeng Li, Yuanyuan Zhang, Jun Huang, Junjie Liu, Zimei Lin, Qinqin Yu, Aimin Wu, Bo Wang

“…And the essential amino acids for the human body, methionine and threonine, were highly accumulated in the high-quality cultivar. …”
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Evaluation of the Drug-Resistant Tuberculosis (DR-TB) management component under the National Tuberculosis Elimination Program (NTEP) in Kerala, India, 2021-22 by Raman Swathy Vaman, Madhanraj Kalyanasundaram, Malu Mohan, Narayana Pradeepa, Manoj V. Murhekar

“…The favorable treatment outcome was 80% Interviews revealed poor readiness and motivation from the private sector for screening, contextual barriers in human resource availability, transportation, and financial barriers to the beneficiary despite providing financial benefits. …”
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Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma by Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider

“…Here, we show that magnolol, a constituent of Magnolia officinalis, induced G1 arrest, apoptosis and cell death in BRAF‐ and NRAS‐mutant melanoma cells at low concentration, with no effect in BRAF‐ and NRAS wild‐type melanoma cells and human keratinocytes. This was confirmed in a 3D spheroid model. …”
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United Nations - African Union Cooperation In Conflict Prevention, Peacekeeping and Peacebuildin by L. I. Romadan, V. A. Shagalov

“…Through its agencies of ensuring peace and security the African Union is making significant contribution to strengthening stability and promotion of democracy and human rights in Africa. In the beginning of the article authors make a review of the level of security on the African continent and stress the sharpest conflict zones. …”
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Development and Implementation of an IoT-Based Early Flood Detection and Monitoring System Utilizing Time Series Forecasting for Real-Time Alerts in Resource-Constrained Environmen... by Nik Nor Muhammad Saifudin Nik Mohd Kamal, Ahmad Anwar Zainuddin, Abu Ubaidah Shamsudin, Muhamad Syariff Sapuan, Muhammad Hazim Amin Samsudin, Mohammad Adam Haikal Zulkfli

“…Traditional flood monitoring systems have severe limitations, including reliance on human data gathering, a lack of real-time capabilities, expensive prices, and slow response times, particularly in developing countries. …”
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Evaluation of antibiotic treatment initiation and duration practices in primary care. Cross-sectional study in two French multi-professional health centers. by Simon Ferme, Emmanuel Piednoir, Marianne Delestre, Elise Fiaux, Johann Masik, Renaud Verdon, Pascal Thibon

“…Antibiotic resistance poses a significant human and economic burden. In France, which ranks among the highest consumers of antibiotics in Europe, 93% of prescriptions are issued in primary care, primarily for respiratory tract infections. …”
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Enhancing Student Motivation and Competencies: Integrating E-Learning, Technological Literacy, and Cultural Alignment by Boumedyen Shannaq, Imran Saleem, Said AlRawahi, Saad Almhlawi, Said AlMaqbali

“…The research investigates the relationships between technological literacy (TL), cultural compatibility (CC), human face-to-face communication methods (HFtFCM), and student motivation and engagement (SMaE). …”
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Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…Nevertheless, studies of sociodemographic and medical-genetic characteristics of deaf people’s contemporary communities are important for predicting the prevalence of inherited forms of deafness, as well as for understanding the impact of social factors on the evolutionary processes occurring in human populations.…”
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Presence of Rickettsia Species in a Marginalized Area of Yucatan, Mexico by Gaspar Peniche-Lara, Bertha Jimenez-Delgadillo, Claudia Munoz-Zanzi, María Cárdenas-Marrufo, Carlos Pérez-Osorio, Juan Arias-León

“…We evaluated the vector diversity and the presence of Rickettsia species presence in the ectoparasite population that parasitizes domestic animals in a marginalized rural town of Yucatan, Mexico; we also evaluated the seroprevalence of rickettsial antibodies in the human population of this town in order to determine the prevalence of rickettsial infection. …”
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LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model by Ken S. Rosenthal, Sarah Stone, Gary Koski, Daniel H. Zimmerman

“…The prototype J-LEAPS T cell vaccine for HER-2/neu breast cancer (J-HER) consists of the murine HER-2/neu66–74 H-2d CD8 T cell epitope covalently attached through a triglycine linker to the J-immune cell binding ligand (ICBL) (human β2 microglobulin38–50 peptide). The J-ICBL was chosen for its potential to promote Th1/Tc1 responses. …”
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The phenomenon of laziness as a risk factor of high school students' fascination with gadgets by Ranno I. Sunnatova

“…In accordance with the understanding of the formation of subjectivity (the subject of productive development) in the ecopsychological model, the key condition is human activity. We suggested that the lack of activity or passivity of students in grades 8-11 may be a condition for the emergence of excessive enthusiasm for computer games and viewing social networks. …”
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Water scarcity: A global hindrance to sustainable development and agricultural production – A critical review of the impacts and adaptation strategies by Auindrila Biswas, Sourakanti Sarkar, Sumanta Das, Suman Dutta, Malini Roy Choudhury, Anmol Giri, Bimal Bera, Koushik Bag, Bishal Mukherjee, Koushik Banerjee, Debaditya Gupta, Debasish Paul

“…Even though water covers the vast majority of the earth’s surface, the availability of fresh water, which is necessary to maintain human activities, is limited, making it a scarce resource. …”
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TMFN: a text-based multimodal fusion network with multi-scale feature extraction and unsupervised contrastive learning for multimodal sentiment analysis by Junsong Fu, Youjia Fu, Huixia Xue, Zihao Xu

“…Abstract Multimodal sentiment analysis (MSA) is crucial in human-computer interaction. Current methods use simple sub-models for feature extraction, neglecting multi-scale features and the complexity of emotions. …”
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Challenges in academic performance among nursing students during flood disasters at a University in Dagupan City by Jordan Llego, Princess Erika Permison, Nicole Imbuido, Mikaella Concepcion, Lara Jane Caneja, Francine Joy Zaulda

“…Background: Disasters, both natural and human-made, universally affect communities and are recognized as major environmental and global challenges. …”
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