Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin by Yufeng Zhang, Huaxin Deng, Zhiqiang Yang, Zhe Chen, Sheng Zhang, Yufan Zhu, Min Yang, Houcheng Zhong, Fuling Zhou, Yuanlong Xie, Lin Cai

“…We use a single high-dose ionizing radiation (6Gy) to analyze the effect of radiotherapy on osteoblast function. Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) were cocultured with irradiated osteoblasts to examine their therapeutic effects and mechanisms on osteoblast injury. …”
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The utilisation of biliary organoids for biomedical applications by Zhongwen Lei, Yijun Yang, Yang Xiang, Yang Xiang

“…The main seed cells used to construct biliary tract organoids include primary human biliary tract epithelial cells as well as pluripotent stem cells. …”
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Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents by Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain

“…The synthesized compounds were assayed for in vitro human carbonic anhydrase (CA) inhibition against two isoforms II and IX. …”
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Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review by Raghavendra B. Narasimha, Singireddy Shreya, Vijay Anand Jayabal, Vikas Yadav, Prasana Kumar Rath, Bidyut Prava Mishra, Sudhakar Kancharla, Prachetha Kolli, Gowtham Mandadapu, Sudarshan Kumar, Ashok Kumar Mohanty, Manoj Kumar Jena

“…Although there are substantial studies revealing the treatment of human degenerative diseases using stem cells, this is yet to be explored in livestock animals. …”
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Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus by Yuan Liu, Liping Dai, Weihong Liu, Guixiu Shi, Jianying Zhang

“…Systemic lupus erythematosus (SLE) is one of the systemic autoimmune diseases characterized by the polyclonal autoantibody production. The human homologue of the mouse double minute 2 (MDM2) is well known as the negative regulator of p53. …”
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Cyberattack Monitoring Architectures for Resilient Operation of Connected and Automated Vehicles by Zulqarnain H. Khattak, Brian L. Smith, Michael D. Fontaine

“…The deployment of connected and automated vehicles (CAVs) may enhance operations and safety with little human feedback. Automation requires the use of communication and smart devices, thus introducing potential access points for adversaries. …”
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miR-224-5p Attenuates Allergic Responses in Mice with Allergic Rhinitis by Modulating the Th1/Th2 Response by Yuxiao Li, Ran An, Mingjin Wu, Jiayan He, Xiaoguang He

“…In this work, the mechanism by which miR-224-5p regulates AR in vivo and in vitro was examined. Methods. Human nasal epithelial cells (HNEpCs) were used to establish an AR cell model induced by Der P1, and C57BL/6 mice were used to establish an AR animal model induced by OVA (ovalbumin). …”
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Ethno-cultural particularity of English, French and Russian phrasiological units with components of names of domestic animals by E. N. Belaya

“…contains stereotyped representations of arrogant behavior of a person’s senseless activity who poses as the other person than he is in reality; of touch with Scottish realia and literature; 2) the figurative basis of French P.U. contains patterned and stereotyped representations of a person who works by the sweat of his brow, of the interaction of man and a horse, of a bad French, of a drunkard, a silly man who is fond of bombastic speech, of a cruel man; 3) the figurative basis of Russian P.U. contains stereotyped representations of a ridiculously dressed person, a pattern of human obstinacy; of touch with Russian peasant’s way of life. …”
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Exploring the Potential of Selenium-Containing Amine (Se-AMA) to Enhance Photosynthesis and Leaf Water Content: New Avenues for Carbonic Anhydrase Modulation in <i>Arabidopsis thal... by Sara Beltrami, Francesca Alderotti, Antonella Capperucci, Damiano Tanini, Cecilia Brunetti, Francesco Ferrini, Ermes Lo Piccolo, Antonella Gori

“…We hypothesize that the modulators of human CAs could affect plant physiology. Our research demonstrated that foliar treatments with a synthetic selenium-containing CA activator (Se-AMA) influenced the physiological performances of <i>Arabidopsis thaliana</i>. …”
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Ensemble automated approaches for producing high‐quality herbarium digital records by Robert P. Guralnick, Raphael LaFrance, Julie M. Allen, Michael W. Denslow

“…Discussion This work shows that an ensemble approach has particular value for creating high‐quality digital data records, even for complicated label content. While human validation is still needed to ensure the best possible quality, automated approaches can speed digitization of herbarium specimen labels and are likely to be broadly usable for all natural history collection types.…”
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Genetic Diversity of the Collection of Far Eastern <i>Actinidia</i> spp. Revealed by RAD Sequencing Technology by Natalia Slobodova, Maria Gladysheva-Azgari, Fedor Sharko, Kristina Petrova, Eugenia Boulygina, Svetlana Tsygankova, Irina Mitrofanova

“…More than ten species of the <i>Actinidia</i> Lindl. genus bear edible fruits rich in biologically active compounds, which are essential and beneficial for human health. The most popular cultivars today are the large-fruited <i>Actinidia</i> species, <i>A. deliciosa</i> and <i>A. chinensis</i>, commonly known as kiwi. …”
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Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling by Cheng-Hung Chuang, Yu-An Tai, Ting-Jing Wu, Ying-Jui Ho, Shu-Lan Yeh, Shu-Lan Yeh

“…The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. …”
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From deadly to life-saving effects: antimicrobial and antibiofilm effects of tarantula cubensis extract on bacterial and fungal pathogens by Elif AYDIN

“…Such natural poisons offer a promising and powerful solution to control microbial populations, combat pathogens, and protect human and animal health.…”
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Developing a GIS Model for Identifying Bear Corridors with Open-Source Data: The Romanian Context by Sanda Roșca, Alexandru Chira, Iuliu Vescan, Ștefan Bilașco, Ioan Fodorean, András-István Barta, Vasile Ceuca, Paul Sestraș

“…The fragmentation of the bears’ habitat is the main cause of conflict occurrences between bears and the human population, which have occurred increasingly often in recent years. …”
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Developing assistive robots for people with mild cognitive impairment and mild dementia: a qualitative study with older adults and experts in aged care by Elizabeth Broadbent, Craig Sutherland, Ngaire Kerse, Mikaela Law, Ho Seok Ahn, Bruce A MacDonald, Kathy Peri, Deborah L Johanson, Dina-Sara Vajsakovic

“…In study 2, participants were 10 experts in aged care.Results The themes that emerged included aspects of the robot’s interactions, potential benefits, the appearance, actions and humanness of the robot, ways to improve its functionality and technical issues. …”
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Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality by Noura Al-Dayan, Divya Venugopal, Sugapriya Dhanasekaran

“…The genetic architecture of the immune response genes in the Indian population, BCG vaccination, the predominantly young age group of people, and their traditional food habits might contribute to the lower rate of mortality. Human leukocyte antigens (HLA) play a vital role in triggering T cells, and natural killer (NK) cells can immediately react to eliminate infected cells. …”
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Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms by Najmeh Oliyaei, Saghar Zekri, Aida Iraji, Alireza Oliyaei, Romina Tanideh, Nadiar M. Mussin, Amin Tamadon, Nader Tanideh

“…Recent investigations in functional foods have demonstrated that diet and fortified foods play major therapeutic effects in human health, thus, the natural remedies have become an attractive approach. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Localized secretion of FlaB promotes phenotypic and functional remodeling of intratumoral macrophages that markedly inhibits tumor metastasis in mice bearing tumors of mouse and human origin. Both primary and metastatic tumors from bacteria-treated female mice are characterized by massive infiltration of anti-tumorigenic innate immune cells and activated tumor-specific effector/memory T cells; however, the percentage of immunosuppressive cells is low. …”
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Biological and Health-Promoting Potential of Fruits from Three Cold-Hardy Actinidia Species by Piotr Latocha, Ana Margarida Silva, Manuela M. Moreira, Cristina Delerue-Matos, Francisca Rodrigues

“…Fruits are essential components of the human diet, valued for their diverse bioactive compounds with potential health-promoting properties. …”
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Marital adjustment and quality of life among HIV discordant couples by Subhasis Bhadra, Nupur Tayal

“…Introduction Human immunodeficiency virus (HIV) is spreading at a very fast pace. …”
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