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27821
Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta
Published 2021-10-01“…Furthermore, SCE showed a potent cytotoxicity against human breast MCF-7 carcinoma cells (IC 50 27.73 µg/mL), whereas SCE treatment inhibited the activity of histone deacetylase (HDAC IC 50 37.70 µg/mL) and disturbed the pattern of cell cycle phases. …”
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27822
Fluids, faulting and earthquakes in the brittle crust: recent advances and new challenges
Published 2024-05-01“…Lastly, increase or decrease of $p_{f}$ in depth due to human activities such as hydrocarbon extraction, dam impoundment, gas storage or geothermal energy production result in many cases in the inception or enhancement of seismic activiy, adding clues in favor of a relationship between fluids and earthquakes.…”
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27823
PRMT1 Promotes the Self‐renewal of Leukemia Stem Cells by Regulating Protein Synthesis
Published 2025-02-01“…It is found that PRMT1 promotes the survival and serially plating abilities of human primary CML LSCs. Genetic deletion of Prmt1 significantly delays the leukemogenesis and impairs the self‐renewal of LSCs in BCR‐ABL–driven CML mice. …”
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27824
The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review
Published 2025-01-01“…Abstract Despite significant advances in HIV treatment, a definitive cure remains elusive. The first-in-human clinical trial of Excision BioTherapeutics’ CRISPR-based HIV cure, EBT-101, demonstrated safety but failed to prevent viral rebound. …”
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27825
Bioâdigestion and postâtreatment of effluents by bioâfermentation, an opportunity for energy uses and generation of organic fertilizers from bovine manure...
Published 2024-01-01“…Conclusion Both processes showed the viability as treatment of the bovine manure which brings renewable energy and effluents with nutritive loads to use it as a biofertilizer without risks to health and humanity. The project was located at the tropical zone into the Choco forest, at an average altitude of 1110 m above sea level and an average temperature annual of 21â22 °C.…”
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27826
Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values
Published 2025-02-01“…Lettuce (Lactuca sativa) is a widespread vegetable for human alimentation. Some systematic reviews showed parasitic contamination of lettuce in Brazil. …”
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27827
Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1)
Published 2016-06-01“…Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. …”
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27828
Predicted Mean Vote of Subway Car Environment Based on Machine Learning
Published 2023-03-01“…The variables include clothing temperature (CT), convective heat transfer coefficient between the surface of the human body and the environment (CHTC), black bulb temperature (BBT), and thermal resistance of clothes (TROC). …”
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27829
Spatio-temporal evolution and driving forces of urban gravity centers and ecological security risk gravity centers in China
Published 2025-01-01“…The ecological security risk gravity centers are situated closer to the geometric centers. (2) The migration trajectories can be broadly divided into two phases: from 2000 to 2010, the migration distance of the urban gravity centers in larger cities exceeded that in smaller cities, whereas from 2010 to 2020, the overall migration distance was more significant than that from 2000 to 2010. (3) The urban gravity centers and the ecological security risk gravity centers are influenced not only by natural factors such as elevation and terrain fluctuations but also by human factors based on population movement and development, as well as other factors, including infrastructure shifts driven by real-time policies.…”
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27830
ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1
Published 2021-08-01“…Currently, the mechanisms regulating ATG expression levels in human melanoma remains unknown. Using bioinformatic predictions of transcription factor (TF) binding motifs in accessible chromatin of primary melanocytes, we identified new TFs involved in the regulation of core ATGs. …”
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27831
Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis
Published 2025-02-01“…Praziquantel (PZQ) is the first line drug to treat human schistosomiasis. However, there is scarcity of pooled and summarized data on PZQ efficacy to policymakers. …”
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27832
A Global Lakes/Reservoirs Surface Extent Dataset (GLRSED): An Integration of Multi‐Source Data
Published 2025-01-01“…It can provide essential data for monitoring global lakes/reservoirs, support refined water resource management, and facilitate comprehensive studies on the impacts of human activities and climate change on these water bodies.…”
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27833
Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway
Published 2018-01-01“…This study investigated the effect of FMOD on human retinal pigment epithelial (RPE) cell, which plays an essential role in the progression of PVR, and the possible mechanisms. …”
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27834
Effects of Whole-Body 50-Hz Magnetic Field Exposure on Mouse Leydig Cells
Published 2004-01-01“…The cells were cultured for 48 h in the presence or absence of 1, 10, or 100 mIU/ml human chorionic gonadotropin (hCG). The luteinizing hormone (LH) analog hCG was used to check the testosterone (T) response of the sham-exposed controls and to evaluate the possible effect of the whole-body MF exposure on the steroidogenic capacity of Leydig cells in vitro. …”
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27835
The Spatio-temporal Evolution of NDVI in the Three Gorges Reservoir Area Driven by the Synergistic Effect of two Factors over the Past 21 Years
Published 2024-12-01“…[Objective] To clarify the spatio-temporal characteristics of vegetation evolution in the Three Gorges Reservoir Area, and to quantitatively analyze the relationships between vegetation and key determinants, including climate, terrain, and human activities. [Methods] Based on Normalized Difference Vegetation Index (NDVI) data, a suite of analytical techniques was employed, including Theil-Sen Median Trend Analysis, the Mann-Kendall Test for significance, Hurst Exponent Analysis, and Geographic Detector Modeling, to investigate the spatio-temporal patterns and driving forces of NDVI within the Three Gorges Reservoir Area from the year 2000 to 2020. …”
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27836
Genomic characterization of noroviruses from an outbreak associated with oysters
Published 2025-02-01“…ABSTRACT Human noroviruses are the leading cause of non-bacterial shellfish-associated gastroenteritis. …”
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27837
Cystic Echinococcosis/Hydatid Cyst Coinfection with HIV: A Report from Shiraz, Iran
Published 2021-01-01“…A few case reports describing echinococcosis with human immunodeficiency virus (HIV) infection have been reported in the world; however, it has not been reported in Iran, so far. …”
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27838
The Effect of the Functions of the Knowledge Management Maturity Triple Model on the Acquisition of Competitive Advantage Capabilities (Case Study: National Petrochemical Company)
Published 2022-08-01“…The dimensions of the model functions (organizational processes, human resources, technology, and knowledge content) also affected the company's competitive advantage capabilities. …”
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27839
Organizational Silence: Dimensions, Determinants, and Impact on Management - an Analytical Study
Published 2024-12-01“…The study examines how various human elements, such as age, gender, and educational qualifications, as well as organizational aspects, such as culture, knowledge management, and internal entrepreneurial settings, affect the occurrence of silence within businesses. …”
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27840
A geometrical optimisation of a coplanar micro-electrode structure for microfluidic flow cytometry
Published 2024-12-01“…This study focuses on optimising the geometry of a coplanar micro-electrode structure for detecting human lung adenocarcinoma cells (A549) within a fluid channel using impedance flow cytometry. …”
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