Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…We studied the properties of HCM cardiomyocytes (CMs) derived from patient-specific human induced pluripotent stem cells (hiPSCs) carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn mutation. …”
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Decoding the general role of tRNA queuosine modification in eukaryotes by Jorge Díaz-Rullo, Luis González-Moreno, Araceli Del Arco, José Eduardo González-Pastor

“…These bioinformatics results provide evidence to support for the first time in eukaryotes that the wide diversity of phenotypes associated with tRNA Q-modification previously described in various species would directly depend on the control of Q-genes translation, and would allow prediction of unknown Q-dependent processes, such as Akt activation and p53 expression, which we have tested in human cancer cells. Considering the relevance of the Q-related processes, our findings may support further exploration of the role of Q in cancer and other pathologies. …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy. …”
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Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…In this study, we examined whether scavenging of polymorphic Hp:Hb complexes differentially generated downstream anti-inflammatory signals in cultured human macrophages culminating in interleukin (IL)-10 secretion. …”
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Immunization‐related complex regional pain syndrome: A systematic review of case reports by William K. Copenhaver, Brandon J. Goodwin, Alexa Simonetti, Kunal P. Shah, Nicholas J. Averell, David F. Lo, Richard T. Jermyn

“…Studies included cases of CRPS development following tetanus, hepatitis B, hepatitis A, rubella, influenza, tetanus–diphtheria, human papillomavirus, and COVID‐19 vaccine administration. …”
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Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) by Stephanie Taniwan, Refi Ikhtiari, Stephanie Taniwan, Fiska Maya Wardhani

“…Skin, as the largest organ in the human and animal body, serves as the main protection against various external factors such as sharp objects, extreme temperatures, chemicals, or physical trauma. …”
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Fueling the Innovation Spark: How Employee Oriented HR Practices and Career Satisfaction Fosters Innovative Work Behavior? by Syed Mudasser Abbas, Zhiqiang Liu, Arshad Mahmood, Asma Mushtaq

“…This study aims to investigate how employee-oriented human resource (HR) practices (salary, job enrichment, job stability, training) can influence career satisfaction that subsequently affects employees' innovative behavior. …”
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IUPHAR Review: Alpha6-containing GABAA receptors – Novel targets for the treatment of schizophrenia by Lih-Chu Chiou, Werner Sieghart

“…So far, the beneficial actions of these modulators have been demonstrated in animal models of neuropsychiatric disorders, only. Future human studies have to investigate the safety and possible side effects of these modulators and to clarify, to which extent individual symptoms of schizophrenia can be reduced by these drugs in patients during acute and chronic dosing.…”
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On the Design and Development of Planar Monopole Antenna for Bone Crack/Void Detection by Ananda Venkatesan Boologam, Kalimuthu Krishnan, Sandeep Kumar Palaniswamy, Sachin Kumar, Shreya Bhowmik, Nivesh Sharma, Deepesh Vaish, Sourish Chatterjee

“…This method can detect bone fractures in a noninvasive manner. The human arm model is constructed, and the effect of bone cracks of different lengths on the resonating frequency is investigated. …”
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Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…In addition to undertaking established mEV assays of structure and function on our preparations, we introduce a novel, efficient, high throughput assay of mEV bioactivity based on Electric Cell Substrate Impedance Sensing (ECIS) in Human dermal fibroblast monolayers. By adding appropriate excipients, such as trehalose and tryptophan, we describe a protective formulation that preserves mEV bioactivity during long-term, room temperature storage. …”
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Mechanism of Action of Lacticaseibacillus paracasei HNU502 and Fecal Microbiota Transplantation in Alleviating Antibiotic Side Effects by CHEN Lin, LI Ao, LI Jiahe, ZHANG Zeng, ZHANG Jiachao

“…This study contributes to a better understanding of the link between human health and gut microbiota, and provides new therapeutic options for mitigating antibiotic side effects, which is of great significance for improving patients’ health status and quality of life.…”
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Spatial-temporal differentiation and influencing factors of ecosystem health in Three-River-Source national Park by Yanqin Wang, Huaju Xue, Aiqing Li, Xiaofan Ma, Ailing Sun, Jinhe Zhang

“…It also showed significant “high-high” and “low-low” clustering effects in the eastern and northwestern regions. (3) Among all the indicators assessed, ecosystem vigor was the indicator that contributed the most to the growth of the ecosystem health index. (4) Variations in ecosystem health of TNP were mainly shaped by land use intensity and precipitation, and interactions between natural environmental factors and human activity factors enhanced the explanation of these changes. …”
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Awifauna wodno-błotna środkowej Wisły w okresie lęgowym: wpływ działalności człowieka na rozmieszczenie, liczebność i bogactwo gatunkowe by Dariusz Bukaciński, Monika Bukacińska, Arkadiusz Buczyński

“…It will allow us to estimate soberly how very the intensity of human utilization of the river affects the distribution of avifauna of the Vistula, determining the richness and abundance of valuable and/or endangered species breeding in a given area.…”
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Urinary glucose detection with spiral shape hollow core photonic crystal fiber: Towards improved diabetes management by Md. Safiul Islam, A.H.M. Iftekharul Ferdous, Md. Jakir Hossen, Abdullah Al Mamun, Khalid Sifulla Noor, Diponkar Kundu, Md. Galib Hasan

“…Insufficient insulin leads to an inability to transform glucose into energy, resulting in increased amounts of glucose in human body. Acute diabetes treatment and follow-up rely on urine glucose detection since it provides a non-invasive, reasonably priced means to assess glucose levels and regulate the progression of the disease. …”
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Geospatial perspective for monitoring SDG 6.6.1 based on spatial and temporal analysis of lake water storage variations in Dongting Lake, China by Huanhua Peng, Zihan Tang, Zhiming Chen, Yating Wu, Yuan Yuan, Qian Shi, Lelin Li, Hao Chen

“…This study not only provide a geospatial perspective for monitoring water storage for SDG 6.6.1 under the climate oscillations and human impacts in a large floodplain lake but also provide an important scientific basis for improving the optimal allocation of water resources of the Dongting Lake area. …”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Mutations in RECQL4 have been associated with various human diseases, including Rothmund–Thomson syndrome. …”
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Brake Drum Temperature Rise and Its Influence on Truck Driving Safety in Tunnel Groups Section by Yunyong He, Enhuai He, Le Zhang, Jianping Gao, Changfeng Yang, Lu Sun, Haotian Yang, Zhen Gong, Ziqiang Liu

“…The study collects data on brake drum temperature and braking duration from an experimental vehicle under the coupling action of human-vehicle-road-environment. Through comparative analysis, theoretical derivation, and model construction, conclusions are drawn. …”
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RETRACTED: Palmitic Acid Impedes Extravillous Trophoblast Activity by Increasing MRP1 Expression and Function by Yunali Ashar, Qiuxu Teng, John N. D. Wurpel, Zhe-Sheng Chen, Sandra E. Reznik

“…HTR-8/SVneo and Swan-71 cells, first trimester human EVTs, were grown in the absence or presence of 0.5 mM and 0.7 mM palmitic acid, respectively, for 72 h. …”
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PD‐1+CD8+ T Cell‐Mediated Hepatocyte Pyroptosis Promotes Progression of Murine Autoimmune Liver Disease by Jie Long, Si‐Yu Yang, Zhen‐Hua Bian, Hao‐Xian Zhu, Min Ma, Xiao‐Qing Wang, Liang Li, Weici Zhang, Ying Han, M. Eric Gershwin, Zhe‐Xiong Lian, Zhi‐Bin Zhao

“…A spontaneous severe murine model of autoimmune liver disease has been previously established in dnTGFβRII Aire−/− mice, exhibiting disease phenotypes that resemble both human primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). …”
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Systematic Review and Meta-Analysis of the Evaluation of the Efficacy of Manipulation and Cervical Traction in the Treatment of Radical Cervical Spondylosis by Jianquan Chen, Rongbin Chen, Yong Li, Maoshui Chen, Zhouming Lv, Haobin Zeng, Qiang Lian

“…Once suffering from this disease, it is often difficult to cure and recurring, with complex clinical symptoms, causing a serious impact on human health. Objective. To evaluate the efficacy of manipulation and cervical traction in the treatment of radical cervical spondylosis. …”
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