MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy performed on neural cells at various developmental stages, from human embryonic stem cells to neurons.ResultsThe MetaboLINK analysis of longitudinal metabolomics data has revealed distinct pathways related to amino acids, lipids, and energy metabolism, uniquely associated with specific cell progenies. …”
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Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts by Stefania Niada, Chiara Giannasi, Alice Gualerzi, Giuseppe Banfi, Anna Teresa Brini

“…The proosteogenic effect of DF secretome was validated in vitro on human primary osteoblasts, providing a proof of concept of its osteoinductive potential. …”
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RETRACTED ARTICLE: Multiclass skin lesion classification using deep learning networks optimal information fusion by Muhammad Attique Khan, Ameer Hamza, Mohammad Shabaz, Seifeine Kadry, Saddaf Rubab, Muhammad Abdullah Bilal, Muhammad Naeem Akbar, Suresh Manic Kesavan

“…The most prevalent causes of skin lesions are UV radiation, which can damage human skin, and moles. If skin cancer is discovered early, it may be adequately treated. …”
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Engagement in a web-based intervention for individuals who committed sexual offenses against children: observational study by Sonja Schröder, Safiye Tozdan, Peer Briken, Jürgen L. Müller, Peter Fromberger

“…Using data from an intermediate analysis of the randomized placebo-controlled clinical trial to evaluate the effectiveness of @myTabu, the current study investigated engagement with a web-based intervention for 113 individuals convicted of child sexual abuse and/or for child sexual exploitation material. @myTabu is a human-supported, web-based intervention for individuals who have been convicted for sexual abuse of children or the use of child sexual exploitation material with the goal of reducing the risk factors for recidivism and actual recidivism. …”
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Intelligent Prediction of Flood Disaster Risk Levels Based on Knowledge Graph and Graph Neural Networks by Peisheng Yang, Xiaohua Xu, Meilan Shao, Yewei Liu

“…Flash flood disasters pose a significant threat to human life and property, making accurate prediction of risk levels crucial for disaster prevention and mitigation. …”
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Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking by Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar

“…Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. …”
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Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice by Ziyi Xiong, Qiling Kong, Juan Hua, Qi Chen, Dandan Wang

“…They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. …”
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Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock by David A. C. Messerer, Stephanie Denk, Karl J. Föhr, Rebecca Halbgebauer, Christian K. Braun, Felix Hönes, Julia Harant, Michael Fauler, Manfred Frick, Benedikt L. Nußbaum, Peter Radermacher, Sebastian Hafner, Markus S. Huber-Lang

“…Electrophysiological changes in cellular and mitochondrial membrane potential and intracellular pH of PMN from human healthy volunteers were determined by flow cytometry after exposure to C5a. …”
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Assessing the ecological consequences of crude oil spills on bird communities in an Afrotropical landscape by Iniunam Aniefiok Iniunam, Talatu Tende, Adams Adamanyiwa Chaskda

“…Our study highlights the cascading effects of oil spills on ecosystem services provided by birds, which are vital for human well-being. This research fills a critical gap in understanding the ecological consequences of oil spills on avian communities within the oil-rich Niger Delta area in tropical Africa. …”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Abstract Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. …”
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Comparison of Adaptation and Microleakage of CAD/CAM Restorations to Inlay Cavities Prepared by Using Different Finishing Methods by Ayben Şentürk, Mehmet Ali Kılıçarslan, Merve Çakırbay Tanış, Mert Ocak, İbrahim Berk Bellaz

“… Purpose: To compare the adaptation and microleakage of CAD/CAM inlay restorations using conventional or ultrasonic finishing equipment and their combinations.Materials & Methods: Inlay cavities were prepared on 66 extracted human lower first molar teeth using one of the following finishing methods: Group I: straight fissure diamond bur; Group II: fissure diamond bur and ultrasonic tip; Group III: 6º tapered conical diamond bur; Group IV: 6º tapered conical diamond bur and ultrasonic tip. …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…Here, we identified the role of cysteine 133 in RKIP structural dynamics using recombinant human RKIP (rhRKIP) proteins purified from <i>Escherichia coli</i> BL21(DE3) cells. …”
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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years by Frank Tacke, Martina E. Spehlmann, Mihael Vucur, Fabian Benz, Mark Luedde, David Vargas Cardenas, Sanchari Roy, Sven Loosen, Hans-Joerg Hippe, Norbert Frey, Christian Trautwein, Alexander Koch, Christoph Roderburg, Tom Luedde

“…Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.…”
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Identification and optimization of urban wetland ecological networks in highly urbanized areas: A case study of Haidian District, Beijing by Wang Zecheng, Zhao Xinsheng, Cui Lijuan, Lei Yinru, Guo Ziliang, Wang Jinzhi, Li Jing, Zhai Xiajie, Wang Rumiao, Li Wei

“…With the rapid development of urbanization, urban wetlands have been severely damaged by human activities and natural factors, leading to problems such as reduced area and decreased connectivity between wetlands. …”
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Protocol for a qualitative study exploring haemodialysis dependent patients’ arteriovenous fistula experience, values and concerns in Sydney, Australia by Vasi Naganathan, Sarah Joy Aitken, Bethany Miriam Stavert, Susan Monaro, Lisa Tienstra

“…Findings from this study will give a nuanced insight into the experiences of patients on haemodialysis with respect to their AVF.Ethics and dissemination Ethical approval for this study was provided by the Sydney Local Health District Human Research Ethics Committee (REGIS identifier: 2021/ETH00362, CH reference number: CH62/6/2021-033). …”
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Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State by Marie Koren-Gluzer, Mira Rosenblat, Tony Hayek

“…The direct effect of PON2 was shown by transfecting human PON2 (hPON2) into PON2KO MPM. PON2 transfection attenuated the macrophages’ response to M1 activation and enhanced M2 response. …”
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Suppressive Activity of a Macrolide Antibiotic, Roxithromycin, on Pro-Inflammatory Cytokine Production in Vitro and in Vivo by H. Suzaki, K. Asano, S. Ohki, K. Kanai, T. Mizutani, T. Hisamitsu

“…In the first experiments, we examined the effect of RXM on in vitro cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes. The monocytes were cultured in the presence of various doses of the agent. …”
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Abortion Laws in Indonesia and Islam: A Clash of Morality, Religion, and Rights by Salsabila Triandani, Windiahsari Windiahsari, Ali Masyhar, Aprila Niravita

“…The paper also addresses ongoing debates over potential legal reforms, considering global human rights perspectives and the influence of Islamic jurisprudence in shaping reproductive health policies. …”
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Uncertainties of the rainfall regime in a tropical semi-arid region: the case of the State of Ceará by Eunice Maia de Andrade, Maria Gina Torres Sena, Antonio Givanilson Rodrigues da Silva, Francisco Jairo Soares Pereira, Fernando Bezerra Lopes

“…The rural population of a tropical semi-arid region such as the northeast of Brazil is directly dependent on rainfall for agricultural production, pasture for livestock, and the storage of drinking water for human consumption. The region is characterised by the frequent occurrence of dry years and consecutive dry days (CDD) during the rainy season, demonstrating the vulnerability of rainfed agriculture. …”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…The liposomal membrane contains 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), two phospholipids sensitive to secreted phospholipase A2 in human colorectal tumors. In an orthotopic colorectal murine tumor model, phospholipase-induced membrane permeabilization triggers the liberation of DMSN from liposomes for enhanced tumor penetration, conferring an enhanced suppression for the primary tumor. …”
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