Morbidity of SARS-CoV-2 in the evolution to endemicity and in comparison with influenza by Istvan Bartha, Cyrus Maher, Victor Lavrenko, Yi-Pei Chen, Qiqing Tao, Julia di Iulio, Keith Boundy, Elizabeth Kinter, Wendy Yeh, Davide Corti, Amalio Telenti

“…Abstract Background There are three possible SARS-CoV-2 post-pandemic scenarios: (i) ongoing severity, (ii) influenza-like severity, and (iii) a transition to an endemic disease with lesser morbidity similar to that of other human coronaviruses. Methods To assess a possible evolution of the pandemic under the three scenarios, we use data from the US National Covid Cohort Collaborative, CDC COVID-NET, and CDC Fluview and from the WastewaterSCAN Dashboard. …”
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Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus by Bita Moudi, Saeedeh Salimi, Farzaneh Farajian Mashhadi, Mahnaz Sandoughi, Zahra Zakeri

“…FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. Materials and Methods. …”
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Elevation of natural vulnerability in the karst aquifers (case study: karst aquifers of Sheshpier and Borgan, Fars province) by Mehdi kashefi, mojgan entezari, maryam Jafari Aghdam

“…Natural vulnerability is based on the geomorphologic features of surface karst, type and level of aquifer recharge and hydrodynamic aquifer karstic aquifer in Fars province is the most important source of water supply for the supplement of drinking water of communities in the province, which are prone to pollution due to the natural conditions of the region and human activities. karstic aquifer of Shispir and Borghan plays a vital role in supplying drinking and agricultural water around them. …”
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Elevated Concentration of Defensins in Hepatitis C Virus-Infected Patients by Ehab H. Mattar, Hussein A. Almehdar, Abdullah A. AlJaddawi, Isam ElDin M. Abu Zeid, Elrashdy M. Redwan

“…Hepatitis C virus (HCV) is the major etiological agent of human non-A and non-B hepatitis, affecting around 180 million people worldwide. …”
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Influence of irrigation with oxygen plasma treated metal contaminated water on plant growth by Sayma Khanom, Nobuya Hayashi

“…Exposure to large amounts of zinc, even for a short duration, can seriously impact human health. In this experiment, three different DBD (dielectric barrier discharge) O2 plasma treated zinc contaminated water and a control (tap water) were used, with Arabidopsis thaliana as the model plant. …”
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Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus by Jiaqi Bao, Dawei Cui, Xiaochen Wang, Qianda Zou, Dejian Zhao, Shufa Zheng, Fei Yu, Li Huang, Yuejiao Dong, Xianzhi Yang, Guoliang Xie, Weizhen Chen, Yu Chen

“…In this study, we found that the frequencies of Th17 and Tc17 cells among human peripheral blood mononuclear cells (PBMCs) as well as IL-17A protein and mRNA levels were markedly decreased in patients with acute H7N9 virus infection. …”
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Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

“…Abstract Returning to the moon and traveling to Mars represent the main targets of human space exploration missions within the upcoming decades. …”
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Effect of aeration rate on elimination of coliforms during composting of vegetableâfruit wastes by E. IÅıl Arslan Topal, Ayhan Ãnlü, Murat Topal

“…Composts originated from extrements, sewage sludges and plant wastes those contact with manures may have potential health hazard to human. Therefore, the detection of coliforms both during composting and in the obtained composts is used to investigate the presence of pathogens for determination of the potential health risk. …”
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Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction by Line Lisbeth Olesen, Thomas Vauvert F. Hviid

“…The immune system is activated in LVSD, and the immunomodulatory molecule human leukocyte antigen-G (HLA-G) may be involved. …”
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Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib by Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski, Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

“…Serum cytokine levels were assayed with Bio-Rad Bio-Plex Pro Human Cytokine 27-Plex Assay on the MAGPIX Multiplex Reader and the Bio-Plex® 200 System (Bio-Rad). …”
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Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP by Tongzhou Liang, Jincheng Qiu, Shaoguang Li, Zhihuai Deng, Xianjian Qiu, Wenjun Hu, Pengfei Li, Taiqiu Chen, Zhancheng Liang, Hang Zhou, Bo Gao, Dongsheng Huang, Anjing Liang, Wenjie Gao

“…To further investigate the mechanism that SR3335 regulates the pathogenesis of IDD in vitro, tumor necrosis factor alpha (TNF-α) stimulation was used in human NP cells to mimic the hostile environment that leads to degeneration. …”
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Investigating spatially varying relationships between the distribution of rural settlements and related influences by Chenzhao Yuan, Guanglong Dong, Zheng Liu

“…The distribution of rural settlements is a complex outcome of human adaptation to natural conditions and socioeconomic development throughout history. …”
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CD14loCD301b+ macrophages gathering as a proangiogenic marker in adipose tissues by Yibing Lv, Yidan Zheng, Shanshan Su, Junyi Xiao, Jie Yang, Lingyun Xiong, Yanyan Guo, Xiaoqi Zhou, Nengqiang Guo, Ping Lei

“…And the loss of CD14 alleviated high-fat diet–induced obesity in mice. In human subjects, CD14 level was tested to be positively correlated with overweight and obesity. …”
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Contemporary issues in ensuring biological safety during disposal of biological wastes of animal origin by incineration in the Russian Federation by A. V. Belchikhina, M. A. Shibayev, A. M. Selyanin, A. K. Karaulov

“…Animal management and breeding as well production, transportation, preparation, and processing of animal products and raw material result in generation of a considerable amount of biological wastes being a source of biological contamination of the environment and a clear threat to human and animal health. The animal biowaste incineration units are high threat facilities and require constant surveillance and control. …”
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Marginal and Internal Adaptation Evaluation of Dental Composites Using Micro-CT by Adrian Tudor Stan, Laura Cîrligeriu, Laura Idorași, Meda Lavinia Negruțiu, Cosmin Sinescu, Daniela Maria Pop, Tareq Hajaj, Şerban Talpoș, Mihai Romînu

“…Forty previously extracted human molars, kept in 10% formalin to preserve the bonding capabilities of the tooth structures, were divided into four groups based on the composite system used and different light-curing times. …”
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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…Here, we demonstrate the following: both human breast cancer and murine mammary carcinoma cells support viral replication and IL-12 expression from M002; M002 replicates in and destroys breast cancer cells from a variety of histological subtypes, including “triple-negative” and HER2 overexpressing; M002 improves survival in an immunocompetent model more effectively than does a non-cytokine control virus. …”
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Evaluation of Airport Buildings Against Terrorist Attacks in the Context of Architecture and Planning Criteria: Five Case Study by SARICIOĞLU Pelin, YILDIZ Aslı, SOYLUK Asena

“…One of the most common types of structures where these attacks are carried out is airport structures due to their international visibility and intense human circulation. Necessary precautions should be taken against possible terrorist attacks both in the planning and utilization process of airports. …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…In this review, we will report the most recent studies that have leveraged PAL to disclose the biological targets and mechanism of action of phenotypically active compounds targeting kinetoplastid diseases (i.e., human African trypanosomiasis, leishmaniasis, and Chagas disease) and malaria. …”
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A robust multi-objective multi-priodic planning approach to the problem of locating the allocation of organ transplant centers under conditions of uncertainty by Elham Nejati, Mahdi Yousefi Nejad Attari, Asgar Hajibadali

“…Purpose: One of the most vital subcategories of the health care system is organ transplantation, and since organ transplant centers deal directly with surgical operations and, as a result, human lives, the importance of this issue has received more attention. …”
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Inhibitory Effect of (2S)-Pinocembrin From Goniothalamus macrophyllus on the Prostaglandin E2 Production in Macrophage Cell Lines by Hilwan Yuda Teruna, Kamal Rullah, Rudi Hendra, Rahayu Utami, Deri Islami, Siti Munirah Mohd Faudzi, Mohd Fadhlizil Fasihi Mohd Aluwi, Kok Wai Lam

“…To evaluate deeper into the anti-inflammatory potential of the specific enantiomer of natural PCB, we conducted the first investigation into the efficacy of the pure enantiomer (2S)-PCB in modulating inflammatory mediators induced by lipopolysaccharide (LPS) in both murine RAW 264.7 and human U937 macrophage cell lines. This particular compound was isolated from Goniothalamus macrophyllus (Annonaceae), a native plant of Indonesia. …”
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