Administration of Iodine-125 Seeds Promotes Apoptosis in Cholangiocarcinoma through the PI3K/Akt Pathway by Junqing Lin, Leye Yan, Xiaolong Wang, Zhengzhong Wu, Kun Ke, Xin Lin, Ning Huang, Weizhu Yang

“…We aimed to examine the effects of 125I seeds on the gene expression of Bcl-2, Bax, and PI3K/Akt pathway components in cholangiocarcinoma cells. Methods. In vitro, human cholangiocarcinoma RBE cells were treated with 125I seeds (0.39 mCi or 0.85 mCi) for 72 h, 120 h, and 168 h. …”
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Complex and severe infection in a 67-year-old liver transplant recipient due to Cunninghamella elegans, Bordetella bronchiseptica, and Pneumocystis jirovecii by Muyun Wei, Kangyi Gu, Juanxiu Qin, Xinhua Lu, Junqi Feng, Shaowei Mao, Min Li, Zhilan Li, Changsheng Wang

“…B. bronchiseptica, P. jirovecii, Aspergillus fumigatus, and human alphaherpesvirus 1 (HSV1) were detected by clinical metagenomic next-generation sequencing (mNGS) of his bronchoalveolar lavage fluid (BLAF). …”
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A High-Quality Phased Genome Assembly of Stinging Nettle (<i>Urtica dioica</i> ssp. <i>dioica</i>) by Kaede Hirabayashi, Christopher R. Dumigan, Matúš Kučka, Diana M. Percy, Gea Guerriero, Quentin Cronk, Michael K. Deyholos, Marco Todesco

“…Stinging nettles (<i>Urtica dioica</i>) have a long history of association with human civilization, having been used as a source of textile fibers, food and medicine. …”
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Phenolic Compounds from Apples: Reviewing their Occurrence, Absorption, Bioavailability, Processing, and Antioxidant Activity – a Review by Małgorzata Starowicz, Bohdan Achrem–Achremowicz, Mariusz K. Piskuła, Henryk Zieliński

“…This review summarises the research on phenolic compounds in apples in relation to their geographical origin, cultivars, technological processes, and human health effects due to their antioxidant activity and bioavailability. …”
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On-grid Photovoltaic Power System for Governmental Office Electrification by Ali Nasser Hussain, zuhair sameen shuker, Majid Khudair Abbas Al-Tamimi, Mimouna Abid

“…The potential solar energy has a capacity to meet all energy requirements for human survival on planet earth. Some applications such as a thermoelectric generator, electric power generation with the assistance of solar panels and water applications are required to reduce the demand for electricity generated by conventional power plants. …”
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C-BERT: A Mongolian reverse dictionary based on fused lexical semantic clustering and BERT by Amuguleng Wang, Yilagui Qi, Dahu Baiyila

“…Compared to the seven baseline models, C-BERT demonstrates superior performance, particularly when evaluated on datasets with human-generated descriptions, where its synonym accuracy@10/100 reaches 16.5% and 71%, respectively. …”
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High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs... by Zifang Peng, Shijiao Hou, Qingyun He, Fangcheng Su, Lishun Ren, Congcong Pei, Dan Yin, Yanhao Zhang, Yanjie Huang, Shusheng Zhang, Zongwei Cai

“…Current study builds the relationship between pollution status of such novel pollutants and human activities, and possibly guides people in central China to take precautions to protect themselves from environmental toxicants at special daily time.…”
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Multicellular Tumor Spheroids as an in Vivo–Like Tumor Model for Three-Dimensional Imaging of Chemotherapeutic and Nano Material Cellular Penetration by Hui-li Ma, Qiao Jiang, Siyuan Han, Yan Wu, Jin Cui Tomshine, Dongliang Wang, Yaling Gan, Guozhang Zou, Xing-Jie Liang

“…Our data revealed that 3D cultured HeLa cells acquired several clinically relevant morphologic and cellular characteristics (such as resistance to chemotherapeutics) often found in human solid tumors. These characteristic, however, could not be captured using conventional two-dimensional cell culture techniques. …”
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Les comités de santé et de sécurité dans les petites entreprises multiethniques de Montréal by Gabrielle Legendre, Sylvie Gravel, Jacques Rhéaume

“…The results indicate that the factors that fostered the establishment and proper functioning of OHS were : the size of the business, the activity sector, the presence of a union, the presence of arguments favourable to OHS, the type of business, the presence of an OHS manager who was in a human resource or OHS position and who had university training in one of these two fields or in administration. …”
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Exploring brain perfusion in dogs with meningoencephalitis of unknown origin: A promising role for arterial spin labeling imaging by Léa Arti, Kirsten Gnirs, Stella Papageorgiou, Yannick Ruel, Albert Agoulon, Nathalie Boddaert, Hugues Gaillot

“…Preferential lesion localization in ON and brainstem resembled findings in the central nervous system of human patients with inflammatory demyelinating diseases. …”
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Protein Ubiquitylation in Pancreatic Cancer by Thomas Bonacci, Julie Roignot, Philippe Soubeyran

“…Whereas it has been known for more than 3 decades now, ubiquitylation is a post-translational modification of protein that only recently emerged as a major regulator of many biological functions, dependent and independent on the proteasome, whose failure is involved in many human diseases, including cancer. Indeed, despite its role in promoting protein degradation through the proteasome, ubiquitylation is now known to regulate diverse cellular processes, such as membrane protein endocytosis and intracellular trafficking, assembly of protein complexes, gene transcription, and activation or inactivation of enzymes. …”
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Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…The inverse correlation between NK activity and metastasis incidence supports a critical role for NK cells in human metastatic surveillance. However, autologous NK cell therapy has shown limited benefit in treating patients with metastatic solid tumors. …”
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Upregulation of HSP90α in the lungs and circulation in sarcoidosis by Takuma Isshiki, Takuma Isshiki, Takuma Isshiki, Motoko Sunakawa, Megan Vierhout, Megan Vierhout, Anmar Ayoub, Anmar Ayoub, Pareesa Ali, Pareesa Ali, Safaa Naiel, Safaa Naiel, Shion Miyoshi, Asghar Naqvi, Nathan Hambly, Kazuma Kishi, Kjetil Ask, Kjetil Ask, Martin R. J. Kolb

“…Extracellular HSP90α released from macrophages was examined in human primary cells and an immortalized cell line.ResultsMacrophages and granulomas in sarcoidosis-affected lungs showed high HSP90α expression. …”
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Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects by Renxin Zhang, Zhiyuan Chen, Shuhan Li, Haohao Lv, Jinjun Li, Naixue Yang, Shaoxing Dai

“…This study evaluated the druggability of the entire human proteome using Fpocket. We identified 15,043 druggable pockets in 20,255 predicted protein structures, significantly expanding the estimated druggable proteome from 3000 to over 11,000 proteins. …”
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How do improved lentil varieties affect farmers’ livelihood status in central Bangladesh? by Monira Sultana, Jannatul Ferdous Shetu, Fatema Sarker, Sharif Ahammad, Md. Hayder Khan Sujan

“…Major changes were observed in the human, natural, and physical capital of the lentil growers. …”
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Prevalence and Knowledge about Genital and other Warts among Students in Sulaimani Polytechnic University: A cross-sectional study by Burhan Karadaghy, Niaz Mustafa Kamal, Nasih Othman

“…Genital warts and other warts are an epidermal manifestation attributed to the epidermotropic human papillomavirus (HPV) some of which have been linked directly to an increased neoplastic risk in men and women. …”
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The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials by Hossein Hatami, Elnaz Ataei, Mohammadjavad Nasiri, Hamed Ghorani

“…Three studies investigated the efficacy of CAR T-cell therapy against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus (CMV). …”
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Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR by Francisco J. Rios, Marianna M. Koga, Mateus Pecenin, Matheus Ferracini, Magnus Gidlund, S. Jancar

“…It was found that the presence of oxLDL during macrophage differentiation induced high mRNA levels to IL-10, mannose receptor, PPARγ and arginase-1 and low levels of IL-12 and iNOS. When human THP-1 macrophages were pre-treated with oxLDL then stimulated with LPS, the production of IL-10 and TGF-β significantly increased, whereas that of IL-6 and IL-8 decreased. …”
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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy by Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu

“…Furthermore, itraconazole suppressed Hedgehog signaling and counteracted the activation of the Hedgehog agonist recombinant human Sonic Hedgehog (rhShh). In vivo, itraconazole significantly reduced tumor growth in A375 and A2058 xenograft models.ConclusionItraconazole induces autophagy-mediated apoptosis in melanoma cells by inhibiting Hedgehog signaling, underscoring its potential as a therapeutic option for melanoma treatment.…”
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A Multispectral Automated Transfer Technique (MATT) for Machine-Driven Image Labeling Utilizing the Segment Anything Model (SAM) by James E. Gallagher, Aryav Gogia, Edward J. Oughton

“…This research greatly contributes to the study of multispectral object detection by providing a novel and open-source method to rapidly segment, label, and train multispectral object detection models with minimal human interaction. Future research needs to focus on applying these methods to 1) space-based multispectral; and 2) drone-based hyperspectral imagery.…”
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