Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy? by Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck

“…Talimogene laherparepvec is an oncolytic herpes simplex virus type 1 (oHSV), approved for the treatment of recurrent melanoma, and the virus encodes the human cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF). …”
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Gaps in U.S. livestock data are a barrier to effective environmental and disease management by Rebecca Logsdon Muenich, Sanskriti Aryal, Amanda J Ashworth, Michelle L Bell, Melanie R Boudreau, Stephanie A Cunningham, K Colton Flynn, Kerry A Hamilton, Ting Liu, Michael L Mashtare, Natalie G Nelson, Barira Rashid, Arghajeet Saha, Danica Schaffer-Smith, Callie Showalter, Aureliane Tchamdja, Jada Thompson

“…Livestock are a critical part of our food systems, yet their abundance globally has been cited as a driver of many environmental and human health concerns. Issues such as soil, water, and air pollution, greenhouse gas emissions, aquifer depletion, antimicrobial resistance genes, and zoonotic disease outbreaks have all been linked to livestock operations. …”
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Cómo crear ediciones digitales académicas entre La Habana y Berlín. El caso de Proyecto Humboldt Digital (ProHD) by Antonio Rojas-Castro, Grisel Terrón Quintero, Alaina Solernou Ferrer, Tobias Kraft

“…After outlining the origins, we present the workflow developed between the Oficina del Historiador de la Ciudad de La Habana and the Berlin-Brandenburg Academy of Sciences and Humanities to digitize, describe, publish, edit and preserve in digital format a collection of previously selected texts. …”
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ANALYSIS OF INFRASTRUCTURE DEVELOPMENT FOR SUSTAINABLE HOUSING IN LAGOS MEGACITY, NIGERIA by Adetokunbo O. Ilesanmi

“…The study stressed the importance of infrastructure to human and economic development, with the objective of determining the sustainability of urban housing development in the context of neighbourhood infrastructure provision in the study area. …”
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Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases by Ana I. Rojo, Brigitta Buttari, Susana Cadenas, Ana Rita Carlos, Antonio Cuadrado, Ana Sofia Falcão, Manuela G. López, Milen I. Georgiev, Anna Grochot-Przeczek, Sentiljana Gumeni, José Jimenez-Villegas, Jarosław Olav Horbanczuk, Ozlen Konu, Isabel Lastres-Becker, Anna-Liisa Levonen, Viktorija Maksimova, Charalambos Michaeloudes, Liliya V. Mihaylova, Michel Edwar Mickael, Irina Milisav, Biljana Miova, Patricia Rada, Marlene Santos, Miguel C. Seabra, Dubravka Svob Strac, Sandra Tenreiro, Ioannis P. Trougakos, Albena T. Dinkova-Kostova

“…NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE). …”
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High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor by Jie Hu, Weihao Lin, Liyang Shao, Chenlong Xue, Fang Zhao, Dongrui Xiao, Yang Ran, Yue Meng, Panpan He, Zhiguang Yu, Jinna Chen, Perry Ping Shum

“…Experimental results obtained from human serum samples are consistent with clinical data, highlighting the strong clinical application potential of the proposed sensing system and analysis method.…”
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Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America by Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti

“…Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL. Biopsies (n=20) from human cutaneous nonulcerative lesions were collected and processed by usual histological techniques. …”
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Towards a Bipolar World. Book Review of ‘The Second World War and the Transformation of International Relations: From Multipolarity to a Bipolar World’ edited by L.S. Belousov and... by V. I. Batyuk

“…In 2020 the whole world commemorated the 75th anniversary of the end of World War II — the most horrifi c war in the human history. However, the celebration of the victory over fascism was overshadowed by the growing tension among the leading actors of contemporary international relations. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Abstract Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct‐acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. …”
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IncF Plasmids Are Commonly Carried by Antibiotic Resistant Escherichia coli Isolated from Drinking Water Sources in Northern Tanzania by Beatus Lyimo, Joram Buza, Murugan Subbiah, Sylivester Temba, Honest Kipasika, Woutrina Smith, Douglas R. Call

“…Detection of these public health-relevant conjugative plasmids and antibiotic resistant traits in Tanzanian water suggests the possible pollution of these water sources from human, livestock, and wild animal wastes and also shows the potential of these water sources in the maintenance and transmission of these resistance traits between environments, animals, and people.…”
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Automated Measurements of Tooth Size and Arch Widths on Cone-Beam Computerized Tomography and Scan Images of Plaster Dental Models by Thong Phi Nguyen, Jang-Hoon Ahn, Hyun-Kyo Lim, Ami Kim, Jonghun Yoon

“…An analysis of variance test confirmed the statistical consistency between the method’s measurements and those of human experts.…”
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Χαρτοφυλάκιον/Scrinium: An integrating activity for monitoring and assessing the learning of classical languages by Sofía Villegas-Rodríguez, Ronald Forero-Álvarez, Fernando Alexander Calderón-Velasco

“…This paper is a product of the project Proteus I: Development of Virtual Environments for Experiential Learning in the Humanities.…”
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Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway by Huabing Yang, Pengjun Zhao, Shiliu Tian

“…In the present study, human aortic endothelial cells (HAECs) were employed to explore the anti-inflammatory activity of INN. …”
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Machine Learning-Based Diabetes Risk Prediction Using Associated Behavioral Features by Ayodeji O. J. Ibitoye, Joseph D. Akinyemi, Olufade F. W. Onifade

“…With different uncertainties in human lifestyles, it is difficult to predict diabetes while assuming that the risk patterns are the same for all. …”
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دور دار الوثائق القومیة فى التسویق للتراث الوطنى الوثائقى فى مصر : دراسة تحلیلیة by د. مریم صالح منصور

“…National archives play a pivotal role in documenting the historical memoryof human beings and have the capacity to change the social, economic andpolitical development of the people. …”
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Monitoring ocular disease via optical nanostructures potentially applicable to corneal contact lens products by Bader AlQattan, Mohamed Elsherif, Fahad Alam, Haider Butt

“…A spherical surface was also used to simulate the human eye, and application of a force (curvature change) caused the nanostructure spacing to change, influencing the visible color of the contact lenses. …”
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HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas by M. J. Rutten, F. Dijk, C. D. Savci-Heijink, M. R. Buist, G. G. Kenter, M. J. van de Vijver, E. S. Jordanova

“…Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. …”
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Households willingness to pay for improved solid waste management by S. Akhtar, A.S. Ahmad, M.I. Qureshi, S. Shahraz

“…Waste is a byproduct of human life. Nowadays, municipal solid waste is being produced in excessive amounts and in this way, both developing and developed countries are facing challenges regarding generation of waste. …”
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Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer by Yugang Wu, Min Jin, Huanbai Xu, Zhang Shimin, Songbing He, Liang Wang, Yanyun Zhang

“…We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P=.028 for HIF-1/CXCR4, P=.007 for HIF-1/VEGF, and P=.004 for CXCR4/VEGF) had stronger correlation with lymph node metastasis than did each alone. …”
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Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants by Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki

“…Genomic variation can be quite significant, as seen by the notable differences in impact, transmission rate, morbidity, and death during several human coronavirus outbreaks. Therefore, understanding the amount and characteristics of coronavirus genetic diversity in historical and contemporary strains can help researchers get an edge over upcoming variants.…”
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