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  1. 3701

    USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells by Vignesh Srinivasan, Rabah Soliymani, Larisa Ivanova, Ove Eriksson, Nina Peitsaro, Maciej Lalowski, Mati Karelson, Dan Lindholm

    Published 2025-02-01
    “…Ubiquitin specific protease-14 (USP14) is critical for controlling proteostasis disturbed in human disorders, including Parkinson's disease (PD). …”
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    Feedback Artificial Shuffled Shepherd Optimization-Based Deep Maxout Network for Human Emotion Recognition Using EEG Signals by K. S. Bhanumathi, D. Jayadevappa, Satish Tunga

    Published 2022-01-01
    “…Emotion recognition is very important for the humans in order to enhance the self-awareness and react correctly to the actions around them. …”
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    Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs by Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan Howard, Felix Dalwigk, Reza Maroofian, Stephanie Efthymiou, Patricia Chan, Sergei I. Eliseev, Zi Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie M. Kaiser, Todd M. Lowe, Dragony Fu

    Published 2025-01-01
    “…These findings uncover unexpected roles for TRMT1 paralogs, decipher functions for m2,2G modifications, and pinpoint tRNAs dysregulated in human disorders caused by tRNA modification deficiency.…”
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  16. 3716

    Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms by E. V. Ignatieva, E. A. Matrosova

    Published 2021-03-01
    “…Most of the variants identified by the GWAS technique are located in the noncoding regions of the human genome. According to the ENCODE project, the fraction of regions in the human genome potentially involved in transcriptional control is many times greater than the fraction of coding regions. …”
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  17. 3717

    Developing a priority global research agenda for antimicrobial resistance in the human health sector: protocol for a scoping review by Alessandro Cassini, Raph L Hamers, Koe Stella Asadinia, Silvia Bertagnolio

    Published 2022-06-01
    “…Introduction To accelerate the response to the public health threat by antimicrobial resistance (AMR), the WHO is developing a Global Research Agenda for AMR in the human health sector that aims to provide a global and transparent assessment of priority knowledge gaps related to critical bacteria—including Mycobacterium tuberculosis—and fungi that inform control and response strategies to tackle AMR by 2030. …”
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