Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…In vitro, we established the cellular model of osteogenesis of human aortic smooth muscle cells (HASMCs) under phosphate conditions. …”
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TaWI12 may be involved in pistillody and leaf cracking in wheat by Yuhuan Guo, Yan Zhang, Yuhao Li, Yichao Wu, Mingli Liao, Zhengsong Peng, Zaijun Yang, Yonghong Zhou

“…Wheat (Triticum aestivum L.) is a crucial staple crop upon which human sustenance relies. Consequently, investigating the developmental mechanisms of pistils and stamens in wheat is profoundly significant for enhancing wheat characteristics and boosting productivity. …”
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Improvement of soil quality through biochar in rice under wastewater irrigated soil: Effects on heavy metals reduction by Sayon Mukherjee, Satish Kumar Singh, Raimundo Jiménez Ballesta, Abhik Patra, Surendra Singh Jatav

“… Purpose: Rice, a global staple, can accumulate high levels of heavy metals especially Chromium (Cr) when grown in a soil irrigated with tannery effluent over time, potentially reaching toxic levels for human consumption. Biochar offers a cost-effective solution by binding these heavy metals in soil, reducing their bioavailability and mitigating health risks. …”
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Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…Water quality deterioration in reservoirs threats human drinking water safety. It can be influenced by the macro-processes of meteorology, hydrology, and pollution. …”
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Considerations for determining warm-water coral reef tipping points by P. Pearce-Kelly, A. H. Altieri, J. F. Bruno, C. E. Cornwall, M. McField, A. I. Muñiz-Castillo, J. Rocha, R. O. Setter, C. Sheppard, R. M. Roman-Cuesta, C. Yesson

“…<p>Warm-water coral reefs are facing unprecedented human-driven threats to their continued existence as biodiverse functional ecosystems upon which hundreds of millions of people rely. …”
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Antimicrobial peptide Hs02 with rapid bactericidal, anti-biofilm, and anti-inflammatory activity against carbapenem-resistant Klebsiella pneumoniae and Escherichia coli by Deyi Zhao, Miran Tang, Panjie Hu, Xiaowei Hu, Weijun Chen, Zhexiao Ma, Huanchang Chen, Haifeng Liu, Jianming Cao, Tieli Zhou

“…The present research highlights a gap in the current literature regarding the mechanisms by which the intragenic antimicrobial peptide Hs02, derived from human proteins, exerts its rapid bactericidal and anti-inflammatory effects. …”
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An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…We have engineered a non-replicative AdV vector that produces HMGB1 Box A, an antagonist of HMGB1-induced inflammation, under the control of an endogenous complement component C3 (C3) promoter sequence, that is inducible by LPS and influenza in vitro and ex vivo in macrophages (Mϕ) and protects mice and cotton rats therapeutically against infection with mouse-adapted and human non-adapted influenza strains, respectively, in vivo. …”
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Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway by Minxia Zuo, Cheng Meng, Qian Song, Zhongai Gao, Xiao Cui, Jingyu Wang, Yongmei Li, Xiaochen Li, Chunyan Shan, Juhong Yang, Baocheng Chang

“…Beta-hydroxybutyric acid (BOHB), an AKT activator, an AKT inhibitor, or plasmids encoding DAB2 were transformed into human renal proximal tubule epithelial cells (HK-2 cells). …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Wheat has a pivotal role in food chains and human diet, and the understanding of its productive and qualitative performance under elevated CO2 (e[CO2]) is therefore a primary research target. …”
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Realizing collective action in agency-constrained contexts: the case of the Community Fish Refuges in Cambodia by Carla Rene Baldivieso Soruco, Carla Rene Baldivieso Soruco, Carla Rene Baldivieso Soruco, Sanjiv De Silva, Pia Gleich, Yin Yan, Mark Dubois, Stefan Sieber, Stefan Sieber, Michelle Bonatti, Michelle Bonatti, Michelle Bonatti

“…Structural factors and the deeply human process of pulling together a plurality of stakeholders pose challenges to establishing community-based projects prioritizing diverse voices.…”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Background: Exposure to brominated flame retardants (BFRs) may negatively impact human health. The association of BFRs with nonalcoholic fatty liver disease (NAFLD) in the general population is unclear. …”
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Prevalence and Molecular Characterization of Cysticercus tenuicollis Isolated from Some Intermediate Host in Kurdistan-Iraq by Abdullah Ahmed Hama, Rostam Hama Zorab, Fatima Mohammed Ali, Awaz M. Salih, Amer Abdullah Hassan

“…Cysticercus tenuicollis (C. tenuicollis) is the larval stage infection of Taenia hydatigena, a common tapeworm of dogs and other Canidae, which has a wide range of intermediate hosts including sheep, goat, cattle, deer, camel, horse, human and other wild ruminants, the disease spreads through a contaminated water, soil and food with feces of infected dogs or other carnivores, T. hydatigena lives in the intestinal of the definitive host (carnivores) and excretes a huge number of eggs with feces daily. …”
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Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…Pseudomonas aeruginosa is a hard-to-treat human pathogen for which new antimicrobial agents are urgently needed. …”
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Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury by Achi Haider, Susan Bengs, Angela Portmann, Sandro Fröhlich, Dominik Etter, Monika Maredziak, Geoffrey I. Warnock, Alexander Akhmedov, Sebastian Kozerke, Claudia Keller, Fabrizio Montecucco, Bruno Weber, Linjing Mu, Ronny R. Buechel, Vera Regitz-Zagrosek, Philipp A. Kaufmann, Giovanni G. Camici, Simon M. Ametamey, Catherine Gebhard

“…Further research is warranted to confirm these findings in humans.…”
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Agro Climatic Feasibility Rosa damascena mill Cultivation in Climate Change Condition in northern part of Isfahan Province Zahra sadat Jalali Chiomeh by zahra sadat Jalali Chimeh, Amir Gandomkar, Morteza Khodagholi, Hossein Battoli

“…Agriculture, as one of the most important human economic activities, is closely related to the climatic conditions, and any changes in the climatic conditions can have dramatic changes in agriculture. …”
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Impact of COVID-19 on the Air Quality over China and India Using Long-term (2009–2020) Multi-satellite Data by Manish Soni, Sunita Verma, Hiren Jethava, Swagata Payra, Lok Lamsal, Priyanshu Gupta, Janhavi Singh

“…Therefore, it is important to further strengthen environmental policies to tackle air quality, human health, and climate change in this part of the world.…”
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TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis by Haitao Li, Haitao Li, Yuanyuan Chu, Yuanyuan Chu, Liyuan Jiang, Liyuan Jiang, Lei Li, Lei Li, GuoDong Lv, Yuansheng Liu, Chunhou Zheng, Chunhou Zheng, Yansen Su, Yansen Su

“…Echinococcosis is a zoonotic parasitic disease caused by the larvae of echinococcus tapeworms infesting the human body. Drug combination therapy is highly valued for the treatment of echinococcosis because of its potential to overcome resistance and enhance the response to existing drugs. …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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Safety and Efficacy of Incorporating Actellic^® 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda by Tonny Jimmy Owalla, Emmanuel Okurut, Kenneth Ssaka, Gonsaga Apungia, Barbara Cemeri, Andrew Akileng, Basil Ojakol, Mark J. I. Paine, Hanafy M. Ismail, Thomas G. Egwang

“…Entomological indices were assessed using pyrethrum spray catching, CDC light traps and human landing catches. The Actellic^® 300 CS toxicity on acetylcholinesterase activity among applicators of HD4MC was evaluated using the Test-mate (Model 400) erythrocyte acetylcholinesterase (AChE) test V.2, whereas toxicity in household occupants was monitored clinically. …”
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Chemical composition and insecticidal activity of Mentha rotundifolia and Chrysanthemum coronarium essential oils against the tomato leaf miner, Tuta absoluta by Krache Farial, Boualem Malika, Benourad Fouzia, Touzout Nabil, Mihoub Adil, Subhan Danish, Sulaiman Ali Alharbi, Mohammad Javed Ansari, Abdullah A. Alarfaj

“…Their use is consistent with an environmentally responsible framework that reduces adverse impacts on ecosystems, protects non-target organisms, safeguards human health, and enhances the efficacy of integrated crop management systems. …”
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