Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. …”
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High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma by Bo Wu, Haihua Yang, Shenpeng Ying, Hongsheng Lu, Wei Wang, Jiaming Lv, Huacai Xiong, Wei Hu

“…The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). …”
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Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–20... by Getahun Kahsay Abay, Mebrahtu Teweldemedhin Shfare, Teklay Gebrecherkos Teklu, Kibriti Mehari Kidane, Tsega Kahsay Gebremeskel, Atsebaha Gebrekidan Kahsay, Kebede Embaye Gezae, Saravanan Muthupandian, Tsehaye Asmelash Degene

“…Due to their multidrug resistance attributes, the WHO has classified extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE)-associated infections as infections of critical significance, posing a serious risk to human health. Thus, the goal of this systematic review and meta-analysis was to assess the pooled prevalence of ESBL-PE and AMR among strains causing clinical infections in Africa. …”
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Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori by Fen Wang, Xiang Wu, Zhiying Liu, Guangkui Bu, Xiayu Li, Nanfang Qu, Jin Peng, Canxia Xu, Shourong Shen, Yi Yuan

“…CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor–associated factor 1 (TRAF1), tumor necrosis factor receptor superfamily member 9 (4-1BB), and B-cell lymphoma-extra large (Bcl-xL) in human gastric epithelial cells. We investigated the correlation between cagA/vacAs1/vacAm1 and TRAF1/4-1BB/Bcl-xL expression in gastric mucosal tissue of patients with gastric disorders. …”
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DEmiRNA-mRNA regulatory network reveals miR‐122-5p as a regulatory factor of arginine metabolism in necrotizing enterocolitis by Zhili Ding, Ting Guo, Qiang Tang, Yaqiang Hong, Zhibao Lv, Li Lu, Wenjun Zhuang

“…The miR-122-5p activation was explored in vitro in the human intestinal epithelial cell (FHs74Int) and rat intestinal epithelial cell (IEC-6). …”
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Distinctive dust weather intensities in North China resulted from two types of atmospheric circulation anomalies by Q. Huo, Q. Huo, Z. Yin, Z. Yin, Z. Yin, X. Ma, X. Ma, H. Wang, H. Wang, H. Wang

“…<p>Dust weather in North China (NC; 34–42° N, 105–120° E) has worsened in recent years, posing adverse impacts on the environment, human health, and the economy. A super dust storm that occurred on 15 March 2021 raised Beijing's PM<span class="inline-formula">₁₀</span> (particulate matter with a diameter less than 10 <span class="inline-formula">µ</span>m) concentrations above 7000 <span class="inline-formula">µ</span>g m<span class="inline-formula">⁻³</span>, while 2023 witnessed the highest spring dust weather frequency in nearly a decade. …”
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Real-time seizure detection in paediatric intensive care patients: the RESET child brain protocol by Kristen Gibbons, Andreas Schibler, Anthony Slater, Louise Sparkes, Michaela Waak, Stephen Malone, Jane Harnischfeger, Sandra Gurr

“…To calculate 95% (CIs) around the sensitivity and specificity estimates with a CI width of 10%, the sample size needed for sensitivity is 80 patients assuming each EEG will have approximately 9 to 18 1-hour epochs.Ethics and dissemination The study has received approval by the Children’s Health Queensland Human Research Ethics Committee (HREC/19/QCHQ/58145). …”
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Tuberculosis and COVID-19: Lessons from the Past Viral Outbreaks and Possible Future Outcomes by Radu Crisan-Dabija, Cristina Grigorescu, Cristina-Alice Pavel, Bogdan Artene, Iolanda Valentina Popa, Andrei Cernomaz, Alexandru Burlacu

“…The threat of contagious infectious diseases is constantly evolving as demographic explosion, travel globalization, and changes in human lifestyle increase the risk of spreading pathogens, leading to accelerated changes in disease landscape. …”
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Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia by Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Cristina Banfi, Stefania Ghilardi, Arianna Greco, Maria Luisa Biondi, Sara Rovai, Elisabetta Mancini, Sergio Harari, Piergiuseppe Agostoni

“…Background The COVID-19 pandemic has led to significant concern due to its impact on human health, particularly through pneumonia-induced lung damage. …”
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RNA-Sequence Reveals the Regulatory Mechanism of miR-149 on Osteoblast Skeleton under Mechanical Tension by Yifan Wang, Guanyin Zhu, Fang Pei, Yigan Wang, Jun Liu, Caixia Lu, Zhihe Zhao

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for enrichment analysis. Human osteoblast MG63 was treated with 5000 U mechanical tension. …”
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A Bore-Integrated Patch Antenna Array for Whole-Body Excitation in Ultra-High-Field Magnetic Resonance Imaging by Svetlana S. Egorova, Nikolai A. Lisachenko, Egor I. Kretov, Yang Gao, Xiaotong Zhang, Stanislav B. Glybovski, Georgiy A. Solomakha

“…The human body&#x2019;s ultra-high field magnetic resonance imaging suffers from the inhomogeneity of the radio frequency magnetic field <inline-formula> <tex-math notation="LaTeX">$B_{1}^{+}$ </tex-math></inline-formula> and the high-peak levels of SAR created in body tissues during transmission. …”
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Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer by Huanrong Ma PhD, Jingjing Wu Bachelor, Minyu Zhou PhD, Jianhua Wu PhD, Zhenzhen Wu PhD, Li Lin PhD, Na Huang PhD, Wangjun Liao PhD, Li Sun PhD

“…The results of MTT assay showed that by glutamine deprivation or inhibition of glutamine uptake, the viability of gastric carcinoma cells was inhibited more severely than that of human immortal gastric mucosa epithelial cells (GES-1). …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 3; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. …”
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Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…In vitro incubation with pMSC-conditioned medium prevented cell death in cultured human peritoneal mesothelial cells (HPMCs) and downregulated proinflammatory (i.e., CXCL6, NOS2, IL1RN, CCL5, and NR3C1) while upregulated anti-inflammatory (i.e., CCR1, CCR4, IL9, and IL-10) gene expression in activated THP1 cells. …”
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Spatiotemporal evolution and driving factors of the synergistic effects of pollution control and carbon reduction in China by Qinggang Meng, Xiaolan Chen, Hui Wang, Wanfang Shen, Peixin Duan, Xinyue Liu

“…Green innovation, digital economy, energy intensity, and human capital drivers showed a clear east–west zonal distribution. …”
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Screening Southeast Asian medicinal plants: Clausena lansium, Leea indica, Strobilanthes crispa, Vitex trifolia for anti-platelet aggregation and blood coagulation effects by Sogand Zareisedehizadeh, Fu-Xun Heng, Chay-Hoon Tan, Paul Chi-Lui Ho, Hwee-Ling Koh

“…Platelet aggregation was analyzed using collagen-induced aggregation in human whole blood. Anticoagulant activities were evaluated by determining the effects on prothrombin time (PT) and activated partial thromboplastin time (aPTT). …”
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The role of mNGS in the diagnosis of talaromycosis and case series by Jing Zhao, Hui-Ting Su, Dong Zhang, Xue-Tong Li, Min-Ya Lu, Juan Du, Jia-Yu Guo, Yi Gao, Xin-Fei Chen, Dong-Hua Wen, Shi-Yu Jia, Yao Wang, Qi-Wen Yang

“…Results Among the four patients, two were human immunodeficiency virus (HIV)-positive, and two were HIV-negative. …”
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Blue applicability grade index assessment and response surface modelling to synchronous determination of metformin hydrochloride, vildagliptin and dapagliflozin propanediol monohyd... by Pintu Prajapati, Krutika Patil, Dhrumi Naik, Veera Shakar Pulusu, Anzarul Haque, Mohd Abul Kalam, Shailesh Shah

“…Abstract Diabetes mellitus is major chronic disease found in human due to stressful lifestyle and bad food habit. …”
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Phytotoxicity and phytoremediation potential of Lemna minor exposed to perfluorooctanoic acid by Azam Noori, Lorena Corbelli, Erin Lincoln, Sara Thomas, Jasmine Jones, Sara L. Nason, Jason C. White, Riley Lewis, Christy L. Haynes

“…Perfluorooctanoic acid (PFOA) is one of the highly toxic compounds which was phased out of application in consumer products in 2015 due to its harmful effects on human and environmental health. However, this chemical was in use for many years and is still found in water resources. …”
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Single Nucleotide Polymorphisms in TLR4 Affect Susceptibility to Tuberculosis in Mexican Population from the State of Veracruz by Enrique Ortega, Sujhey Hernández-Bazán, Beatriz Sánchez-Hernández, Ileana Licona-Limón, Javier Fuentes-Dominguez

“…Tuberculosis is still a global public health problem, with an estimated 10 million new cases and 1.6 million deaths in 2017. Of all humans infected with M. tuberculosis, only 10-15% will develop active tuberculosis disease during their lifetime, and data suggest that along with environmental factors, genetic factors influence susceptibility to develop active disease. …”
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