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Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells
Published 2015-01-01“…Tuberculosis (TB) remains a serious global public health problem that results in up to 2 million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis (Mtb), which infects primarily innate immune cells patrolling the lung. …”
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3183
Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells
Published 2021-01-01“…In this study, we aimed to examine the anti-inflammatory effects of nobiletin on tumor necrosis factor- (TNF-) stimulated human periodontal ligament cells (HPDLCs). Our results demonstrated that nobiletin treatment could decrease the expressions of inflammatory cytokines (C-X-C motif chemokine ligand (CXCL)10, C-C motif chemokine ligand (CCL)2, and interleukin- (IL-) 8), matrix metalloproteinases (MMPs) (MMP1 and MMP3), and prostaglandin-endoperoxide synthase 2 (PTGS2) in TNF-stimulated HPDLCs. …”
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3184
Critical linkages between land use change and human health in the Amazon region: A scoping review.
Published 2018-01-01“…Our research aims to examine the current state of evidence on the link between LUC and human health in the Amazon region. We conducted a scoping review of literature in two research databases, resulting in 14 papers for analysis. …”
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3185
In defence of South Africa’s National Health Research Ethics Council guidelines on heritable human genome editing
Published 2025-02-01Subjects: “…heritable human genome editing…”
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3187
VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2
Published 2013-01-01“…In this study, human GBSCs were isolated from surgical specimens of glioblastoma and cultured in medium favored for stem cell growth. …”
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3188
Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A
Published 2018-01-01“…To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). …”
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3189
Tackling antimicrobial resistance in Bangladesh: A scoping review of policy and practice in human, animal and environment sectors.
Published 2020-01-01“…We used Google Scholar, Pubmed, and Biomed Central databases for searching peer-reviewed literature in human, animal and environment sectors during January 2010-August 2019, and Google for grey materials from the institutional and journal websites. …”
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3190
New discoveries of Middle Paleolithic human remains from the “Bau de l'Aubésier (Vaucluse, France)”
Published 2001-06-01“…The Middle Pleistocene remains (Aubesier 10 and 11) have close morphological affinities to contemporaneous European human remains, and the Neandertal molar (Aubesier 12) falls well within Neandertal ranges of variation. …”
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3191
Assessment of Human-originated Medroxyprogesterone Acetate (MPA) as Effective Contraceptive in Domesticated Queens (Felis catus) in Iraq
Published 2024-12-01“…This study investigated the use of medroxyprogesterone acetate (MPA), precisely the human formulation Depo-Provera®, as a potential solution for feline contraception. …”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery
Published 2024-12-01“…We have developed transgenic chickens expressing heavy chain-only antibodies with a human variable region to combine the superior target recognition advantages of a divergent, non-mammalian host with the ability to discover single-domain binders. …”
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Perancangan Pengalaman Pengguna Portal Job Fair Sarjana Sakti dengan Pendekatan Human-Centered Design
Published 2022-12-01“…Aplikasi ini dirancang dengan menggunakan pendekatan Human-Centered Design (HCD) karena memiliki strategi desain yang iterative untuk mendapatkan hasil yang diharapkan. …”
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Sensitivity analysis of a mathematical model for malaria transmission accounting for infected ignorant humans and relapse dynamics
Published 2025-01-01“…This article presents and analyzes a deterministic model for malaria transmission that incorporates infected individuals who are unaware of their infectious status (ignorant infected humans) and accounts for relapse dynamics. We explore the invariant region and positivity of the model and calculate the effective reproduction number using the next-generation matrix method. …”
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Assessment of Protective Effects of Carvacrol on Haloperidol-Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes
Published 2022-01-01“…Therefore, using carvacrol as a natural antioxidant protected human lymphocytes against haloperidol genetic damage.…”
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TNF-α Regulates Natriuretic Peptides and Aquaporins in Human Bronchial Epithelial Cells BEAS-2B
Published 2013-01-01“…Here, we showed that TNF-α selectively regulates key molecules involved in fluids balance, such as natriuretic peptides (NPs) and aquaporins, in human bronchial epithelial cells BEAS-2B. In particular, we found that TNF-α induced a decrease of arial natriuretic peptide, natriuretic peptide receptor-1, aquaporin-1 and aquaporin-5 and an increase of brain natriuretic peptide with a different involvement of nuclear factor-κB and mitogen-activated protein kinases signaling pathway activation. …”
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Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics
Published 2025-01-01“…We present a series of cryo-EM structures of human TOP3B with its cofactor TDRD3 during cleavage and rejoining of DNA or RNA, thus elucidating the roles of divalent metal ions and key enzyme residues in each step of the catalytic cycle. …”
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3198
Phospholipase A2 Mediates Apolipoprotein-Independent Uptake of Chylomicron Remnant-Like Particles by Human Macrophages
Published 2012-01-01“…To investigate these mechanisms, triacylglycerol (TG) accumulation induced by apolipoprotein-free chylomicron remnant-like particles (CRLPw/o) in human monocyte-derived macrophages was evaluated. …”
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Silk of the Indian meal moth Plodia interpunctella (Hübner, 1813) affects the human colon cancer cells
Published 2024-01-01“…The selective effect of silk indicates the presence of a high level of biocompatibility with normal human cells. Based on the results of increased gene expression for caspase 8 and 9 in silk extract-treated cells compared to control, apoptosis was induced by a caspase-dependent pathway.…”
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Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria
Published 2016-01-01“…Trypanosoma brucei gambiense causes Gambian trypanosomosis, a disease ravaging affected rural parts of Sub-Saharan Africa. We screened 1200 human blood samples for T. b. gambiense using the card agglutination test for trypanosomosis, characterized trypanosome isolates with Trypanosoma gambiense serum glycoprotein-PCR (TgsGP-PCR), and analyzed our data using Chi square and odds ratio at 95% confidence interval for statistical association. …”
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