Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization by Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang, Ying Wang, Xiyun Yan, Kelong Fan

“…Here, we identify transferrin receptor 1 (TfR1) as an upregulated target in NPC, with its expression levels positively correlated with hypoxia. Human heavy-chain ferritin, a specific ligand of TfR1, selectively recognizes hypoxic NPC lesions in preclinical models. …”
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Comparative Analysis of Gradient Descent Learning Algorithms in Artificial Neural Networks for Forecasting Indonesian Rice Prices by Rica Ramadana, Agus Perdana Windarto, Dedi Suhendro

“…Artificial Neural Networks (ANN) are a field of computer science that mimics the way the human brain processes data. ANNs can be used to classify, estimate, predict, or simulate new data from similar sources. …”
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RF-AIRCGR: Lightweight Convolutional Neural Network-Based RFID Chinese Character Gesture Recognition Research by Yajun Zhang, Congcong Wang, Feng Li, Weiqian Yu, Yuankang Wang, Jingying Chen

“…Gesture recognition serves as a foundation for Human-Computer Interaction (HCI). Although Radio Frequency Identification (RFID) is gaining popularity due to its advantages (non-invasive, low-cost, and lightweight), most existing research has only addressed the recognition of simple sign language gestures or body movements. …”
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Temporal-spatial Evolution of Drought Characteristics at Different Grades in Yulin by KONG Gang, ZHANG Shanliang, WANG Lu, HUANG Shengzhi, BAI Jueying

“…Under the background of climate warming and human activities,Yulin city suffers from frequent drought,which has adverse effect on the agriculture,ecological environment and social economy in this area.Although the adverse effects of drought on the Loess Plateau have attracted the attention of many scholars,there is still a lack of grid and refined spatial and temporal assessment of drought in Yulin City.Therefore,taking Yulin City as the study area,based on the monthly precipitation and soil moisture data with a spatial resolution of 0.25°×0.25°,this paper calculates the standardized precipitation index (SPI) and the standardized soil moisture index (SSMI) on three month scales,identifies the drought characteristic parameters by the run theory,and analyzes the spatial-temporal evolution of drought characteristics at different grades.The results show that:The drought is rigorous in Yulin city.In time,a wet trend appears in spring and winter,while a dry trend in summer.In space,there is a significant dry trend in the southern of Yulin city.There are more than 6 months of long-term precipitation deficit and 12 months of long-term soil moisture deficit in Yulin City,respectively,and the month with consecutive precipitation deficit come earlier than the soil moisture deficit.Areas with high drought frequency are located in the northern,southern and eastern edges of Yulin.The conclusion is of great significance to the drought prevention,social production and ecological environment in Yulin city.…”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…Investigations of experimental enterocolites and human IBD confirm immunologic hypothesis of pathogenesis: relation of their development to defects of innate and adaptive immune system.…”
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Spatial and Temporal Characteristics of Precipitation and Runoff Response in Yalong River Basin by CHANG Xinyu, LIU Bin, JIA Yugong, FU Zhiyu

“…Under the dual influence of climate change and human activities,extreme climate occurs frequently around the world,and the precipitation in the studied basin has undergone profound changes,so it is necessary to further explore the inherent characteristics and variation laws of precipitation and runoff and thus enhance the understanding of the evolution laws of hydrological and meteorological elements in the basin under the changing environment.In this paper,Mann-Kendall nonparametric test,R/S analysis,moving t-test,and Morlet wavelet transform are introduced to analyze the interannual trend and identify abrupt changes and periodic characteristics of precipitation at meteorological stations in the Yalong River Basin in the past 50 years,and the response degree of runoff to precipitation is measured by correlation coefficient.The results show that the Hurst index of precipitation in the basin is greater than 0.5,and the precipitation trends at Qingshuihe,Shiqu,and Zhongdian stations are more significant;at the same time,due to the continuous influence of the changing environment,the precipitation in the basin has a multi-scale significant period in both time and frequency domains,and the precipitation fluctuates during small periods of 1.0~2.5 years and large periods of 4~6 years.Besides,the meteorological stations with strong runoff responses to precipitation in the basin are obtained,and the precipitation trend of other stations is not significant except Zhongdian station.The research results can provide a scientific basis for selecting driving factors of the nonlinear runoff forecasting model.…”
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MENTAL BARRIERS TO REDUCE VULNERABILITY TO INJURY DURING A FALL: AN ELEMENTARY ISSUE OF PERSONAL SAFETY IN A GLOBAL CIVILIZATION by Bartłomiej Gąsienica-Walczak, Artur Kalina, Artur Litwiniuk, Joanna Baj-Korpak

“…The effects of unintentional human falls are seen as a serious public health problem. …”
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The Impact of Bioactive Lipids on Cardiovascular Development by Alexander Kleger, Stefan Liebau, Qiong Lin, Götz von Wichert, Thomas Seufferlein

“…Interestingly, S1P may also act to maintain human stem cell pluripotency. …”
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CiaBOT: the circular design of an experimental microarchitecture between material and immaterial values by Elena Montacchini, Silvia Tedesco, Nicolò Di Prima

“…Through the description of the different stages of the design process, the article is part of the debate on new sustainable ways of designing and building, reflecting on new models of circular economy based as much on design strategies and processes as on the enhancement of human labor and the use of technologies appropriate to the context and actors.…”
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Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…This is the first report to show that inflammation and ER stress downregulate the expression of BDH2 in human THP-1 macrophages.…”
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Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers by Che-Yi Lin, Tien-Szu Pan, Chun-Chan Ting, Shih-Shin Liang, Shu-Hung Huang, Hsiu-Yueh Liu, Edward Cheng-Chuan Ko, Chung-Wei Wu, Jen-Yang Tang, Ping-Ho Chen

“…Betel quid (BQ) products, with or without tobacco, have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. …”
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The Impact of Land Development Rights Transfer on Urban–Rural Spatial Justice: A Case Study of Chongqing’s Land Quota Trading by Siyi Wei, Jing Huang, Zhanlu Zhang

“…Spatial justice, as a fundamental value in social systems, plays a key role in achieving social justice and improving human well-being. Drawing on theories of spatial justice, property rights, and new institutional economics, this study explores the comprehensive impact of land development rights (LDR) transfer on urban–rural spatial economic, resources, social, and ecological equity from the perspective of urban–rural spatial justice. …”
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Potentials of Curcumin as an Antidepressant by S.K. Kulkarni, Ashish Dhir, Kiran Kumar Akula

“…Major depression, a debilitating psychiatric disorder, is predicted to be the second most prevalent human illness by the year 2020. Various antidepressants, ranging from monoamine oxidase inhibitors to recently developed dual reuptake inhibitors, are prescribed for alleviating the symptoms of depression. …”
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Urban greenspaces reduce the community specialization of soil nematodes by Justin Louis Kafana Coulibaly, Xin Gong, Yuanhu Shao, Huayuan Shangguan, Alexis Kayiranga, Ismail Koné, Yanjiang Cai, Xin Sun

“…Furthermore, our results showed that human density, as a proxy of urbanization intensity, was linked to changes in soil pH between land use types. …”
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Critical Theory and Constructivism in the Perspective of Islamic Epistemology by Noza Aflisia, Hendrianto Hendrianto, Nanat Fatah Nasir, Erni Haryanti

“…In Islamic epistemology it is believed that humans not only know physical objects, but also non-physical objects. …”
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Quantitative Analysis of the Proteome and the Succinylome in the Thyroid Tissue of High-Fat Diet-Induced Hypothyroxinemia in Rats by Baoxiang Hu, Meng Zhao, Dandan Luo, Chunxiao Yu, Shanshan Shao, Lifang Zhao, Yashuang Yang, Xiaohan Zhang, Jiajun Zhao, Ling Gao

“…Finally, the mitochondrial oxygen consumption rates of human normal thyroid epithelial cells were measured to further verify the role of lysine succinylation. …”
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Green Space Planning and Landscape Sustainable Design in Smart Cities considering Public Green Space Demands of Different Formats by Juan Shan, Zhuo Huang, Sibo Chen, Yue Li, Wenli Ji

“…Smart UGS planning is a technical management tool and a human-centered smart application. A novel UGS classification method based on function combinations is proposed in the present work. …”
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Complementary feeding and the early origins of obesity risk: a study protocol by Daniel D Reidpath, Ireneous N Soyiri, Naleena Devi Muniandy, Pascale A Allotey

“…For the qualitative strand, selected mothers will be interviewed to explore their infant feeding practices and factors that influence their practices and food choices in detail.Ethics and dissemination Ethical clearance for this study was sought through the Monash University Human Research and Ethics Committee (application number CF14/3850-2014002010). …”
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Use of Magnetic Nanoparticles as Targeted Therapy: Theranostic Approach to Treat and Diagnose Cancer by Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi

“…To overcome the uncontrolled growth of the proliferating cells, nanosystems have been developed and have undergone many preclinical trials both in vitro and in vivo and many practices have been further applied clinically on human beings. In practice, magnetic nanoparticles- (MNPs-) based systems following the application of Fe3O4 bound antitumor drug have shown an enhanced therapeutic index in comparison with conventional chemotherapy ensuring the significant decline in nanosystems’ toxicity. …”
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Developing the Preventing Model of Transnational Crimes in Russia and Indonesia in the Age of Sanctions and Global Economic Instability by Toebagus Galang Windi Pratama, Ruslan Puzikov, Sergey Lantsov, Vadim Ponkratov, Ekaterina Khomenko, Larisa Vatutina, Gustavo Henrique Rodrigues Pessoa

“…This study reveals novel insights into the distinct patterns of transnational crime: Russia primarily faces cybercrime, economic offenses, and money laundering, while Indonesia grapples with human trafficking, environmental crimes, and maritime piracy. …”
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