Human Diseases and Microbes

“… Human diseases are enormous and more varied than the human kind himself. …”
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Complement in Human Disease by Michael A. Flierl, Daniel Rittirsch, Markus S. Huber-Lang, Philip F. Stahel

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Protein Misfolding and Human Disease by Christopher Dobson

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Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. …”
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Structural Variation of Element and Human Disease by Songmi Kim, Chun-Sung Cho, Kyudong Han, Jungnam Lee

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The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

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Phylostratigraphic analysis of gene networks of human diseases by Z. S. Mustafin, S. A. Lashin, Yu. G. Matushkin

“…Using the Orthoscape application, gene networks from the KEGG Pathway, Human Diseases database describing various human diseases were analyzed. …”
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Mechanisms of Copper-Induced Autophagy and Links with Human Diseases by Yuanyuan Fu, Shuyan Zeng, Zhenlin Wang, Huiting Huang, Xin Zhao, Min Li

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Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases by Jiaxin Wu, Rui Jiang

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Targeting TLR/IL-1R Signalling in Human Diseases by Maria Loiarro, Vito Ruggiero, Claudio Sette

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AAV-based vectors for human diseases modeling in laboratory animals by Timur I. Aliev, Dmitry V. Yudkin

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Alteration of Immune-Mechanisms by Human Microbiota and Development and Prevention of Human Diseases by Mitesh Dwivedi, Ansarullah, Ilian Radichev, E. Helen Kemp

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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

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The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms by Ho-Sun Lee

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Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers by Xudong Zou, Zhaozhao Zhao, Yu Chen, Kewei Xiong, Zeyang Wang, Shuxin Chen, Hui Chen, Gong-Hong Wei, Shuhua Xu, Wei Li, Ting Ni, Lei Li

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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…This review examines the regulatory mechanisms and pathological implications of pseudouridylation in human diseases, with a focus on its involvement in tumourigenesis. …”
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Application of Whole Exome Sequencing to Identify Disease-Causing Variants in Inherited Human Diseases by Gerald Goh, Murim Choi

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Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review by Brijesh Singh Chauhan, Yash Pal Singh

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The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases by Faris Azzouni, Alejandro Godoy, Yun Li, James Mohler

“…Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…These important findings provide new avenues for further investigation of SYVN1 protein, new insights into potential strategies to prevent and treat human diseases, and new directions for future drug development.…”
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