Comparison of Classification Algorithms with Wrapper-Based Feature Selection for Predicting Osteoporosis Outcome Based on Genetic Factors in a Taiwanese Women Population by Hsueh-Wei Chang, Yu-Hsien Chiu, Hao-Yun Kao, Cheng-Hong Yang, Wen-Hsien Ho

“…An essential task in a genomic analysis of a human disease is limiting the number of strongly associated genes when studying susceptibility to the disease. …”
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Walking Gait Phase Detection Based on Acceleration Signals Using Voting-Weighted Integrated Neural Network by Lei Yan, Tao Zhen, Jian-Lei Kong, Lian-Ming Wang, Xiao-Lei Zhou

“…Human gait phase recognition is a significant technology for rehabilitation training robot, human disease diagnosis, artificial prosthesis, and so on. …”
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Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes. by Ranjit K Deka, Shih-Chia Tso, Wei Z Liu, Chad A Brautigam

“…Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. …”
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Mutational signature analysis predicts bacterial hypermutation and multidrug resistance by Kalen M. Hall, Leonard G. Williams, Richard D. Smith, Erin A. Kuang, Robert K. Ernst, Christine M. Bojanowski, William C. Wimley, Lisa A. Morici, Zachary F. Pursell

“…Mutational signature analysis of P. aeruginosa across different human disease contexts identified appreciable quantities of MMR-deficient clinical isolates that were already MDR or prone to future MDR acquisition. …”
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The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development. by Yangziwei Yu, Chuqiao Wang, Yan Wang, Heng Shi, Huiyuan Hu, Yibin Du, Zhaoli Zhou

“…CTU2 serves as a scaffold protein, while CTU1 catalyzes the 2-thiolation at the 34th wobble uridine of the anticodon loop. tRNAGlnUUG, tRNAGluUUC, and tRNALysUUU are the tRNA substrates that are modified with a thiol group at the C2 positions (s2) by CTU1, and also with a methoxycarbonylmethyl group at the C5 positions (mcm5) by Elongator and ALKBH8. mcm5s2U34 modification of the three tRNAs, and their modifying enzymes are involved in human disease and development. Elongator mutant animals exhibit severe phenotypes, while the biological function of Ctu1 in vertebrate animal models remains poorly characterized. …”
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RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome by Raghib Ashraf, Hana Polasek-Sedlackova, Victoria Marini, Jana Prochazkova, Zdenka Hasanova, Magdalena Zacpalova, Michala Boudova, Lumir Krejci

“…This underscores the importance of RECQ4-MUS81 in safeguarding genome integrity and suggests potential implications for human disease. Our findings demonstrate the RECQ4-MUS81 interaction as a key mechanism in alleviating replication stress at hard-to-replicate regions and highlight its relevance in pathological conditions such as RTS.…”
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Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on -statistics by Hae-Hiang Song, Hae-Jin Hu, In-Hae Seok, Yeun-Jun Chung

“…By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.…”
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Implementation and evaluation of online and offline blended teaching model in laboratory course of Clinical Laboratory Hematology by Dan Li, Fang Wang, Xiaodong Zhou, Kejun Peng, Limei Zhang, Hong Yan, Xiaoying Li, Juan Zhang

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From the guest editors by Gerardo Chowell, Zhilan Feng, Baojun Song

“…Specifically, he co-authored a textbook in Mathematical Biology in 2001 (second edition in 2012); a volume (with Harvey Thomas Banks) on the use of mathematical models in homeland security published in SIAM's Frontiers in Applied Mathematics Series (2003); and co-edited volumes in the Series Contemporary Mathematics entitled ``Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges'' (American Mathematical Society, 2006) and Mathematical and Statistical Estimation Approaches in Epidemiology (Springer-Verlag, 2009) highlighting his interests in the applications of mathematics in emerging and re-emerging diseases. …”
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Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma by Hong Yan, Nan Jiang, Xiaoying Li, Chenyang Lin, Fang Wang, Juan Zhang, Lijuan Chen, Dan Li

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Microbial and Inflammatory Salivary Biomarkers of Periodontal Diseases by Aram Mohammed Sha, Hayder Raad Abdulbaqi, Syed Saad Bin Qasim

“… Recent data reveals that severe periodontal diseases affect approximately 19% of global adult populations, impacting more than 1 billion individuals universally, ranking it as the sixth most predominant human disease. Diagnosis and treatment plans for periodontal disease entirely depend solely on the assessment of traditional clinical parameters. …”
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Choosing an Animal Model for the Study of Functional Dyspepsia by Yang Ye, Xue-Rui Wang, Yang Zheng, Jing-Wen Yang, Na-Na Yang, Guang-Xia Shi, Cun-Zhi Liu

“…However, it is unclear which of these models most closely mimic the human disease. This review provides a comprehensive overview of the currently available animal models of FD in relationship to the clinical features of the disease. …”
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GLOBAL PREVALENCE OF CHLAMYDIA INFECTION AMONG WILD BIRDS AS PUBLIC HEALTH CONCERNS: A SYSTEMATIC REVIEW AND META-ANALYSIS by T. I. Mamun, J. Rahman, M. J. Hossain, R. Hasan, M. T. Neoaj, M. M. Mia

“…Birds are frequently susceptible to the Chlamydia pathogen, which can lead to avian chlamydiosis and the human disease ornithosis. The present study investigated wild birds Chlamydia prevalence using a systematic review and meta-analysis. …”

Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure by Dahlia M. Nielsen, Mei Hsu, Michael Zapata, Giovanni Ciavarra, Leonel van Zyl

“…However, since the molecular pathogenesis of MM in mice accurately recapitulates that of human disease, this disconnect between functional and epidemiological studies can be overcome by using inbred mouse strains that harbor mutation(s) in genes involved in the disease. …”
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Structure and Function of the LRBA Protein by Ege Ezen, Mehmet Cihangir Çatak, Feyza Bayram Çatak, Sofia Piepoli, Pegah Zahedimaram, Ecem Ultanır, Safa Barış, Batu Erman

“…Family members such as LRBA, LYST and NBEAL2 are implicated in human disease. LRBA was shown to be responsible for the re-shuttling of the T-cell co-inhibitory receptor CTLA4 back to the plasma membrane after internalization and lack or mutation of LRBA results in surface deficiency of CTLA4 in regulatory and activated T lymphocytes. …”
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A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, Irene Li, Asmita Bhattacharya, Yuanyuan Li, Winston Trope, Joseph B. Shrager, Calvin Kuo, Michael G. Ozawa, Amato J. Giaccia, Lu Tian, Sylvia K. Plevritis

“…Our data show that assembloids recapitulate human LUAD tumor-stroma spatial organization, justifying their use as a tool for investigating the spatial biology of human disease. Intriguingly, drug-perturbation studies identify drug-induced spatial rearrangements that also appear in treatment-naïve human tumor samples, suggesting potential directions for characterizing spatial (re)-organization related to drug resistance. …”
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Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review by Pan Yang, Jing Li, Xiumei Ma, Nan Hu, Zhangyong Song, Bin Chen, Shizhu Li

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Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…The application of findings from mouse teeth to human disease remains insufficiently explored. Methods Leveraging multiple single-cell datasets, we constructed a comprehensive dental pulp cell landscape to delineate tissue similarities and species-specific differences between humans and mice. …”
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Reply to: comment on “Early cancer detection by serum biomolecular fingerprinting spectroscopy with machine learning” by Shilian Dong, Dong He, Qian Zhang, Chaoning Huang, Zhiheng Hu, Chenyang Zhang, Lei Nie, Kun Wang, Wei Luo, Jing Yu, Bin Tian, Wei Wu, Xu Chen, Fubing Wang, Jing Hu, Xiangheng Xiao

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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). The immunomodulatory activities of Taenia crassiceps excreted/secreted products (TcES) that may suppress EAE development were sought for. …”
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