TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit.…”
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Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD by Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer

“…Some conservation exists between alternative polyadenylation in rNLS8 mice and human disease models including in disease relevant genes and biological pathways. …”
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TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling by Rambon Shamilov, Brian J. Aneskievich

“…Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis. …”
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Unusual Methylobacterium fujisawaense Infection in a Patient with Acute Leukaemia Undergoing Hematopoietic Stem Cell Transplantation: First Case Report by Rosa Fanci, Giampaolo Corti, Alessandro Bartoloni, Enrico Tortoli, Alessandro Mariottini, Patrizia Pecile

“…Microorganisms of the genus Methylobacterium are facultative methylotrophic, gram-negative rods that are ubiquitous in nature and rarely cause human disease, mostly in subjects with preexisting causes of immune depression. …”
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Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…Experimental models that mimic human disease have been developed in order to study pathogenic and therapeutic mechanisms, but have shown mixed success in clinical application. …”
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Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis? by U. R. Goonetilleke, S. A. Ward, S. B. Gordon

“…The contribution of these pathways to human disease is unknown. Using proteomic techniques, neuronal death pathways could be described in CSF samples. …”
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Molecular–Genetic Imaging: A Nuclear Medicine–Based Perspective by Ronald G. Blasberg, Juri Gelovani Tjuvajev

“…The development of versatile and sensitive assays that do not require tissue samples will be of considerable value for monitoring molecular–genetic and cellular processes in animal models of human disease, as well as for studies in human subjects in the future. …”
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The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases by César Pacheco-Tena, Susana Aideé González-Chávez

“…Both roles are not mutually exclusive. Some examples in human disease and in animal models are provided based on current evidence.…”
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RETRACTED: Biodiversity Loss with Habitat and Risk of New Diseases by Darshit Ram

“…The maintenance of biodiversity is hypothesised to reduce pathogen prevalence and consequently human disease risk through the dilution effect. However, assuming microbial diversity correlates with that of all other life forms, there may be increased potential for novel pathogens to emerge from biodiverse regions. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Furthermore, iPS cell technology has generated new human disease models using disease-specific cells. This paper summarizes the progress of iPS cell technology in cardiovascular research.…”
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Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1 by Fan Zhang, Shaobai Li, Hao Wu, Shanshuang Chen

“…Here, we show biochemical and structural evidence that human Vangl1 oligomerizes as dimers of trimers, and that the dimerization of trimers promotes binding to the PCP effector Prickle1 (Pk1) in vitro. Mapping of human disease-associated point mutations suggests potential pathological mechanisms and paves the way for future studies on the importance of lipid binding, central vestibule and oligomerization of Vangl, thereby providing insights into the molecular mechanisms of the PCP signaling pathway.…”
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Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Epigenetic mechanisms play a role in human disease but their involvement in pathologies from the central nervous system has been hampered by the complexity of the brain together with its unique cellular architecture and diversity. …”
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Deep learning to decode sites of RNA translation in normal and cancerous tissues by Jim Clauwaert, Zahra McVey, Ramneek Gupta, Ian Yannuzzi, Venkatesha Basrur, Alexey I. Nesvizhskii, Gerben Menschaert, John R. Prensner

“…Abstract The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Accurate delineation of RNA translation variation represents a significant challenge due to the complexity of the process and technical limitations. …”
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Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease by Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst, Stine Reedtz-Runge

“…The finding that some well-established IBD therapeutics do not have any effect in the model highlights important differences between the experimental model and the human disease.…”
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Massively Parallel Sequencing of a Chinese Family with DFNA9 Identified a Novel Missense Mutation in the LCCL Domain of COCH by Xiaodong Gu, Wenling Su, Mingliang Tang, Luo Guo, Liping Zhao, Huawei Li

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Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. by Tonibelle Gatbonton, Maria Imbesi, Melisa Nelson, Joshua M Akey, Douglas M Ruderfer, Leonid Kruglyak, Julian A Simon, Antonio Bedalov

“…Furthermore, our results laid the foundation for studying genetic determinants of telomere length-variation and their roles in human disease.…”
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EVALUATION OF ASSISTANCE TOOLS FOR DIAGNOSIS OF DISEASES BY APPROACHING TO PERSONALIZED MEDICINE ON METAGENOMIC DATA by Phan Tấn Tài, Tạ Đặng Vĩnh Phúc, Phan Nguyễn Minh Thảo, Nguyễn Thị Ngọc Chăm, Đào Công Tính, Phạm Huỳnh Ngọc, Nguyễn Thanh Hải

“…Within the scope of this research, we introduce and evaluate useful tools for studying Metagenomic data in supporting the diagnosis of human disease and health conditions. From these studies, we may develop extensive and in-depth studies from previous studies to explore the important effect of the microbial ecosystem that is a rich set of microbial features for prediction and biomarker discovery in the human body. …”
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Keratitis due to Chaetomium sp. by Jayaraman Kaliamurthy, Catti Munuswamy Kalavathy, Christadoss Arul Nelson Jesudasan, Philip A. Thomas

“…Fungi of the genus Chaetomium, which are rare causes of human disease (systemic mycosis, endocarditis, subcutaneous lesions), may also cause ocular lesions.…”
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Translating time: Challenges, progress, and future directions by Christine J. Charvet, Alexandra A. de Sousa, Tatianna Vassilopoulos

“…Accordingly, the relevance of studying mice to understand human disease is limited. We discuss examples associated with limitations of the mouse model, and how the inclusion of a richer array of model systems can help address long standing issues in biomedical sciences. …”
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Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

“…Thus, it is unsurprising that alteration of protein acetylation is involved in human disease, including metabolic disorders and cancers. …”
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