Aging in Persons with Rett Syndrome: An Updated Review by Meir Lotan, Joav Merrick, Isack Kandel, Mohammed Morad

“…Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. …”
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Brazilian Spotted Fever with an Approach in Veterinary Medicine and One Health Perspective by Sabrina Destri Emmerick Campos, Nathalie Costa da Cunha, Nádia Regina Pereira Almosny

“…Dogs have been considered sentinels, and in some areas the disease in dogs can precede human disease. Considering the importance of this disease for human health, the serological evidence in dogs, and the transmission of ticks between dogs and their owners, this review aimed to elucidate the importance of the epidemiological investigation, the diagnosis in dogs, and the role of veterinarians in Public Health to control vector-borne zoonotic diseases. …”
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Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells by Rickie Patani

“…These studies will in turn permit greater mechanistic understanding of differential MN subtype vulnerability using in vitro human disease models.…”
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Histocompatibility and Hematopoietic Transplantation in the Zebrafish by Jill L. O. de Jong, Leonard I. Zon

“…The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. …”
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Synonymous Codon Usage Controls Various Molecular Aspects by Eu-Hyun Im, Sun Shim Choi

“…For instance, a recent study demonstrated that synonymous single nucleotide polymorphisms have a similar effect size as nonsynonymous single nucleotide polymorphisms in human disease association studies. Researchers have recognized synonymous codon usage bias (SCUB) in the genomes of almost all species and have investigated whether SCUB is due to random nucleotide compositional bias or to natural selection of any functional exposure generated by synonymous mutations. …”
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Plucked Human Hair Shafts and Biomolecular Medical Research by Kevin Schembri, Christian Scerri, Duncan Ayers

“…Consequently, the use of noninvasive diagnostic procedures on hair follicle shafts, posing as a surrogate molecular model for internal organs in the individual patient for a spectrum of human disease conditions, can possibly become a reality in the near future.…”
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Leukocyte migration in experimental inflammatory bowel disease by E. P. Van Rees, M. J. H. J. Palmen, F. R. W. Van De Goot, B. A. Macher, L. A. Dieleman

“…The importance of each of these groups of adhesion molecules in chronic inflammatory bowel disease, either in human disease or in animal models, will be discussed below. …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Growing evidence points to a role of aberrant DSB physiology in human disease and an understanding of these processes may both inform the design of new therapeutic strategies and reduce off-target effects of existing drugs. …”
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Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells by Gregory M. Kelly, Mohamed I. Gatie

“…Another major focus is on the epigenetic regulation of ECCs and stem cells, and, towards that end, this review closes on what we see as a new frontier in combating aging and human disease, namely, how cellular metabolism shapes the epigenetic landscape and hence the pluripotency of all stem cells.…”
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Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips by Thilo Hagen

“…Hypoxia inducible factor (HIF) is known as the master regulator of the cellular response to hypoxia and is of pivotal importance during development as well as in human disease, particularly in cancer. It is composed of a constitutively expressed β subunit (HIF-1β) and an oxygen-regulated α subunit (HIF-1α and HIF-2α), whose stability is tightly controlled by a family of oxygen- and iron-dependent prolyl hydroxylase enzymes. …”
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TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit.…”
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Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD by Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer

“…Some conservation exists between alternative polyadenylation in rNLS8 mice and human disease models including in disease relevant genes and biological pathways. …”
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TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling by Rambon Shamilov, Brian J. Aneskievich

“…Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis. …”
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Unusual Methylobacterium fujisawaense Infection in a Patient with Acute Leukaemia Undergoing Hematopoietic Stem Cell Transplantation: First Case Report by Rosa Fanci, Giampaolo Corti, Alessandro Bartoloni, Enrico Tortoli, Alessandro Mariottini, Patrizia Pecile

“…Microorganisms of the genus Methylobacterium are facultative methylotrophic, gram-negative rods that are ubiquitous in nature and rarely cause human disease, mostly in subjects with preexisting causes of immune depression. …”
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Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…Experimental models that mimic human disease have been developed in order to study pathogenic and therapeutic mechanisms, but have shown mixed success in clinical application. …”
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Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis? by U. R. Goonetilleke, S. A. Ward, S. B. Gordon

“…The contribution of these pathways to human disease is unknown. Using proteomic techniques, neuronal death pathways could be described in CSF samples. …”
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The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases by César Pacheco-Tena, Susana Aideé González-Chávez

“…Both roles are not mutually exclusive. Some examples in human disease and in animal models are provided based on current evidence.…”
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RETRACTED: Biodiversity Loss with Habitat and Risk of New Diseases by Darshit Ram

“…The maintenance of biodiversity is hypothesised to reduce pathogen prevalence and consequently human disease risk through the dilution effect. However, assuming microbial diversity correlates with that of all other life forms, there may be increased potential for novel pathogens to emerge from biodiverse regions. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Furthermore, iPS cell technology has generated new human disease models using disease-specific cells. This paper summarizes the progress of iPS cell technology in cardiovascular research.…”
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Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Epigenetic mechanisms play a role in human disease but their involvement in pathologies from the central nervous system has been hampered by the complexity of the brain together with its unique cellular architecture and diversity. …”
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