Preventing Foodborne Illness: Bacillus cereus and Bacillus anthracis by Keith R. Schneider, Mickey E. Parish, Renée M. Goodrich, Taylor Cookingham

“…There are about 48 known species in the genus Bacillus but only B. anthracis and B. cereus are associated with human disease. Bacillus species are mesophilic bacteria that produce heat-resistant endosopores with a growth range of 10°C to 48°C, with optimal growth at 28°C to 35°C. …”
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The Biological and Metabolic Fates of Endogenous DNA Damage Products by Simon Wan Chan, Peter C. Dedon

“…These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways. …”
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Super-resolution microscopy as a drug discovery tool by Lauren Toms, Lorna FitzPatrick, Philip Auckland

“…Now, after nearly two decades, super-resolution microscopy has begun to address previously unmet challenges in the study of human disease and is poised to become a pivotal tool in drug discovery.…”
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Preventing Foodborne Illness: Bacillus cereus and Bacillus anthracis by Keith R. Schneider, Mickey E. Parish, Renée M. Goodrich, Taylor Cookingham

“…There are about 48 known species in the genus Bacillus but only B. anthracis and B. cereus are associated with human disease. Bacillus species are mesophilic bacteria that produce heat-resistant endosopores with a growth range of 10°C to 48°C, with optimal growth at 28°C to 35°C. …”
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A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice. by Rebekah L Bullard, Mercedes Cheslock, Shiva Kumar Goud Gadila, Ricardo G Maggi, Edward B Breitschwerdt, Ahmad A Saied, Monica E Embers

“…For this study, Bartonella henselae, the most common species associated with human disease, was injected into Swiss Webster (SW) mice. …”
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Atherogenic Factors and Their Epigenetic Relationships by Ana Z. Fernandez, Andrew L. Siebel, Assam El-Osta

“…However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. …”
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Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation by Yong Yi, Guoqiang Wang, Wenhua Zhang, Shuhan Yu, Junjie Fei, Tingting An, Jianqiao Yi, Fengtian Li, Ting Huang, Jian Yang, Mengmeng Niu, Yang Wang, Chuan Xu, Zhi-Xiong Jim Xiao

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The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner by Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Anzu Matsumura, Daisuke Miyashita, Kuniyuki Nishiyama, Yusuke Takano, Yu Togashi, Makiko Meguro-Horike, Shin-ichi Horike, Tatsuya Kin, A.M. James Shapiro, Hiromi Yanagisawa, Yasuo Terauchi, Jun Shirakawa

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Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation by Xiaoling Lu, Yilai Shu, Mingliang Tang, Huawei Li

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Aging in Persons with Rett Syndrome: An Updated Review by Meir Lotan, Joav Merrick, Isack Kandel, Mohammed Morad

“…Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. …”
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Brazilian Spotted Fever with an Approach in Veterinary Medicine and One Health Perspective by Sabrina Destri Emmerick Campos, Nathalie Costa da Cunha, Nádia Regina Pereira Almosny

“…Dogs have been considered sentinels, and in some areas the disease in dogs can precede human disease. Considering the importance of this disease for human health, the serological evidence in dogs, and the transmission of ticks between dogs and their owners, this review aimed to elucidate the importance of the epidemiological investigation, the diagnosis in dogs, and the role of veterinarians in Public Health to control vector-borne zoonotic diseases. …”
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Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells by Rickie Patani

“…These studies will in turn permit greater mechanistic understanding of differential MN subtype vulnerability using in vitro human disease models.…”
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Histocompatibility and Hematopoietic Transplantation in the Zebrafish by Jill L. O. de Jong, Leonard I. Zon

“…The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. …”
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Synonymous Codon Usage Controls Various Molecular Aspects by Eu-Hyun Im, Sun Shim Choi

“…For instance, a recent study demonstrated that synonymous single nucleotide polymorphisms have a similar effect size as nonsynonymous single nucleotide polymorphisms in human disease association studies. Researchers have recognized synonymous codon usage bias (SCUB) in the genomes of almost all species and have investigated whether SCUB is due to random nucleotide compositional bias or to natural selection of any functional exposure generated by synonymous mutations. …”
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Plucked Human Hair Shafts and Biomolecular Medical Research by Kevin Schembri, Christian Scerri, Duncan Ayers

“…Consequently, the use of noninvasive diagnostic procedures on hair follicle shafts, posing as a surrogate molecular model for internal organs in the individual patient for a spectrum of human disease conditions, can possibly become a reality in the near future.…”
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Leukocyte migration in experimental inflammatory bowel disease by E. P. Van Rees, M. J. H. J. Palmen, F. R. W. Van De Goot, B. A. Macher, L. A. Dieleman

“…The importance of each of these groups of adhesion molecules in chronic inflammatory bowel disease, either in human disease or in animal models, will be discussed below. …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Growing evidence points to a role of aberrant DSB physiology in human disease and an understanding of these processes may both inform the design of new therapeutic strategies and reduce off-target effects of existing drugs. …”
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Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells by Gregory M. Kelly, Mohamed I. Gatie

“…Another major focus is on the epigenetic regulation of ECCs and stem cells, and, towards that end, this review closes on what we see as a new frontier in combating aging and human disease, namely, how cellular metabolism shapes the epigenetic landscape and hence the pluripotency of all stem cells.…”
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Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips by Thilo Hagen

“…Hypoxia inducible factor (HIF) is known as the master regulator of the cellular response to hypoxia and is of pivotal importance during development as well as in human disease, particularly in cancer. It is composed of a constitutively expressed β subunit (HIF-1β) and an oxygen-regulated α subunit (HIF-1α and HIF-2α), whose stability is tightly controlled by a family of oxygen- and iron-dependent prolyl hydroxylase enzymes. …”
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Near-Infrared Fluorescent Digital Pathology for the Automation of Disease Diagnosis and Biomarker Assessment by Summer L. Gibbs, Elizabeth Genega, Jeffery Salemi, Vida Kianzad, Haley L. Goodwill, Yang Xie, Rafiou Oketokoun, Parmeshwar Khurd, Ali Kamen, John V. Frangioni

“…In this study, we demonstrate that diagnostic information provided by two or more independent wavelengths of near-infrared (NIR) fluorescence leave the H&E stain unchanged while enabling computer-assisted diagnosis and assessment of human disease. Using prostate cancer as a model system, we introduce NIR digital pathology and demonstrate its utility along the spectrum from prostate biopsy to whole mount analysis of H&E-stained tissue.…”
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