Effects of sex, mating status, and genetic background on circadian behavior in Drosophila by Oghenerukevwe Akpoghiran, Alexandra K. Strich, Kyunghee Koh

“…This study advances our understanding of how sex and mating influence circadian rhythms in Drosophila and provides a foundation for future research into sexually dimorphic mechanisms underlying human diseases associated with circadian disruptions.…”
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Herb-disease association prediction model based on network consistency projection by Lei Chen, Shiyi Zhang, Bo Zhou

“…Abstract A growing number of biological and clinical reports indicate the usefulness of herbs in the treatment of complex human diseases, giving an essential supplement for modern medicine. …”
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Graph Convolutional Network with Neural Collaborative Filtering for Predicting miRNA-Disease Association by Jihwan Ha

“…Therefore, much effort has been devoted to discovering the pivotal roles of miRNAs in disease incidence to understand the underlying pathogenesis of human diseases. However, identifying miRNA–disease associations using biological experiments is inefficient in terms of cost and time. …”
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Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model by Ibrahim Maina Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Binti Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…Reactive oxygen species generation in mammalian cells profoundly affects several critical cellular functions, and the lack of efficient cellular detoxification mechanisms which remove these radicals may lead to several human diseases. Several studies show that ROS is incriminated as destructive agents in the context of the nervous system especially with advance in age leading to neurodegeneration. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. …”
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Chromosome 1 Sequence Analysis of C57BL/6J-Chr1KM Mouse Strain by Fuyi Xu, Tianzhu Chao, Yiyin Zhang, Shixian Hu, Yuxun Zhou, Hongyan Xu, Junhua Xiao, Kai Li

“…Further functional annotation identified 155 genes harboring potentially functional variants, among which 27 genes have been associated with human diseases. We then performed sequence similarity and Bayesian concordance analysis using the SNPs identified on Chr 1 and their counterparts in three subspecies, Mus musculus domesticus, M. m. musculus, and M. m. castaneus. …”
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Ozone oxidative preconditioning: a protection against cellular damage by free radicals by O. S. León, S. Menéndez, N. Merino, R. Castillo, S. Sam, L. Pérez, E. Cruz, V. Bocci

“…There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases . However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. …”
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Protein Ubiquitylation in Pancreatic Cancer by Thomas Bonacci, Julie Roignot, Philippe Soubeyran

“…Whereas it has been known for more than 3 decades now, ubiquitylation is a post-translational modification of protein that only recently emerged as a major regulator of many biological functions, dependent and independent on the proteasome, whose failure is involved in many human diseases, including cancer. Indeed, despite its role in promoting protein degradation through the proteasome, ubiquitylation is now known to regulate diverse cellular processes, such as membrane protein endocytosis and intracellular trafficking, assembly of protein complexes, gene transcription, and activation or inactivation of enzymes. …”
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Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes by Sungkyoung Choi, Sunghwan Bae, Taesung Park

“…However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. …”
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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years by Frank Tacke, Martina E. Spehlmann, Mihael Vucur, Fabian Benz, Mark Luedde, David Vargas Cardenas, Sanchari Roy, Sven Loosen, Hans-Joerg Hippe, Norbert Frey, Christian Trautwein, Alexander Koch, Christoph Roderburg, Tom Luedde

“…Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.…”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Mutations in RECQL4 have been associated with various human diseases, including Rothmund–Thomson syndrome. RECQL4 is involved in regulating major DNA repair pathways, such as homologous recombination and nonhomologous end joining (NHEJ). …”
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Anal Sphincter Function After Hemorrhoidectomy by A. M. Kuzminov, O. Yu. Fomenko, I. A. Mukhin, S. A. Frolov, D. V. Vyshegorodtsev, V. Yu. Korolik, S. T. Minbaev, S. V. Belousova

“…The haemorrhoid disease is one of the most common human diseases and the most common reason for visiting a coloproctologist. …”
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Brain metabolites in ISIAH and Wistar rats by O. B. Shevelev, A. A. Seryapina, A. L. Markel, M. P. Moshkin

“…Hypertension is one of the most common human diseases. This disease leads to serious disturbances such as myocardial infarction and stroke. …”
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miR-203 Expression in Exfoliated Cells of Tongue Coating Represents a Sensitive and Specific Biomarker of Gastroesophageal Reflux Disease by Xiuli Yan, Shengliang Zhu, Hui Zhang

“…MicroRNAs (miRNAs) have been implicated in the pathophysiology of numerous human diseases including gastroesophageal reflux disease (GERD). …”
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Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples by Marta Sosnowska, Tomasz Łęga, Marcin Olszewski, Beata Gromadzka

“…Among the numerous harmful metal ions, copper ions are responsible for a variety of human diseases. Results This study investigates the application of phage display as a screening method for heavy metal toxicological targets, with copper served as the main focus. …”
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General Approach to Identifying Potential Targets for Cancer Imaging by Integrated Bioinformatics Analysis of Publicly Available Genomic Profiles by Yongliang Yang, S. James Adelstein, Amin I. Kassis

“…This systematic mining approach can be broadly applied to identify imaging or therapeutic targets for other human diseases.…”
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…In recent years, this dichotomic stress response system has been linked to several human diseases, and efforts are underway to develop approaches to exploit ER stress mechanisms for therapy. …”
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Determination of the levels of some selected metals in ocimum lamiifolium in Wolaita Zone, Southern Ethiopia by Eyob Yishak, Teferi Tademe Dadebo

“… Medicinal plants have worldwide applications in the treatment of different types of human diseases. Among the medicinal plants of Ethiopia, Ocimum lamiifolium Hochst. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…The ability to create patient-specifc pluripotent cells and their subsequent differentiation into any somatic cell type makes hiPS cells a valuable object for creating in vitro models of human diseases, screening drugs and a future source of cells for regenerative medicine. …”
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Determination of the levels of some selected metals in ocimum lamiifolium in Wolaita Zone, Southern Ethiopia by Eyob Yishak, Teferi Tademe Dadebo

“… Medicinal plants have worldwide applications in the treatment of different types of human diseases. Among the medicinal plants of Ethiopia, Ocimum lamiifolium Hochst. …”
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