Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. by Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen

“…Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers. Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transducer. …”
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Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Yoshikazu Nakaoka, Issei Komuro

“…In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders. …”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. …”
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Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy by Casimir de Rham, Jean Villard

“…Tissues or organs derived from hPS cells could be the best solution to cure many different human diseases, especially those who do not respond to standard medication or drugs, such as neurodegenerative diseases, heart failure, or diabetes. …”
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N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…Their influence on the synthesis and processing of messenger RNA, ribosomal RNA, and transfer RNA allows m7G modifications to affect diverse cellular, physiological, and pathological processes. m7G modifications are pivotal in human diseases, particularly cancer progression. On one hand, m7G modification-associated modulate tumour progression and affect malignant biological characteristics, including sustained proliferation signalling, resistance to cell death, activation of invasion and metastasis, reprogramming of energy metabolism, genome instability, and immune evasion. …”
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Sensitive and label-free fluorescent microRNA detection via catalytic DNAzyme assembly initiated primer exchange reaction by Heng Wang, Yi Sun

“…MicroRNAs (miRNAs) have an intricate connection to the development of human diseases, such as malignancies, diabetes, and viral infections; therefore, their rapid and precise identification is critical in disease diagnosis and treatment. …”
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Lipid Peroxidation and Antioxidant Activities of the Aqueous Rhizome Extract of Rheum officinale Baillon by Eugene Chang, Choon Young Kim

“…Generation of reactive oxygen species (ROS) is associated with dysregulation of antioxidant defense mechanisms and incidence of human diseases. The specific aim of this study was to investigate the lipid oxidation and antioxidant activity of aqueous extract of Rheum officinale Baillon rhizome in order to evaluate its potential as a future novel natural antioxidant resource and a functional ingredient in food and pharmaceutical formations. …”
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Coccoloba uvifera (L.) (Polygonaceae) Fruit: Phytochemical Screening and Potential Antioxidant Activity by Maira Rubi Segura Campos, Jorge Ruiz Ruiz, Luis Chel-Guerrero, David Betancur Ancona

“…Antioxidant compounds are now of considerable interest due to their effect of preventing or delaying aging and their apparent involvement in prevention of numerous human diseases, including cancer, atherosclerosis, Alzheimer’s disease, inflammation, and rheumatoid arthritis. …”
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Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence by ZHENG Qingyong, LI Tengfei, XU Jianguo, ZHOU Yongjia, MA Zhichao, WANG Na, LI Molan, YANG Wenjing, WU Peirun, WANG Haidong, TIAN Jinhui

“…Animal models have played an irreplaceable role in simulating human diseases. However, the integration of evidence from animal experiments has faced numerous challenges, including insufficient emphasis, significant heterogeneity in study designs, high publication bias, and discrepancies with clinical research practices. …”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. …”
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AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis by Valentina Saverio, Emanuele Ferrario, Romina Monzani, Mara Gagliardi, Francesco Favero, Davide Corà, Claudio Santoro, Marco Corazzari

“…Conversely, dysregulated iron metabolism and alterations in the expression or activity of key anti-ferroptotic components are linked to the development and progression of various human diseases, including multiple sclerosis (MS). In MS, the improper activation of ferroptosis has been associated with the progressive loss of myelinating oligodendrocytes (myOLs). …”
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Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single‐Molecule Conductance by Lihua Zhao, Yang Xu, Zhiheng Yang, Wenzhe Liu, Shichao Zhong, Jingwei Bai, Xuefeng Guo

“…Although the function and (de)regulation of Pols are linked to many human diseases, the key mechanism of 3′‐OH deprotonation and the PPi formation are not totally clear. …”
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Comprehensive analysis of advanced glycation end-products in commonly consumed foods: presenting a database for dietary AGEs and associated exposure assessment by Qiaozhi Zhang, Huatao Li, Ruixing Zheng, Lili Cao, Shufen Zhang, Shuifeng Zhang, Huadong Sheng, Yuhao Jiang, Yanbo Wang, Linglin Fu

“…Currently, there is no comprehensive database for AGEs in foods that covers the entire range of food categories, which limits the accurate risk assessment of dietary AGEs in human diseases. In this study, we first established an isotope dilution UHPLC-QqQ-MS/MS-based method for simultaneous quantification of 10 major AGEs in foods. …”
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PLncWX: A Machine-Learning Algorithm for Plant lncRNA Identification Based on WOA-XGBoost by Fei Guo, Zhixiang Yin, Kai Zhou, Jiasi Li

“…Studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels, which are not only closely related to the occurrence, development, and prevention of human diseases, but also can regulate plant flowering and participate in plant abiotic stress responses such as drought and salt. …”
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Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas. by Victoria E S Armero, Marie-Pier Tremblay, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Cyntia Duval, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Martin Bisaillon

“…Multiple human diseases including cancer have been associated with a dysregulation in RNA splicing patterns. …”
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Targeting the epigenome with advanced delivery strategies for epigenetic modulators by Sonia Guha, Yogeswaran Jagadeesan, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara

“…Abstract Epigenetics mechanisms play a significant role in human diseases by altering DNA methylation status, chromatin structure, and/or modifying histone proteins. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…Many PPARγ ligands are under investigation as potential therapies for human diseases. These ligands modulate multiple cellular pathways via both PPARγ-dependent and PPARγ-independent mechanisms. …”
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An unstable variant of GAP43 leads to neurodevelopmental deficiency by Mariko Noda, Ayumi Matsumoto, Hidenori Ito, Masayo Kagami, Toshihiro Tajima, Takayoshi Matsumura, Takanori Yamagata, Koh-ichi Nagata

“…Our study will contribute to a better understanding of how dysregulation of GAP43 leads to human diseases.…”
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Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17 by Fenglei Jian, Shen Wang, Wenmin Tian, Yang Chen, Shixuan Wang, Yan Li, Cong Ma, Yueguang Rong

“…Abstract Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. …”
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HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses. by Jiwon Yu, Junha Cha, Geon Koh, Insuk Lee

“…These findings suggest that HCNetlas has the potential to link disease-associated genes to cell types of action, facilitating development of cell type-resolved diagnostics and therapeutic strategies for complex human diseases.…”
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