Prediction of Quantitative Traits Using Common Genetic Variants: Application to Body Mass Index by Sunghwan Bae, Sungkyoung Choi, Sung Min Kim, Taesung Park

“…With the success of the genome-wide association studies (GWASs), many candidate loci for complex human diseases have been reported in the GWAS catalog. …”
Get full text

RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

“…In addition, an emphasis has been placed on the clinical role of targeting aberrant splicing corrections in human diseases. The principal mechanisms of action behind this phenomenon are described, followed by a discussion of prospective development strategies and pertinent challenges.…”
Get full text

The Promise of Human Induced Pluripotent Stem Cells in Dental Research by Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim, Vijayendran Govindasamy

“…In this paper, we will summarize the recent progress of the disease-specific iPSC development for various human diseases and try to evaluate the possibility of application of iPS technology in dentistry, including its capacity for reprogramming some genetic orodental diseases. …”
Get full text

Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis by Lopamudra Roy, Shweta Paul, Amrita Banerjee, Ria Ghosh, Susmita Mondal, Monojit Das, Monojit Das, Nivedita Pan, Ishitri Das, Soumendra Singh, Debasish Bhattacharya, Asim Kumar Mallick, Samir Kumar Pal

“…Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. …”
Get full text

Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management by Adil Hassan, Yin Huang, Mahjabina, Otmilda Hapsari Sudiro, Xiangxiu Wang, Jingqin He, Yan Wei, Xiaoling Liao, Guixue Wang

“…Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. …”
Get full text

Near-Infrared Imaging of Injured Tissue in Living Subjects Using IR-820 by Suresh I. Prajapati, Carlo O. Martinez, Ali N. Bahadur, Isabel Q. Wu, Wei Zheng, James D. Lechleiter, Linda M. McManus, Gary B. Chisholm, Joel E. Michalek, Paula K. Shireman, Charles Keller

“…This novel contrast agent is anticipated to be a useful and an inexpensive tool for screening a wide variety of preclinical models of human diseases.…”
Get full text

Computational Insights in DNA Methylation: Catalytic and Mechanistic Elucidations for Forming 3-Methyl Cytosine by Mansour H. Almatarneh, Ghada G. Kayed, Mohammednoor Altarawneh, Yuming Zhao, Amita Verma

“…Methylation at C5 position of cytosine (5 mC) is the most abundantly occurring methylation process at CpG island, which has been well known as an epigenetic modification linked to many human diseases. Recently, another methylation approach has been discovered to show that DNA methyltransferases (DNMTs) promote the addition of the methyl group at position 3 to yield 3 mC. …”
Get full text

EFFECT OF ELEVATED TEMPERATURE ON THE SURVIVAL OF DROSOPHILA MELANOGASTER INFECTED WITH A PATHOGENIC WOLBACHIA STRAIN by A. A. Strunov, Yu. Yu. Ilinskii, I. K. Zakharov, E. V. Kiseleva

“…This fact makes it promising for control of insect pests and transmitters of human diseases. Any symbiotic association is exposed to various stress factors: starvation, heat, cold, etc., which affect the symbiont interaction significantly. …”
Get full text

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

“…Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. …”
Get full text

Optogenetic control of mitochondrial aggregation and function by Luhao Zhang, Luhao Zhang, Luhao Zhang, Xuechun Liu, Min Zhu, Min Zhu, Yuanfa Yao, Zhichao Liu, Xianming Zhang, Xin Deng, Yi Wang, Liting Duan, Xiaogang Guo, Junfen Fu, Yingke Xu, Yingke Xu, Yingke Xu

“…Abnormal mitochondrial fission and fragmentation have been shown to be associated with oxidative stress, which causes a variety of human diseases from neurodegeneration disease to cancer. …”
Get full text

High Sensitivity Method to Estimate Distribution of Hyaluronan Molecular Sizes in Small Biological Samples Using Gas-Phase Electrophoretic Mobility Molecular Analysis by Lan Do, Christen P. Dahl, Susanne Kerje, Peter Hansell, Stellan Mörner, Ulla Lindqvist, Anna Engström-Laurent, Göran Larsson, Urban Hellman

“…Difficulty to obtain large enough biopsies from human diseased tissue or tissue from animal models has also restricted the study of hyaluronan. …”
Get full text

miR-155: An Important Role in Inflammation Response by Jingyan Hu, Songli Huang, Xiaoli Liu, Yuan Zhang, Shengli Wei, Xiuhua Hu

“…The widespread involvement of miR-155 in human diseases has led to a novel therapeutic approach between Chinese and Western medicine.…”
Get full text

Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney by Sergio Veloso Brant Pinheiro, Ana Cristina Simões e Silva

“…In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced. …”
Get full text

Network-Based Protein Biomarker Discovery Platforms by Minhyung Kim, Daehee Hwang

“…The advances in mass spectrometry-based proteomics technologies have enabled the generation of global proteome data from tissue or body fluid samples collected from a broad spectrum of human diseases. Comparative proteomic analysis of global proteome data identifies and prioritizes the proteins showing altered abundances, called differentially expressed proteins (DEPs), in disease samples, compared to control samples. …”
Get full text

Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

Get full text

The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Altered MMP/TIMP ratios are frequently observed in several human diseases. During aging and disease progression, the extracellular matrix (ECM) undergoes structural changes in which elastin and collagens serve an essential role. …”
Get full text

A multiscale model of the bone marrow and hematopoiesis by Ariosto Silva, Alexander R. A. Anderson, Robert Gatenby

“…The bone marrow is necessary for renewal of all hematopoietic cells and critical for maintenance of a wide range of physiologic functions. Multiple human diseases result from bone marrow dysfunction. It is also the site in which liquid tumors, including leukemia and multiple myeloma, develop as well as a frequent site of metastases. …”
Get full text

Antigenic Complementarity in the Origins of Autoimmunity: A General Theory Illustrated With a Case Study of Idiopathic Thrombocytopenia Purpura by Robert Root-Bernstein, Jacob Couturier

“…Data demonstrating that complementary antigens are found in some animal models of autoimmunity and may be present in various human diseases, especially ITP, are reviewed. Specific mechanisms for preventing autoimmunity or suppressing existing autoimmunity are derived from the theory, and critical tests proposed. …”
Get full text

The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. …”
Get full text

Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer by Perumal Elumalai, Jagadeesan Arunakaran

“…Nimbolide, a limnoid derived from the neem (Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various human diseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. …”
Get full text