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  1. 221
  2. 222

    Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma by Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp

    Published 2021-01-01
    “…The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known to be related to human diseases. Systemic sequelae of MSD are vast and multisystemic, primarily encompassing developmental delay and neurological, cardiopulmonary, dermatological, gastroenterological, and skeletal manifestations. …”
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  3. 223

    Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals by Wei Mao, Xingnan Ge, Qianping Chen, Jia-Da Li

    Published 2025-01-01
    “…Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. …”
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  4. 224

    Extraction of Keratin degrading enzyme from marine Actinobacteria of Nocardia sp and their antibacterial potential against oral pathogens by Haripriya Arun Subash, K. Santhosh, Kamala Kannan, Sivaperumal Pitchiah

    Published 2024-03-01
    “…The organism is known to withstand extreme temperatures and pH levels, with some strains being associated with marine organisms, while others are implicated in human diseases. Additionally, it synthesizes enzymes of biotechnological importance. …”
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  5. 225
  6. 226

    Pathogenicity of Virulent Species of Group C Streptococci in Human by Marta Kłos, Jadwiga Wójkowska-Mach

    Published 2017-01-01
    “…This report focuses mainly on the pathogenicity of virulent species of GCS and their association with human diseases. The condition that is most frequently quoted is pharyngitis. …”
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  7. 227

    Alternative Cell Death Pathways and Cell Metabolism by Simone Fulda

    Published 2013-01-01
    “…A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.…”
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  8. 228

    Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation by Tong Wang, Zhongwen Xing, Dingyu Xing

    Published 2013-01-01
    “…Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria.…”
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  9. 229

    Cancer, Natural Products and Nanodrug Delivery Systems by Yong Sze Ong, Loh Teng-Hern Tan

    Published 2020-06-01
    “…One of the promising breakthroughs is the application of natural product-based nanoformulations for the treatment of various human diseases, such as cancer. Principally, the nanoparticle-based drug delivery system (NDDS) aims to overcome the limitations of conventional drug delivery system. …”
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  10. 230

    EPA’s Endocrine Disruptor Screening Program (EDSP) by Frederick M. Fishel

    Published 2013-03-01
    “…The relationship between human diseases of the endocrine system and exposure to environmental contaminants is poorly understood and controversial. …”
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  11. 231

    EPA’s Endocrine Disruptor Screening Program (EDSP) by Frederick M. Fishel

    Published 2013-03-01
    “…The relationship between human diseases of the endocrine system and exposure to environmental contaminants is poorly understood and controversial. …”
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  12. 232

    ISOLATION AND STRUCTURAL CHARACTERIZATION OF TWO SAPONINS FROM THE ROOTS OF Sansevieria trifasciata ‘Laurentii’ by Duc Hung Nguyen, Quang Tan Tu, Hoang Mau Chu

    Published 2023-06-01
    “…Many Sansevieria species are used for ornamental purposes or in traditional medicine to treat human diseases. Sansevieria trifasciata ‘Laurentii,’ commonly known as snake plant, is an evergreen perennial plant used in traditional medicine. …”
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  13. 233

    Multidimensional library for the improved identification of per- and polyfluoroalkyl substances (PFAS) by Kara M. Joseph, Anna K. Boatman, James N. Dodds, Kaylie I. Kirkwood-Donelson, Jack P. Ryan, Jian Zhang, Paul A. Thiessen, Evan E. Bolton, Alan Valdiviezo, Yelena Sapozhnikova, Ivan Rusyn, Emma L. Schymanski, Erin S. Baker

    Published 2025-01-01
    “…Abstract As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages to chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). …”
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  14. 234

    PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance by Vladimir T. Todorov

    Published 2013-01-01
    “…Furthermore, I discuss the need for generating of additional transgenic animal models which are more appropriate with regard to the role of the PPARgamma-dependent regulation of the renin gene expression in human diseases such as arterial hypertension and metabolic syndrome.…”
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  15. 235

    Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases by Jinli Li, Yang Li, Guangtao Song, Haiying Wang, Qing Zhang, Min Wang, Muxue Zhao, Bei Wang, HuiGuo Zhu, Liu Ranzhi, Qiang Wang, Yuyan Xiong

    Published 2025-02-01
    “…This groundbreaking technology offers a unique opportunity to study human diseases and address the limitations of traditional animal models. …”
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  16. 236

    The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases by Keshav Raj Sigdel, Ao Cheng, Yin Wang, Lihua Duan, YanLin Zhang

    Published 2015-01-01
    “…The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. …”
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  17. 237

    Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

    Published 2025-01-01
    “…This cost-effective approach, akin to the setup of traditional 1D or 2D dPCR, holds the potential to advance the application of rAAV in cell and gene therapy for the treatment of human diseases.…”
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  18. 238

    Challenges in classifying human chromosomal heteromorphisms using banding cytogenetics: From controversial guidelines to the need for a universal scoring system by Sílvia Pires, Paula Jorge, Thomas Liehr, Natália Oliva-Teles

    Published 2024-10-01
    “…Nonetheless, their clinical importance is increasingly under scrutiny, with several studies aiming to assess their influence on human diseases and susceptibilities, especially as they are seemingly part of the long noncoding RNAs in certain tissues. …”
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  19. 239

    Aspergillus-Related Lung Disease by Alia Al-Alawi, C Frank Ryan, Julia D Flint, Nestor L Müller

    Published 2005-01-01
    “…Aspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases ranging in severity from trivial to life-threatening, depending on the host response. …”
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  20. 240

    MAP: Mutation Arranger for Defining Phenotype-Related Single-Nucleotide Variant by In-Pyo Baek, Yong-Bok Jeong, Seung-Hyun Jung, Yeun-Jun Chung

    Published 2014-12-01
    “…Next-generation sequencing (NGS) is widely used to identify the causative mutations underlying diverse human diseases, including cancers, which can be useful for discovering the diagnostic and therapeutic targets. …”
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