Antigenic Complementarity in the Origins of Autoimmunity: A General Theory Illustrated With a Case Study of Idiopathic Thrombocytopenia Purpura by Robert Root-Bernstein, Jacob Couturier

“…Data demonstrating that complementary antigens are found in some animal models of autoimmunity and may be present in various human diseases, especially ITP, are reviewed. Specific mechanisms for preventing autoimmunity or suppressing existing autoimmunity are derived from the theory, and critical tests proposed. …”
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The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. …”
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Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer by Perumal Elumalai, Jagadeesan Arunakaran

“…Nimbolide, a limnoid derived from the neem (Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various human diseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. …”
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Causality-driven candidate identification for reliable DNA methylation biomarker discovery by Xinlu Tang, Rui Guo, Zhanfeng Mo, Wenli Fu, Xiaohua Qian

“…The comprehensive reliability of the proposed method was verified by simulations and applications involving various human diseases, sample origins, and sequencing technologies, highlighting its universal biomedical significance. …”
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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo by Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis

“…Dysregulation of TFEB is associated with a range of human diseases, and understanding the regulatory mechanisms of TFEB is crucial for identifying potential drug targets. …”
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Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules by Yan-Chuang Han, Yoon Lim, Michael D. Duffieldl, Hua Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Miao Yang, Damien J. Keating, Xin-Fu Zhou

“…Although it is possible to generate neural stem cells (NSC) from somatic cells by reprogramming technologies with transcription factors, clinical utilization of patient-specific NSC for the treatment of human diseases remains elusive. The risk hurdles are associated with viral transduction vectors induced mutagenesis, tumor formation from undifferentiated stem cells, and transcription factors-induced genomic instability. …”
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Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application by Qian Zhu, Qiqi Lu, Rong Gao, Tong Cao

“…NCSC maldevelopment is related to various human diseases including pigmentation abnormalities, disorders affecting autonomic nervous system, and malformations of teeth, eyes, and hearts. …”
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SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis by Mario Saare, Uku Hämarik, Rainis Venta, Marina Panarina, Chiara Zucchelli, Maire Pihlap, Anu Remm, Kai Kisand, Urve Toots, Kaidi Möll, Riina Salupere, Giovanna Musco, Raivo Uibo, Pärt Peterson

“…The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases. Here, we have characterized the SP100 family member SP140L. …”
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Human Gut Microbes Associated with Systolic Blood Pressure by Tulsi Kumari Joishy, Aashish Jha, Mai Oudah, Santanu Das, Atanu Adak, Dibyayan Deb, Mojibur Rohman Khan

“…Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. …”
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Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…In recent years, PMNs have gained increasing recognition for their significant involvement in the pathogenesis of a wide array of human diseases, including sepsis, pulmonary conditions, autoimmune disorders, and various cancers. …”
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Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells by Simona Ronchetti, Erika Ricci, Maria Grazia Petrillo, Luigi Cari, Graziella Migliorati, Giuseppe Nocentini, Carlo Riccardi

“…Therefore, when evaluating changes in the number of Tregs in human diseases, GITR expression must be evaluated. Moreover, GITR should be considered as a marker for isolating Tregs.…”
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Dual graph-embedded fusion network for predicting potential microbe-disease associations with sequence learning by Junlong Wu, Liqi Xiao, Liu Fan, Lei Wang, Xianyou Zhu, Xianyou Zhu

“…Dysbiosis, or an imbalance in these microbial communities, is strongly linked to a variety of human diseases. Therefore, understanding the impact of microbes on disease is essential. …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…The pharmacological targeting of nAChRs, using small molecules or peptides, is a promising approach for the development of compounds for the treatment of various human diseases including inflammatory and neurogenerative disorders such as Alzheimer’s disease. …”
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Prediction of Associations between OMIM Diseases and MicroRNAs by Random Walk on OMIM Disease Similarity Network by Hailin Chen, Zuping Zhang

“…Increasing evidence has revealed that microRNAs (miRNAs) play important roles in the development and progression of human diseases. However, efforts made to uncover OMIM disease-miRNA associations are lacking and the majority of diseases in the OMIM database are not associated with any miRNA. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…In recent years, many researchers focused on bioinformatics analysis to explore new biomarkers for the diagnosis, treatment, and prognosis of human diseases. In this work, we obtain the traditional RNA sequencing data of OA patients from the GEO database. …”
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Noninvasive Optical Imaging and In Vivo Cell Tracking of Indocyanine Green Labeled Human Stem Cells Transplanted at Superficial or In-Depth Tissue of SCID Mice by Vikram Sabapathy, Jyothsna Mentam, Paul Mazhuvanchary Jacob, Sanjay Kumar

“…Stem cell based therapies hold great promise for the treatment of human diseases; however results from several recent clinical studies have not shown a level of efficacy required for their use as a first-line therapy, because more often in these studies fate of the transplanted cells is unknown. …”
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Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers by Shiyi Yu, Chengyang Jiang, Yawen Yang, Fei Cheng, Fangchen Liu, Chang Liu, Xue Gong

“…Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). …”
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Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Yoshikazu Nakaoka, Issei Komuro

“…In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders. …”
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Lipid Peroxidation and Antioxidant Activities of the Aqueous Rhizome Extract of Rheum officinale Baillon by Eugene Chang, Choon Young Kim

“…Generation of reactive oxygen species (ROS) is associated with dysregulation of antioxidant defense mechanisms and incidence of human diseases. The specific aim of this study was to investigate the lipid oxidation and antioxidant activity of aqueous extract of Rheum officinale Baillon rhizome in order to evaluate its potential as a future novel natural antioxidant resource and a functional ingredient in food and pharmaceutical formations. …”
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HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses. by Jiwon Yu, Junha Cha, Geon Koh, Insuk Lee

“…These findings suggest that HCNetlas has the potential to link disease-associated genes to cell types of action, facilitating development of cell type-resolved diagnostics and therapeutic strategies for complex human diseases.…”
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