Multidimensional library for the improved identification of per- and polyfluoroalkyl substances (PFAS) by Kara M. Joseph, Anna K. Boatman, James N. Dodds, Kaylie I. Kirkwood-Donelson, Jack P. Ryan, Jian Zhang, Paul A. Thiessen, Evan E. Bolton, Alan Valdiviezo, Yelena Sapozhnikova, Ivan Rusyn, Emma L. Schymanski, Erin S. Baker

“…Abstract As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages to chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). …”
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PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance by Vladimir T. Todorov

“…Furthermore, I discuss the need for generating of additional transgenic animal models which are more appropriate with regard to the role of the PPARgamma-dependent regulation of the renin gene expression in human diseases such as arterial hypertension and metabolic syndrome.…”
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The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases by Keshav Raj Sigdel, Ao Cheng, Yin Wang, Lihua Duan, YanLin Zhang

“…The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. …”
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Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…This cost-effective approach, akin to the setup of traditional 1D or 2D dPCR, holds the potential to advance the application of rAAV in cell and gene therapy for the treatment of human diseases.…”
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Challenges in classifying human chromosomal heteromorphisms using banding cytogenetics: From controversial guidelines to the need for a universal scoring system by Sílvia Pires, Paula Jorge, Thomas Liehr, Natália Oliva-Teles

“…Nonetheless, their clinical importance is increasingly under scrutiny, with several studies aiming to assess their influence on human diseases and susceptibilities, especially as they are seemingly part of the long noncoding RNAs in certain tissues. …”
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Aspergillus-Related Lung Disease by Alia Al-Alawi, C Frank Ryan, Julia D Flint, Nestor L Müller

“…Aspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases ranging in severity from trivial to life-threatening, depending on the host response. …”
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MAP: Mutation Arranger for Defining Phenotype-Related Single-Nucleotide Variant by In-Pyo Baek, Yong-Bok Jeong, Seung-Hyun Jung, Yeun-Jun Chung

“…Next-generation sequencing (NGS) is widely used to identify the causative mutations underlying diverse human diseases, including cancers, which can be useful for discovering the diagnostic and therapeutic targets. …”
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Prediction of Quantitative Traits Using Common Genetic Variants: Application to Body Mass Index by Sunghwan Bae, Sungkyoung Choi, Sung Min Kim, Taesung Park

“…With the success of the genome-wide association studies (GWASs), many candidate loci for complex human diseases have been reported in the GWAS catalog. …”
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RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

“…In addition, an emphasis has been placed on the clinical role of targeting aberrant splicing corrections in human diseases. The principal mechanisms of action behind this phenomenon are described, followed by a discussion of prospective development strategies and pertinent challenges.…”
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Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management by Adil Hassan, Yin Huang, Mahjabina, Otmilda Hapsari Sudiro, Xiangxiu Wang, Jingqin He, Yan Wei, Xiaoling Liao, Guixue Wang

“…Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. …”
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Computational Insights in DNA Methylation: Catalytic and Mechanistic Elucidations for Forming 3-Methyl Cytosine by Mansour H. Almatarneh, Ghada G. Kayed, Mohammednoor Altarawneh, Yuming Zhao, Amita Verma

“…Methylation at C5 position of cytosine (5 mC) is the most abundantly occurring methylation process at CpG island, which has been well known as an epigenetic modification linked to many human diseases. Recently, another methylation approach has been discovered to show that DNA methyltransferases (DNMTs) promote the addition of the methyl group at position 3 to yield 3 mC. …”
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Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

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EFFECT OF ELEVATED TEMPERATURE ON THE SURVIVAL OF DROSOPHILA MELANOGASTER INFECTED WITH A PATHOGENIC WOLBACHIA STRAIN by A. A. Strunov, Yu. Yu. Ilinskii, I. K. Zakharov, E. V. Kiseleva

“…This fact makes it promising for control of insect pests and transmitters of human diseases. Any symbiotic association is exposed to various stress factors: starvation, heat, cold, etc., which affect the symbiont interaction significantly. …”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

“…Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. …”
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High Sensitivity Method to Estimate Distribution of Hyaluronan Molecular Sizes in Small Biological Samples Using Gas-Phase Electrophoretic Mobility Molecular Analysis by Lan Do, Christen P. Dahl, Susanne Kerje, Peter Hansell, Stellan Mörner, Ulla Lindqvist, Anna Engström-Laurent, Göran Larsson, Urban Hellman

“…Difficulty to obtain large enough biopsies from human diseased tissue or tissue from animal models has also restricted the study of hyaluronan. …”
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miR-155: An Important Role in Inflammation Response by Jingyan Hu, Songli Huang, Xiaoli Liu, Yuan Zhang, Shengli Wei, Xiuhua Hu

“…The widespread involvement of miR-155 in human diseases has led to a novel therapeutic approach between Chinese and Western medicine.…”
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Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney by Sergio Veloso Brant Pinheiro, Ana Cristina Simões e Silva

“…In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced. …”
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Network-Based Protein Biomarker Discovery Platforms by Minhyung Kim, Daehee Hwang

“…The advances in mass spectrometry-based proteomics technologies have enabled the generation of global proteome data from tissue or body fluid samples collected from a broad spectrum of human diseases. Comparative proteomic analysis of global proteome data identifies and prioritizes the proteins showing altered abundances, called differentially expressed proteins (DEPs), in disease samples, compared to control samples. …”
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Altered MMP/TIMP ratios are frequently observed in several human diseases. During aging and disease progression, the extracellular matrix (ECM) undergoes structural changes in which elastin and collagens serve an essential role. …”
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A multiscale model of the bone marrow and hematopoiesis by Ariosto Silva, Alexander R. A. Anderson, Robert Gatenby

“…The bone marrow is necessary for renewal of all hematopoietic cells and critical for maintenance of a wide range of physiologic functions. Multiple human diseases result from bone marrow dysfunction. It is also the site in which liquid tumors, including leukemia and multiple myeloma, develop as well as a frequent site of metastases. …”
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