Genetic control of N-glycosylation of human blood plasma proteins by S. Zh. Sharapov, A. N. Timoshchuk, Y. S. Aulchenko

“…Large-scale population studies have shown that the levels of various plasma protein N-glycans are associated with many multifactorial human diseases. Observed associations between protein glycosylation levels and human diseases have led to the conclusion that N-glycans can be considered a potential source of biomarkers and therapeutic targets. …”
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Marine Natural Products Against Tuberculosis by Marcus Vinícius Nora De Souza

“…Natural products represent an outstanding source of compounds that play an important role in the treatment of human diseases. Due to the importance of nature as a source of new drug candidates, the aim of this review is to highlight the marine natural products, which exhibit antituberculosis activity, discovered between 2000 and 2005.…”
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Ataxin-2: a powerful RNA-binding protein by Lulu Li, Meng Wang, Lai Huang, Xiaoli Zheng, Lina Wang, Hongming Miao

“…This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pathways. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. …”
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CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma by Kangkang Yang, Yushuang Wang, Yuli Jian, Bo Wang, Hao Du, Yuqing Xia, Jianlei Bi, Meihua Guo, Zhi Li, Ning Wang

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Protein Oxidation in Breast Microenvironment: Nipple Aspirate Fluid Collected from Breast Cancer Women Contains Increased Protein Carbonyl Concentration by Ferdinando Mannello, Gaetana A. Tonti, Virginia Medda

“…Background: Protein carbonyl levels are the most frequently used biomarker of protein oxidation in several human diseases, including cancer. Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium from which nipple aspirate fluid can be collected and analysed to assess tissue metabolic activity. …”
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Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications by Hugo Felix Perini, Beatriz Sodré Matos, Carlo José Freire de Oliveira, Marcos Vinicius da Silva

“…Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in the treatment of various complex human diseases. This strategy enhances drug delivery by leveraging the innate properties of cellular components, thereby improving biocompatibility and targeting specificity. …”
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Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses by Alessandra L. Morassutti, Carlos Graeff-Teixeira

“…Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. …”
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An Emerging Role for IQGAP1 in Regulating Protein Traffic by Mahasin Osman

“…Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus, elucidating the mechanisms of cellular traffic will be important in order to understand the basis of a wide range of inherited and acquired human diseases. …”
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The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

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Applications of polymeric nanoparticles in drug delivery for glioblastoma by Shuhan Liu, Shuhan Liu, Shuhan Liu, Shuhan Liu, Bin Tan, Feng Wang, Feng Wang, Ying Yu

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Validation of a Diagnostic Microarray for Human Papillomavirus: Coverage of 102 Genotypes by Sarah Tuttleton Arron, Peter Skewes-Cox, Phong H. Do, Eric Dybbro, Maria Da Costa, Joel M. Palefsky, Joseph L. DeRisi

“…Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. …”
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The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…The database currently contains information on more than 70 billion associations between genetic variants and human diseases, quantitative traits, and “omics” traits. …”
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TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets by Nelson S. Yee, Ada S. Chan, Julian D. Yee, Rosemary K. Yee

“…Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. …”
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Review: Helicobacter pylori and extragastric diseases by J. Wizenty, M. Sigal

“…Besides gastric disease, infection is also thought to play a role in the development of other human diseases. H. pylori has been predominantly associated with gastrointestinal, metabolic, cardiovascular, respiratory, and neurological disorders. …”
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Preventing Foodborne Illness: Shigellosis by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“… Shigella is a Gram-negative, nonmotile, non-sporeforming, rod-shaped bacterium capable of causing disease in humans. Disease occurs when virulent Shigella organisms are consumed and invade the intestinal mucosa, resulting in tissue destruction. …”
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Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation by Aini Vuorinen, Cassandra R. Kennedy, Katherine A. McPhie, William McCarthy, Jonathan Pettinger, J. Mark Skehel, David House, Jacob T. Bush, Katrin Rittinger

“…Abstract Deubiquitinating enzymes (DUBs) are key regulators of cellular homoeostasis, and their dysregulation is associated with several human diseases. The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic interest, yet only a few tool compounds exist to study their cellular function and therapeutic potential. …”
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Preventing Foodborne Illness: Shigellosis by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“… Shigella is a Gram-negative, nonmotile, non-sporeforming, rod-shaped bacterium capable of causing disease in humans. Disease occurs when virulent Shigella organisms are consumed and invade the intestinal mucosa, resulting in tissue destruction. …”
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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. …”
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Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives by Marco A. Luís, Marcelo A. D. Goes, Fátima Milhano Santos, Joana Mesquita, Paulo Tavares-Ratado, Cândida Teixeira Tomaz

“…Monogenic disorders are a group of human diseases caused by mutations in single genes. While some disease-altering treatments offer relief and slow the progression of certain conditions, the majority of monogenic disorders still lack effective therapies. …”
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