The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

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Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses by Alessandra L. Morassutti, Carlos Graeff-Teixeira

“…Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. …”
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Validation of a Diagnostic Microarray for Human Papillomavirus: Coverage of 102 Genotypes by Sarah Tuttleton Arron, Peter Skewes-Cox, Phong H. Do, Eric Dybbro, Maria Da Costa, Joel M. Palefsky, Joseph L. DeRisi

“…Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. …”
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The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…The database currently contains information on more than 70 billion associations between genetic variants and human diseases, quantitative traits, and “omics” traits. …”
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TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets by Nelson S. Yee, Ada S. Chan, Julian D. Yee, Rosemary K. Yee

“…Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. …”
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Preventing Foodborne Illness: Shigellosis by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“… Shigella is a Gram-negative, nonmotile, non-sporeforming, rod-shaped bacterium capable of causing disease in humans. Disease occurs when virulent Shigella organisms are consumed and invade the intestinal mucosa, resulting in tissue destruction. …”
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Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation by Aini Vuorinen, Cassandra R. Kennedy, Katherine A. McPhie, William McCarthy, Jonathan Pettinger, J. Mark Skehel, David House, Jacob T. Bush, Katrin Rittinger

“…Abstract Deubiquitinating enzymes (DUBs) are key regulators of cellular homoeostasis, and their dysregulation is associated with several human diseases. The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic interest, yet only a few tool compounds exist to study their cellular function and therapeutic potential. …”
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Preventing Foodborne Illness: Shigellosis by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“… Shigella is a Gram-negative, nonmotile, non-sporeforming, rod-shaped bacterium capable of causing disease in humans. Disease occurs when virulent Shigella organisms are consumed and invade the intestinal mucosa, resulting in tissue destruction. …”
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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. …”
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Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives by Marco A. Luís, Marcelo A. D. Goes, Fátima Milhano Santos, Joana Mesquita, Paulo Tavares-Ratado, Cândida Teixeira Tomaz

“…Monogenic disorders are a group of human diseases caused by mutations in single genes. While some disease-altering treatments offer relief and slow the progression of certain conditions, the majority of monogenic disorders still lack effective therapies. …”
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Spatial and Temporal Distribution of Tuberculosis in the State of Mexico, Mexico by Adrian Zaragoza Bastida, Marivel Hernández Tellez, Lilia P. Bustamante Montes, Imelda Medina Torres, Jaime Nicolás Jaramillo Paniagua, Germán David Mendoza Martínez, Ninfa Ramírez Durán

“…Tuberculosis (TB) is one of the oldest human diseases that still affects large population groups. …”
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Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma by Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp

“…The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known to be related to human diseases. Systemic sequelae of MSD are vast and multisystemic, primarily encompassing developmental delay and neurological, cardiopulmonary, dermatological, gastroenterological, and skeletal manifestations. …”
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Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals by Wei Mao, Xingnan Ge, Qianping Chen, Jia-Da Li

“…Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. …”
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Pathogenicity of Virulent Species of Group C Streptococci in Human by Marta Kłos, Jadwiga Wójkowska-Mach

“…This report focuses mainly on the pathogenicity of virulent species of GCS and their association with human diseases. The condition that is most frequently quoted is pharyngitis. …”
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Alternative Cell Death Pathways and Cell Metabolism by Simone Fulda

“…A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.…”
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Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation by Tong Wang, Zhongwen Xing, Dingyu Xing

“…Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria.…”
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Cancer, Natural Products and Nanodrug Delivery Systems by Yong Sze Ong, Loh Teng-Hern Tan

“…One of the promising breakthroughs is the application of natural product-based nanoformulations for the treatment of various human diseases, such as cancer. Principally, the nanoparticle-based drug delivery system (NDDS) aims to overcome the limitations of conventional drug delivery system. …”
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EPA’s Endocrine Disruptor Screening Program (EDSP) by Frederick M. Fishel

“…The relationship between human diseases of the endocrine system and exposure to environmental contaminants is poorly understood and controversial. …”
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EPA’s Endocrine Disruptor Screening Program (EDSP) by Frederick M. Fishel

“…The relationship between human diseases of the endocrine system and exposure to environmental contaminants is poorly understood and controversial. …”
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ISOLATION AND STRUCTURAL CHARACTERIZATION OF TWO SAPONINS FROM THE ROOTS OF Sansevieria trifasciata ‘Laurentii’ by Duc Hung Nguyen, Quang Tan Tu, Hoang Mau Chu

“…Many Sansevieria species are used for ornamental purposes or in traditional medicine to treat human diseases. Sansevieria trifasciata ‘Laurentii,’ commonly known as snake plant, is an evergreen perennial plant used in traditional medicine. …”
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