Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…Therefore, the aim of the present study was to screen the phytoconstituents and identify the active compounds present in the methanolic extract of E. thymifolia (ME.ET) as ligands to inhibit human cancer cell lines with special reference to potential protein targets implicated in breast cancer using an In-silico approach. …”
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Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota by Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight

“…We determined the immunomodulatory effects of probiotic strain Lactobacillus casei Shirota (LcS) on human DC from healthy controls and active UC patients. …”
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CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis by YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li

“…Blocking CMPK2 or STING signalling significantly reduced the activation of NLRP3 in house dust mite (HDM)‐challenged mice and human nasal epithelial cells (HNEPCs).…”
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Genetic Polymorphism and Expression of CXCR4 in Breast Cancer by Marina Okuyama Kishima, Karen Brajão de Oliveira, Carolina Batista Ariza, Carlos Eduardo Coral de Oliveira, Roberta Losi Guembarovski, Bruna Karina Banin Hirata, Felipe Campos de Almeida, Glauco Akelinghton Freire Vitiello, Kleber Paiva Trugilo, Alda Fiorina Maria Losi Guembarovski, Walter Jorge Sobrinho, Clodoaldo Zago Campos, Maria Angelica Ehara Watanabe

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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Using Doberman Pinschers (DP) with DCM, which possess similarities with human DCM among these β1‐AAB positivity for that the disease‐driving role in DP DCM was demonstrated, the safety of BC 007, efficacy for neutralizing β1‐AAB, and the DP's outcome were investigated. …”
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Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma – A Cross-Sectional Study [version 1; peer review: 2 approved, 1 approved with reservations, 1 no... by Sekar Safitri, Rachmat Andi Hartanto, Rusdy Ghazali Malueka, Bo Sun, Ery Kus Dwianingsih, Kusumo Dananjoyo, Ahmad Asmedi, Endro Basuki, Christina Megawimanti Sianipar, Yeshua Putra Krisnugraha

“…Eighteen blood plasma samples from glioma patients and 6 healthy controls were analyzed for 798 human miRNA profiles using NanoString nCounter Human v3 miRNA Expression Assay. …”
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Unravelling the multi-scale structure of vertebrate scavenger communities: The role of beta-diversity in livestock carcass consumption by María Eugenia Cabrera-García, Patricia Mateo-Tomás, José Hernán Sarasola, Juan I. Zanón Martínez, Beatriz Martínez-Miranzo, Pedro P. Olea

“…We further evaluate the potential effect of carcass and habitat characteristics (including human impact) on the richness, abundance and diversity of vertebrate scavengers. …”
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A Proposed mHealth Intervention to Address Patient Barriers to Colposcopy Attendance: Qualitative Interview Study of Clinic Staff and Patient Perspectives by Jennifer R Hemler, Rachel B Wagner, Brittany Sullivan, Myneka Macenat, Erin K Tagai, Jazmarie L Vega, Enrique Hernandez, Suzanne M Miller, Kuang-Yi Wen, Charletta A Ayers, Mark H Einstein, Shawna V Hudson, Racquel E Kohler

“…However, the efficacious TC3 intervention is human resource-intense and could have greater reach if adapted for mobile health, which increases convenience and access to health information. …”
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Long-term smoking contributes to aging frailty and inflammatory response by Huijin Hou, Yidi Chai, Ting Zhang, Yue Liang, Lan Huang, Xu Cao, Shufang Liang

“…Among human samples, 69.2% of elderly smokers exhibited a frailty phenotype, compared to just 15.4% of non-smokers. …”
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Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

“…While the impact of advancing technologies on the environmental and human damage caused by earthquakes is still a subject of debate, search and rescue (SAR) teams and emergency departments (ED), specifically emergency physicians (EPs), play a crucial role in the most acute management of the effects of these earthquakes on human life. …”
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Characterization of Listeria monocytogenes strains isolated from soil under organic carrot farming by Maciej Nowak, Zbigniew Paluszak, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Anna Budzyńska, Joanna Skonieczna-Kurpiel, Ewa Wałecka-Zacharska, Monika Huse-Kutowska, Krzysztof Skowron

“…L. monocytogenes is isolated from soil, water, sewage, rotting vegetation, and the main source of these rods for humans is food (fish, unpasteurized dairy products, or raw fruits and vegetables). …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…Objectives Spondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. Human leucocyte antigen (HLA)-B27 is a genetic risk factor for SpA. …”
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Environmental impact assessment of rapeseed production using the LCA method: Part two: Life cycle impact assessment by Kiš Ferenc, Đurišić-Mladenović Nataša, Marjanović-Jeromela Ana

“…The study found that the total damage to human health was estimated at 0.0048 DALY, while damage due to biodiversity loss was calculated as 0.0001 species per year. …”
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Evaluasi Tata Kelola Sumber Daya Teknologi Informasi Menggunakan Kerangka Kerja COBIT 5 Subdomain EDM04, APO07 dan DSS03 pada Perusahaan Jasa Pelabuhan PT. XYZ by Audi Kresna Fathurino, Yusi Tyroni Mursityo, Aditya Rachmadi

“…Subomain yang terlibat diantaranya EDM04 (Ensure Resource Optimization) dan APO07 (Manage Human Resources) sebagai pengelolaan sumber daya, serta DSS03 (Manage Problems) sebagai pengelolaan permasalahan. …”
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Establishment of a Rapid and Convenient Fluoroimmunoassay Platform Using Antibodies Against PDL1 and HER2 by Ji Eun Choi, Hanool Yun, Hee-Jin Jeong

“…In this study, we developed a simple and rapid fluorescence-linked immunosorbent assay (FLISA) using fluorescent dye-conjugated antibody fragments against programmed cell death ligand 1 (PDL1) and human epithelial growth factor receptor 2 (HER2). …”
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Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues by Saúl Rojas-Sánchez, Nikolay G. Kolev, Christian Tschudi

“…Abstract To regain infectivity, Trypanosoma brucei, the pathogen causing Human and Animal African trypanosomiasis, undergoes a complex developmental program within the tsetse fly known as metacyclogenesis. …”
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Multilevel Cognitive Machine-Learning-Based Concept for Artificial Awareness: Application to Humanoid Robot Awareness Using Visual Saliency by Kurosh Madani, Dominik M. Ramik, Cristophe Sabourin

“…Inspired by early-ages human skills developments and especially by early-ages awareness maturation, the present paper accosts the robots intelligence from a different slant directing the attention to combining both “cognitive” and “perceptual” abilities. …”
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An Optimal Fourth-Order Finite Difference Scheme for the Helmholtz Equation Based on the Technique of Matched Interface Boundary by Dongsheng Cheng, Jianjun Chen, Guangqing Long

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Correlation of Hydronephrosis Index to Society of Fetal Urology Hydronephrosis Scale by Krishnan Venkatesan, Joel Green, Steven R. Shapiro, George F. Steinhardt

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A Serious Case of Poisoning Caused by Oral Ingestion of Water-Soluble Fertilizer by Wei Ye, Shirong Lin, Chengquan Zheng, Chunshui Cao

“…Current research is mostly focused on the impact of fertilizers on human health when they are ingested through food; the main form of this is chronic damage. …”
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