Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

“…Here we analyse single-cell genomic and transcriptomic alterations linked with chromothripsis in human p53-deficient medulloblastoma and neural stem cells (n = 9). …”
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Il luogo e il senso: creazione e significazione degli spazi nel mondo globale by Gambardella, Fabiana, Amodio, Paolo

“…These are the sober word that Victor Hugo makes the priest pronounce when, at the down of modern age, he looked on with prophetic dismay at the advent of printing with movable type, a revolution that would completely transform not only the face and features of the human being, but even the stones, the physical and material space of signification, the dimension of belonging and the sacred, that an “emancipated humanity” would change with the use of reason, undermining every form of dogmatic authority and its symbol. …”
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Analisis Sentimen Berbasis Aspek Pada Ulasan Pelanggan Restoran Menggunakan Algoritma Support Vector Machine (Studi Kasus: Depot Bamara) by Muhammad Fariz Firdaus, Dian Eka Ratnawati, Nanang Yudi Setiawan

“…Depot Bamara is a restaurant that has not been effective in utilizing customer reviews due to the lack of technology and human resources who are experts in implementing it. …”
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Klasifikasi Aktivitas Manusia Menggunakan Algoritme Computed Input Weight Extreme Learning Machine dengan Reduksi Dimensi Principal Component Analysis by M. Sofyan Irwanto, Fitra A. Bachtiar, Novanto Yudistira

“…Based on various approaches that have been used to recognize human activity, sensor-based techniques are known to be superior to other techniques such as computer vision-based techniques. …”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…Additionally, we analyzed changes in the cell transcriptomes and cancer EV profiles. Methods Two human melanoma cell lines (MV3 and A2058) with differential metastatic potential were studied in the 3D spheroid cultures. …”
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An online emergency medical management information system using mobile computing by Sarandis Mitropoulos, Christos Mitsis, Petros Valacheas, Christos Douligeris

“…Findings – It reduces the total time of the EMS procedures and it allows for an easier management of EMS, by providing a better allocation of human resources and a better geographical distribution of ambulances. …”
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Evaluation and Influencing Factors of Urban Blue-Green Space Publicness in Changsha by Zhang Chen, Zhang Nan, Zhu Peijuan, Qin Shuqian, Zhang Yong

“…Drawing on the theories of the human-land relationship and landscape ecology, we established an evaluation system for UBGS publicness based on the "element-function-structure" framework. …”
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Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…Furthermore, we found that highly-purified phage preparations did not activate mouse or human derived toll like receptor (TLR) 4 or TLR9 in HEKblue reporter assays. …”
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Assessing One Health integration in Somalia’s school curriculum for future pandemic preparedness by Ahmed Abdulkadir Hassan-Kadle, Aamir Muse Osman, Abas Mohamed Sharif

“…Abstract Background: The COVID-19 pandemic has highlighted the need for a holistic health approach, emphasizing the interconnectedness of human, animal, plant, and environmental health. Somalia faces significant health challenges, including drought, floods, disease outbreaks, and food and feed insecurity, underscoring the importance of integrating One Health (OH) concepts into its education system. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…Antitumor activity was quantified by caliper measurement and bioluminescence signal and used anti-human vimentin to measure residual PSCs.Results H84T BanLec CAR was successfully transduced and expressed by T cells which had robust expansion and retained central memory phenotype in both CD4 and CD8 compartments. …”
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Cortisol regulates neonatal lung development via Smoothened by Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang, Yan Gao, Siman Han, Yichang Jia, Yun Zhao, Yizheng Wang

“…To explore the effect of cortisol action on the SHH pathway on neonatal lung development, we generated a genetic mouse, in which leucine 116 (L112 in human) of SMO was mutated to alanine 116 (L116A, Smo a/a ) by the CRISPR-Cas9, based on sequence differences between human and mice. …”
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Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

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Modelling the air quality impacts of a zero emission zone scenario in the city of Milan by Andrea Piccoli, Valentina Agresti, Marco Bedogni, Giovanni Lonati, Guido Pirovano

“…The assessment of possible benefit of ZEZ on emissions, air quality and human health can be performed with a dedicated modelling chain. …”
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Iron deficiency in endure athletes by Michał Rogulski, Yauheniya Patarocha, Aleksandra Ślusarska, Jolanta Mędyk, Paulina Błasiak, Małgorzata Wirkijowska, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski

“…Conclusions: Iron is playing a key role in numerous metabolic functions of the human body. The disruption of the balance of iron leads to decreased athletic performance.   …”
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Influence of environmental variables and anthropogenic activities on soda-saline lakes chemistry in northern Tanzania: A remote sensing and GIS approach by Azaria Stephano Lameck, Brian Rotich, Abdalrahman Ahmed, Harison K. Kipkulei, Peto Akos, Emil Boros

“…This study employed Remote Sensing and Geographical Information Systems to explore the influence of environmental factors and human-induced land use/land cover changes on the chemistry of soda-saline lakes in Northern Tanzania. …”
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Ecological problem identification based on spatial and temporal dynamics of ecosystem quality: A case study by Rui Zhang, Huamin Liu, Zhichao Xu, Xinchuan Zhao, Lu Wen, Yi Zhuo, Lixin Wang

“…However, in recent years, the region’s ecosystem has faced increasing pressure due to rapid population growth, urbanization, industrialization, intensified human-land conflicts, and global climate change. …”
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Situating complexity: information behaviour in the contact zone by Hye Lim Joy Nam

“…This paper argues that contact and zone are both key aspects of information behaviour, as information encounters take place in specific sites, between diverse human and nonhuman agents with different levels of power and influence. …”
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A Relationships-based Algorithm for Detecting the Communities in Social Networks by Sevda Fotovvat, Habib Izadkhah, Javad Hajipour

“…The clustering of social networks is important for revealing the basic structures of social networks and discovering the hyperlink of systems on human beings and their interactions. Social networks can be represented by graphs where users are shown with the nodes of the graph and the relationships between the users are shown with the edges. …”
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