The potential synergistic effect of combining doxorubicin with vorinostat in urothelial carcinoma therapy by Cheng-Huang Shen, Shou-Chieh Wang, Kah-Min Lee, Hsin-Ting Liu, Szu-Wei Huang, Jin-Yi Wu, Yi-Wen Liu

“…We aim to investigate the combined effects and mechanisms of doxorubicin and vorinostat in human bladder cancer cells. Human bladder cancer cells (5637 and BFTC 905) were used in this study. …”
Get full text

Pembingkaian Perjuangan Tanah Orang Mentawai Dalam Konflik Kehutanan by Nurhayati Nurhayati, Afrizal Afrizal, Jendrius Jendrius

“…The geographical location and growth patterns have never been touched by human intervention, making the Mentawai forest have a unique composition. …”
Get full text

Association between the use of daily injury risk estimation feedback (I-REF) based on machine learning techniques and injuries in athletics (track and field): results of a prospect... by Karsten Hollander, David Blanco, Pascal Edouard, Laurent Navarro, Antoine Bruneau, Alexis Ruffault, Joris Chapon, Pierre-Eddy Dandrieux, Christophe Ley, Spyridon (Spyros) Iatropoulos

Get full text

A video intervention to improve patient understanding of tumor genomic testing in patients with cancer by Deloris J. Veney, Lai Y. Wei, Amanda E. Toland, Carolyn J. Presley, Heather L. Hampel, Tasleem J. Padamsee, Clara N. Lee, William J. Irvin Jr, Michael J. Bishop, James J. Kim, Shelly R. Hovick, Leigha A. Senter, Daniel G. Stover

Get full text

Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Introduction: Ebola virus (EBOV) is a highly lethal RNA virus that causes severe hemorrhagic fever in humans and non-human primates. The lack of effective treatment or vaccine for this pathogen poses a serious threat to a global pandemic. …”
Get full text

TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…These insights underscore TUBA1B’s multifaceted role in cancer progression and immune response.Conclusion: This study highlights TUBA1B’s potential as a human oncogene with substantial roles in tumorigenesis and immune regulation. …”
Get full text

Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. Here, we describe phage display-derived monoclonal antibodies (mAbs) 2C11 and 5C10 that bind human RGMb with high affinities of 1.4 nM and 0.72 nM, respectively. …”
Get full text

hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling by Mengbo Yang, Xinda Chen, Ming Zhang, Xiaolin Zhang, Dongdong Xiao, Huiming Xu, Mujun Lu

“…However, little is known about the effect of human umbilical cord mesenchymal stem cells (hUC-MSC) on CNI-ED. …”
Get full text

Renewed Global Partnerships and Redesigned Roadmaps for Rabies Prevention and Control by Tiziana Lembo, Michaël Attlan, Hervé Bourhy, Sarah Cleaveland, Peter Costa, Katinka de Balogh, Betty Dodet, Anthony R. Fooks, Elly Hiby, Fernando Leanes, François-Xavier Meslin, Mary Elizabeth Miranda, Thomas Müller, Louis H. Nel, Charles E. Rupprecht, Noël Tordo, Abbigail Tumpey, Alexander Wandeler, Deborah J. Briggs

“…Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. …”
Get full text

Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. …”
Get full text

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation by Yong Yi, Guoqiang Wang, Wenhua Zhang, Shuhan Yu, Junjie Fei, Tingting An, Jianqiao Yi, Fengtian Li, Ting Huang, Jian Yang, Mengmeng Niu, Yang Wang, Chuan Xu, Zhi-Xiong Jim Xiao

Get full text

Surveillance of tick-borne encephalitis virus foci in Slovakia: A seroprevalence study in ruminants combined with virus detection in ticks by Martina Ličková, Bronislava Víchová, Markéta Derdáková, Monika Sláviková, Sabína Fumačová Havlíková, Dana Zubriková, Diana Selyemová, Michal Chvostáč, Lucia Blaňarová, Viktória Čabanová, Veronika Vaňová, Lucia Šulejová, Jana Kerlik, Tomáš Szemes, Katarína Šoltys, Boris Klempa

“…The tick-borne encephalitis virus (TBEV) is an important human pathogen that causes tick-borne encephalitis, a potentially fatal neurological disease. …”
Get full text

Life cycle assessment of coconut plantation, copra, and charcoal production by T. Puspaningrum, N.S. Indrasti, C. Indrawanto, M. Yani

“…Normalization results showed that the category with enormous impacts on humans from coconut cultivation and copra processing activities had terrestrial ecotoxicity potential. …”
Get full text

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…The biocompatibility was assessed using an HFB4 normal human skin cell line. Methods The biocompatibility was evaluated using an HFB4 normal human skin cell line and the findings of pyrazole binding sites were confirmed using molecular docking. …”
Get full text

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…Remarkably, protein analysis in human brain tissue validated the observed upregulation of MCT4 and downregulation of P2RY12 in aged microglia. …”
Get full text

Microstructured Liquid Metal‐Based Embedded‐Type Sensor Array for Curved Pressure Mapping by Haoyu Li, Chengjun Zhang, Hongyu Xu, Qing Yang, Zexiang Luo, Cheng Li, Lin Kai, Yizhao Meng, Jialiang Zhang, Jie Liang, Feng Chen

“…Abstract Human hands can envelop the surface of an object and recognize its shape through touch. …”
Get full text

Habitat suitability modeling for Posidonia oceanica distribution along a Mediterranean region (NW Italy) by Rachele Bordoni, Chiara Paoli, Monica Montefalcone, Alice Oprandi, Ilaria Rigo, Francesca Ruggeri, Paolo Vassallo

“…Delile is a keystone seagrass species, playing a central role in the ecological balance of Mediterranean coastal areas but threatened by increasing human pressures. Proper management and conservation of coastal marine habitats require the understanding of its distribution. …”
Get full text

Hubungan Aktivitas Fisik terhadap Kadar Hemoglobin pada Mahasiswa Anggota UKM Pandekar Universitas Andalas by Laura Kosasi, Fadil Oenzil, Amel Yanis

“…<br />Kata kunci: Aktivitas Fisik, Kadar Hemoglobin, Mahasiswa Anggota UKM Pandekar</p><p>Abstract<br />Haemoglobin in red blood cells in human body is very important to transport the oxygen to all of the bodycells. …”
Get full text

Desain Media Pembelajaran dengan Model Problem-based Learning dan Gamitifikasi untuk Materi Bangun Ruang Tingkat SMK Berbasis Virtual Rality by Admi Rut Sinana, Herman Tolle, Fitra Abdurrachman Bachtiar

“…This study aims to describe, explain and analyze the design process of learning media using the Human-Centered Design (HCD) approach which is used in building VR applications using PBL and gamification models on a Learning Media, especially Geometry Subjects.In this study, there is one model that can be applied, namely Problem-Based Learning. …”
Get full text

Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes by Jersey Heitor da S. Maués, Helem Ferreira Ribeiro, Giovanny R. Pinto, Luana de Oliveira Lopes, Letícia M. Lamarão, Carla Mariana F. Pessoa, Caroline de Fátima Aquino Moreira-Nunes, Raimundo Miranda de Carvalho, Paulo P. Assumpção, Juan A. Rey, Rommel M. Rodríguez Burbano

Get full text