Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV an... by James Kiarie, Karel Blondeel, Igor Toskin, Jordi Casabona, Soe Soe Thwin, Massimo Mirandola, Rosanna Peeling, Ronald Ballard, Laura Fernàndez-López, Inga Upmace, Juliana Reyes-Urueña, Mara Vaselova, Mitja Ćosić, Simon Maljevac, William Mejías, Ander Pazos, Andrii Chernyshev

Get full text

The Effect of using the Smartphone in the Workplace on Job Engagement and Job Burnout: Investigation of Mediational Role of Stress by Somayeh Naghdi Zarrin, Neda Mohammad Esmaeili

Get full text

Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Background: Thyroid Hormones (THs) critically impact human cancer. Although endowed with both tumor-promoting and inhibiting effects in different cancer types, excess of THs has been linked to enhanced tumor growth and progression. …”
Get full text

Wildfire indicators modeling for reserved forest of Vellore district (Tamil Nadu, India) by Yara EzAl Deen Sultan, Kanni Raj Arumugam Pillai, Archana Sharma

“…In the Vellore district, the calculated activity danger index ranges from 0 to 12,000, showing that the high risk emanates from human activities. The climate is dry from May to July, and the weather danger index is 345–348. …”
Get full text

Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…The recently characterised human ZGRF1 helicase promotes genomic stability by facilitating DNA interstrand crosslink repair. …”
Get full text

Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…Methods. 29 samples of atherosclerosis-related gene expression profiling, including 16 human advanced atherosclerosis plaque (AA) and 13 human early atherosclerosis plaque (EA) samples from the Gene Expression Omnibus (GEO) database, were analyzed to get differentially expressed genes (DEGs) and the construction of protein and protein interaction (PPI) networks. …”
Get full text

Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior by Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua

“…In a model of glucocorticoid-mediated metabolic syndrome, CaMKII-CB1-RS mice showed all metabolic alterations linked to the human metabolic syndrome except of glucose intolerance. …”
Get full text

Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents by Amilton Dos Santos-Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Osmar Henrique Della Torre, Lúcia Arisaka Paes, Adriana Perez Ferreira-Neto, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo

Get full text

Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon by Menglu Chen, Lei Gao, Pan Chen, Dandan Feng, Yalin Jiang, Yongchao Chang, Jianjun Jin, Fong-Fong Chu, Qiang Gao

“…MMPs and tissue inhibitors of MMPs (TIMPs) mRNA were measured by real-time quantitative RT-PCR in mouse colon and in human Caco-2 cells and neutrophils. MMP-3 and MMP-9 protein levels were quantified from immunohistochemistry (IHC) images of mouse colons. …”
Get full text

Results from the PROmoting Early Childhood Outside cluster randomized trial evaluating an outdoor play intervention in early childhood education centres by Rachel Ramsden, Dawn Mount, Yingyi Lin, Emily Fox, Susan Herrington, Janet Loebach, Adina Cox, Anita Bundy, Amber Fyfe-Johnson, Ellen Beate Hansen Sandseter, Michelle Stone, Mark S. Tremblay, Mariana Brussoni

Get full text

scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers by Peng Tian, Jie Zheng, Keying Qiao, Yuxiao Fan, Yue Xu, Tao Wu, Shuting Chen, Yinuo Zhang, Bingyue Zhang, Chiara Ambrogio, Haiyun Wang

“…Based on the strong correlation between the NES and drug response at single‐cell resolution, scPharm successfully identified the sensitive subpopulations in ER‐positive and HER2‐positive human breast cancer tissues, revealed dynamic changes in the resistant subpopulation of human PC9 cells treated with erlotinib, and expanded its ability to a mouse model. …”
Get full text

The Usage of Lion’s Mane in Sports and Its Metabolic Impact – a literature review by Karolina Stankevič, Kamila Fuczyło, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Justyna Woźniak, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński

“…Preclinical studies are promising but need to be validated in well-designed human trials. …”
Get full text

Comparison of brain activity metrics in Chinese and Russian students while perceiving information referencing self or others by Q. Si, J. Tian, V. A. Savostyanov, D. A. Lebedkin, A. V. Bocharov, A. N. Savostyanov

“…One of the problems of neuroimaging technology is the creation of methods for studying human brain activity in socially oriented conditions by using modern information approaches. …”
Get full text

Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID by Andrea Polli, Lode Godderis, Dries S. Martens, Madhura Shekhar Patil, Jolien Hendrix, Arne Wyns, Jente Van Campenhout, Emma Richter, Lara Fanning, Olivia Vandekerckhove, Eveline Claeys, Wim Janssens, Natalie Lorent

Get full text

Pregnancy stressors and postpartum symptoms of depression and anxiety: the moderating role of a cognitive–behavioural therapy (CBT) intervention by Ahmed Zaidi, Atif Rahman, Pamela J Surkan, Najia Atif, Abid Malik, Yunxiang Sun, Soim Park

Get full text

Entrepreneurial Budgeting in the Iranian Government Budget: Obstacles and Solutions by Seyyed Mohammad Moghimi, Alireza Salmanian

Get full text

Measuring Bound Attention During Complex Liver Surgery Planning: Feasibility Study by Tim Schneider, Timur Cetin, Stefan Uppenkamp, Dirk Weyhe, Thomas Muender, Anke V Reinschluessel, Daniela Salzmann, Verena Uslar

“…However, the introduction of these innovations requires thorough evaluation in the context of human-machine interaction. Despite their potential benefits, new technologies can complicate surgical tasks and increase the cognitive load on surgeons, potentially offsetting their intended advantages. …”
Get full text

MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…The effects of MSC-EVs and UCB-EVs on human dermal fibroblast-adult cell (HDF-a) migration and proliferation were evaluated using cell scratch assays, cell migration assays, and cell proliferation assays. …”
Get full text

Phenolic Compounds in Agro-Industrial Waste of Mango Fruit: Impact on Health and Its Prebiotic Effect – a Review by Mayra Nicolás García, Anahí Jobeth Borrás Enríquez, Jorge Luis González Escobar, Oscar de Jesús Calva Cruz, Viridiana Pérez Pérez, Mayra Sánchez Becerril

“…Particularly, phenolic compounds hold a promising potential to be utilized as modulatory agents of the human gut microbiota (prebiotics-like actions). This review article mainly discusses the effect of phenolics from mango wastes on gut microbiota modulation and its beneficial repercussions for human health. …”
Get full text

Polystyrene nanoparticles induce DNA damage and apoptosis in HeLa cells by Antonia Feola, Manoj Madheswaran, Grazia Romano, Awet Ghebretinsae Tewelde, Eunice Wairimu Maina, Gianluca D'Abrosca, Maria della Valle, Mariacristina Cocca, Maria Emanuela Errico, Carla Isernia, Roberto Fattorusso, MariaTeresa Gentile, Gaetano Malgieri

“…Due to their small size and chemical composition, they can interact with biological systems in ways that larger plastic particles cannot. Humans are continuously exposed to NPs and several studies showed the potentially toxic effects of these latter on health. …”
Get full text