Nuclear talin-1 provides a bridge between cell adhesion and gene expression by Alejandro J. Da Silva, Hendrik S.E. Hästbacka, Mikael C. Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin T. Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen

“…By utilizing both subcellular fractionations and confocal microscopy analyses, we show that TLN1 localizes to the nucleus in several human cell lines, where it is tightly associated with the chromatin. …”
Get full text

Trap Assisted Dynamic Mechanoluminescence Toward Self‐Referencing and Visualized Strain Sensing by Tianli Wang, Pengfei Zhang, Jianqiang Xiao, Ziyi Guo, Xiongwu Xie, Jiahao Huang, Jiaojiao Zheng, Xuhui Xu, Lei Zhao

“…Leveraging the self‐referencing and color‐resolved (from green to red) visualized ML characteristics, an application scenario for monitoring human joint movement is developed. This approach offers new insights into the use of dynamic ML materials in strain sensing and human‐machine interaction.…”
Get full text

The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper by David J Wilson, Valérie Touitou, Justine R Smith, Manabu Mochizuki, Hiroshi Takase, Steven Yeh, Alexandra L Farrall, H Nida Sen, Daniel V Vasconcelos-Santos, Joke H de Boer, Ninette H ten Dam-van Loon, Janet L Davis, Anthony J Hall, Mark H B Radford

“…Outcomes of the project will include: (1) descriptions of clinical presentations, and diagnostic and therapeutic preferences; (2) associations between clinical presentations, and diagnostics and treatments, and between diagnostics and treatments (assessed by ORs with 95% CIs); and (3) estimations of rates of vision loss, and progression-free and overall survival (assessed by Kaplan-Meier estimates).Ethics and dissemination The registry has received Australia-wide approval by a national human research ethics committee. Sites located outside Australia are required to seek local human research ethics review. …”
Get full text

Machine Learning Model Reveals Land Use and Climate’s Role in Caatinga Wildfires: Present and Future Scenarios by Rodrigo N. Vasconcelos, Mariana M. M. de Santana, Diego P. Costa, Soltan G. Duverger, Jefferson Ferreira-Ferreira, Mariana Oliveira, Leonardo da Silva Barbosa, Carlos Leandro Cordeiro, Washington J. S. Franca Rocha

“…Using MaxEnt, fire probability maps were generated based on historical fire scars from Landsat imagery and environmental predictors, including bioclimatic variables and human influences. Future projections under SSP1-2.6 (low-emission) and SSP5-8.5 (high-emission) scenarios were also analyzed. …”
Get full text

Effects of music training on executive functions in preschool children aged 3–6 years: systematic review and meta-analysis by Yanan Lu, Lin Shi, Lin Shi, Ahmad Faudzi Musib

Get full text

Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

Get full text

Robust collection and processing for label-free single voxel proteomics by Reta Birhanu Kitata, Marija Velickovic, Zhangyang Xu, Rui Zhao, David Scholten, Rosalie K. Chu, Daniel J. Orton, William B. Chrisler, Tong Zhang, Jeremy V. Mathews, Benjamin M. Bumgarner, Demirkan B. Gursel, Ronald J. Moore, Paul D. Piehowski, Tao Liu, Richard D. Smith, Huiping Liu, Clive H. Wasserfall, Chia-Feng Tsai, Tujin Shi

“…Furthermore, wcSOP-MS is demonstrated to be broadly applicable for OCT-embedded and FFPE human archived tissues as well as for small-scale 2D proteome mapping of tissues at high spatial resolutions. wcSOP-MS may pave the way for routine robust single voxel proteomics and spatial proteomics.…”
Get full text

Machine learning reveals sex differences in distinguishing between conduct-disordered and neurotypical youth based on emotion processing dysfunction by Gregor Kohls, Erik M. Elster, Peter Tino, Graeme Fairchild, Christina Stadler, Arne Popma, Christine M. Freitag, Stephane A. De Brito, Kerstin Konrad, Ruth Pauli

Get full text

The association between 24-h movement behaviours and adiposity among Australian preschoolers: a compositional data analysis by Marga Decraene, Kar Hau Chong, Ty Stanford, Dorothea Dumuid, Penny Cross, Greet Cardon, Vera Verbestel, Marieke De Craemer, Anthony Okely

Get full text

A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…The influence of cancer on human society is indescribable. Human studies are often contradictory around the effects of polyphenols against cancer. …”
Get full text

Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2 by An W, Luo J, Zhang C, Xiao Q

“…However, ferroptosis-related genes (FRGs) have not been systematically identified and verified in AAD.Methods and Results: Seven human AAD datasets downloaded from Gene Expression Omnibus were analyzed, and 113 potential AAD-related FRGs were identified. …”
Get full text

Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination by Dongjin Oh, Nayoung Hong, Kiyoung Eun, Joohyeong Lee, Lian Cai, Mirae Kim, Hyerin Choi, Ali Jawad, Jaehyung Ham, Min Gi Park, Bohye Kim, Sang Chul Lee, Changjong Moon, Hyunggee Kim, Sang-Hwan Hyun

“…Herein, we developed a transgenic porcine melanoma model that closely resembles humans via somatic cell nuclear transfer (SCNT). Our model features the conditional oncogenes cassettes, TP53R167H and human BRAFV600E, controlled by melanocyte-specific CreER recombinase. …”
Get full text

Industry of employment and occupational class in relation to cardiovascular health by race/ethnicity, sex/gender, age and income among adults in the USA: a cross-sectional study by Symielle A Gaston, Chandra L Jackson, Jamie A Murkey, Dana M Alhasan, W Braxton Jackson

Get full text

Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

Get full text

How does gut microbiota affect the vaginitis axis? The mediating role of plasma metabolites by Mo Li, Qianyu Zhang, Tong Wu, Lanfang Ma, Dianxing Hu, Zixuan Yuan, Shixuan Wang, Aiyue Luo, Jinjin Zhang

“…However, the underlying etiological factors remain poorly understood, leading to recurrent vaginitis and constraining clinical management. Besides, the human gut and vagina are important organs that are both colonized by thousands of microorganisms impacting human physiology and health. …”
Get full text

Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

“…Loss-of-function experiments were performed in multiple human cancer cell lines using siRNA-mediated knockdown or CRISPR-Cas9 gene knockout. …”
Get full text

Considerations for Establishing a Behavioral Policy-Making and Nudge Institution within the Country's Executive Structure by Seyed Kamal Vaezi, Maryam Darbandi

“…ObjectivePublic interest in behavioral interventions within the field of public policy has expanded significantly in recent years, largely due to a growing understanding of human behavior and decision-making. In Iran, there is increasing recognition of the need for both theoretical and practical considerations in the adoption of behavioral policy-making. …”
Get full text

STRATEGI DINAS KOMUNIKASI DAN INFORMATIKA KABUPATEN BOJONEGORO DALAM PENERAPAN SISTEM PEMERINTAHAN BERBASIS ELEKTRONIK (SPBE) DI KABUPATEN BOJONEGORO by Nisa Safaatin, Ertien Rining Nawangsari

“…In its implementation, there are several problems, namely the SPBE index, which is still not optimal, lack of IT knowledge in human resources, and infrastructure, which is still uneven. …”
Get full text

Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite by Pilavadi Thangamuniyandi, Devan Umapathy, Loganathan Nagarajan, Antony Joseph Velanganni Arockiam

“…Further, the blue-LED assisted anti-cancer studies (MTT assay) using 0.015-Au-ZnO towards human lung cancer cells (A549), breast cancer cells (SKBr3) show high anti-proliferation rate and low cytotoxicity against healthy human embryonic kidney cells (HEK-293) with an IC50 value of 65, 53 and 124 μg/mL respectively. …”
Get full text

DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…To assess the functionality of the NPs, physicochemical characterization, safety tests, and transfection assay were employed to evaluate the NPs’ behavior in vitro and in vivo, in a human/zebrafish lymphoma xenograft model.ResultsThe results demonstrated that the PLGA-PVA nanoplatform was capable of efficiently encapsulating and releasing the payload. …”
Get full text