In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…Surface-exposed proteins that were antigenic, non-allergenic, and non-homologous to human proteins were selected for further analysis. …”
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The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer by Stefanie Seitz, Tobias F. Dreyer, Christoph Stange, Katja Steiger, Dirk Wohlleber, Martina Anton, Thuý An Pham, Dominique Sauter-Peschke, Ute Reuning, Gabriele Multhoff, Wilko Weichert, Marion Kiechle, Viktor Magdolen, Holger Bronger

“…Moreover, PARP inhibitors are able to increase CX3CL1 release from human ovarian cancer cells. Collectively, our study shows that CX3CL1 is a driver of intraperitoneal tumour growth in ovarian cancer, a feature that may compromise the anticancer effect of CX3CL1-inducing PARP inhibitors.…”
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Legacy and emerging organic pollutants in indoor and outdoor environments in Africa: Contamination levels, health risks, and analytical techniques by Godfrey Muhwezi, Christine Kyarimpa, Ivan Gumula, Christine Betty Nagawa, Solomon Omwoma, Henry Matovu, Julius Matsiko, Silver Odongo, Douglas Sifuna, Ivan Špánik, Charles Drago Kato, Patrick Ssebugere

“…Herein we reviewed literature published for the period 2000–2023 on selected LOPs and EOPs in indoor dust and outdoor air in Africa to understand the occurrence, associated human health risks and common analytical techniques used to identify and quantify these contaminants. …”
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Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain by Andrew Silberfeld, James M. Roe, Jacob Ellegood, Jason P. Lerch, Lily Qiu, Yongsoo Kim, Jong Gwan Lee, William D. Hopkins, Joanes Grandjean, Yangming Ou, Olivier Pourquié

“…Left-right asymmetry of the human brain is widespread through its anatomy and function. …”
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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Similar KPNA2 expression pattern was also found in both human patient samples and KPC mouse models through IHC staining. …”
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Transformers for Neuroimage Segmentation: Scoping Review by Maya Iratni, Amira Abdullah, Mariam Aldhaheri, Omar Elharrouss, Alaa Abd-alrazaq, Zahiriddin Rustamov, Nazar Zaki, Rafat Damseh

“…Manual segmentation is time-consuming, apart from being prone to human error and variability. Transformers are a promising deep learning approach for automated medical image segmentation. …”
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Towards Understanding the Security of Modern Image Captchas and Underground Captcha-Solving Services by Haiqin Weng, Binbin Zhao, Shouling Ji, Jianhai Chen, Ting Wang, Qinming He, Raheem Beyah

“…Fourth, we compare our attacks against nine online image recognition services and against human labors from eight underground captcha-solving services. …”
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Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF by Gita Pratama, Elizabeth Agustina, Atika Mahira Yanfaunnas, Mila Maidarti, Achmad Kemal Harzif, R. Muharam, Budi Wiweko

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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…Software agents are computer programs that can hold conversations with a human by mimicking a human conversational style. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

“…This study aims to develop and test an in vitro tri-culture model, simulating the complexity of the intestinal tract and its multiple cell interactions.MethodsTo achieve this, the intestinal epithelial barrier was established by co-culturing human Caco-2 enterocyte-like and HT29-MTX-E12 mucus producing goblet-like colon cells, then adding human monocyte THP-1 cells to the basolateral compartment. …”
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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Precisely quantifying their plasma levels is crucial for clinical pharmacokinetic assessments and therapeutic drug monitoring.Aim: This study aimed to establish a generic and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay for the determination of five PPIs (esomeprazole, rabeprazole, ilaprazole, lansoprazole, and pantoprazole) and the P-CAB (vonoprazan) in human plasma.Methods: The six analytes were extracted from human plasma via protein precipitation and a single dilution step. …”
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LOW PREVALENCE OF COVID-19 IN LAOS AND CAMBODIA: DOES DIET PLAY A ROLE? by Geir Bjorklund, Roman Lysiuk, Monica Butnariu, Larysa Lenchyk, Vineet Sharma, Rohit Sharma, Natalia Martins

“…Coronavirus disease (COVID-19) outbreak is an ongoing pandemic caused by a highly pathogenic human coronavirus known as SARS-CoV2. Current epidemiology reported that more than 500 million cases of COVID-19 occurred in more than 180 countries worldwide. …”
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Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines by Valerio Pazienza, Francesca Tavano, Massimo Francavilla, Andrea Fontana, Fabio Pellegrini, Giorgia Benegiamo, Vincenzo Corbo, Fabio Francesco di Mola, Pierluigi Di Sebastiano, Angelo Andriulli, Gianluigi Mazzoccoli

“…In conclusion, PPARG and DNMTs expression is characterized by different time-qualified patterns in cell lines derived from human PC, and this heterogeneity could influence cell phenotype and human disease behaviour.…”
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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…The HFD-Renin mouse model recapitulates key features of human HFpEF and will enable studies dissecting the contribution of individual pathogenic drivers to this complex syndrome. …”
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N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Abstract Background Seipin is a protein encoded by the BSCL2 gene in humans and SEI1 gene in yeast, forming an Endoplasmic Reticulum (ER)-bound homo-oligomer. …”
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UPLC-ESI-MS/MS Profile and Antioxidant, Cytotoxic, Antidiabetic, and Antiobesity Activities of the Aqueous Extracts of Three Different Hibiscus Species by Hanan M. Al-Yousef, Wafaa H. B. Hassan, Sahar Abdelaziz, Musarat Amina, Rasha Adel, May A. El-Sayed

“…Hibiscus micranthus showed the most potent effect on HCT-116 (human colon carcinoma) with IC50 = 56 ± 1.9 μg/mL compared with cisplatin (IC50 = 7.53 ± 3.8 μg/mL). …”
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A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods by Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke

“…This fast, cost-effective, robust, and reliable assay demonstrates the feasibility to use high-throughput PCR-based methods for detection of human pathogenic viruses in ps-iPSC lines that were generated with nongenome integrating reprogramming methods.…”
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Migration, race, and gender: the policing of subversive solidarity actors in Morocco by Sébastien Bachelet, Maria Hagan

“…The intimidation of those who support migrant people and seek to denounce human rights abuses against them has become an important dimension of border control. …”
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Nutritional intake of micronutrient and macronutrient and type 2 diabetes: machine learning schemes by Mohammad Rashidmayvan, Amin Mansoori, Elahe Derakhshan-Nezhad, Davoud Tanbakuchi, Fatemeh Sangin, Maryam Mohammadi-Bajgiran, Malihehsadat Abedsaeidi, Sara Ghazizadeh, MohammadReza Mohammad Taghizadeh Sarabi, Ali Rezaee, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

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QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis by Min Li, Mengxue Gao, Jinmei Huang, Shaojuan Jin, Yamei Lv, Lin Wang, Tao Huang, Fengcai Wu, Zhijian Xu, Yinghua Pan, Zhixia Liu, Chaopu Zhang, Yuntao Liang, Lijun Meng, Jianlong Xu

“…Abstract Background Toxic heavy metal elements in soils are major global environmental issues and easily migrate to crop grains to cause severe problems in human health, whereas moderately essential elements such as selenium are beneficial for human health. …”
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