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Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy
Published 2014-01-01“…It is known that the interleukin-4 receptor α (IL-4Rα) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4Rα-lytic hybrid peptide composed of binding peptide to IL-4Rα and cell-lytic peptide and reported that the designed IL-4Rα-lytic hybrid peptide exhibited cytotoxic and antitumor activity both in vitro and in vivo against the human pancreatic cancer cells expressing IL-4Rα. …”
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Potential of emodepside for vector-borne disease control
Published 2025-01-01“…Abstract Background Emodepside is an anthelmintic used in veterinary medicine that is currently under investigation in human clinical trials for the treatment of soil-transmitted helminths and possibly Onchocerca volvulus. …”
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Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study
Published 2025-01-01“…During 2007–2015, we estimated that 88.5% of human lineages arose from cattle lineages. We identified 11 persistent lineages local to Alberta, which were associated with 38.0% (95% CI 29.3%, 47.3%) of human isolates. …”
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Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems
Published 2017-12-01“…Lactaptin, a proteolytic fragment of the human milk kappa-casein, has been previously identified as a protein displaying potent killing of cancer cells in vitro. …”
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DEFORMATION PRACTICES OF SOCIAL REALITY INTEGRITY: OBJECTIFICATION OF DESIRES AS THE INHERITANCE OF CIVILIZATION PROGRESS
Published 2014-12-01“…The desire to own, exploit, use makes a human to devalue surrounding reality and its members, turns a human into a homo economics, who calculates his circle of friends, communication, relationships. …”
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The impact of gestational age limits on abortion-related outcomes: a synthesis of legal and health evidence
Published 2025-02-01“…Methods This paper synthesizes the results of a systemic review with the identification and application of relevant international human rights standards. A search strategy was drawn up to capture public health, international human rights law, and policy evidence related to the impacts of GLs. …”
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Comparative study of packaging materials developed from fish and legume protein concentrates
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Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Published 2025-01-01“…We then discuss the potential roles and deregulation of CDKs in human pathologies, with a particular focus on cancer, the human disease in which CDKs have been most extensively studied and explored as therapeutic targets. …”
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Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy
Published 2024-12-01“…It also found that FN NP induced cell death in the mouse colorectal cancer cell line CT26 and human prostate cancer cell line PC-3, but not in the human prostate cancer cell line LNCaP. …”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering
Published 2023-01-01“…In this study, we utilised 40 total-body [18F] fluorodeoxyglucose PET images of rats to mimic the coming large human PET images and a few actual human total-body images to ensure that our conclusions from the rat data generalise to the human data. …”
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Les genres récrits : chronique n° 6
Published 2019-12-01“…The term gender is used today with different meanings in linguistics, but also more generally in social and human sciences. It applies to nouns, human beings and “glasses” through which social facts are studied. …”
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Wybrane problemy i dylematy społecznoekonomicznego wartościowania relacji człowiek - środowisko naturalne
Published 2007-12-01“…In this article autor shows the relation between human and natural environment and the chosen problems connected with this especially social, technological, economical with ecological and law problems and dilemmas connected with ecological safety of the human and the whole biosphere.…”
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