An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Filterable PM2.5, Metallic Elements, and Organic Carbon Emissions from the Exhausts of Diesel Vehicles by Yuan-Chung Lin, Ya-Ching Li, Kassian T. T. Amesho, Feng-Chih Chou, Pei-Cheng Cheng

“…Abstract Urban air pollution in the form of fine particulate matter (PM2.5) poses a substantial health threat to humans via inhalation. To assess the risks from this pollutant, we characterized and quantified the PM2.5 exhausted by 15 diesel vehicles ranging from 28,306 to 883,374 km (an average of 525,854 km) in total mileage and varying in manufacturer and model year (1988–2005). …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Typhimurium, ST) is a food-borne pathogen that can be transmitted from animals to humans and causes symptoms such as diarrhea, fever, and vomiting. …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…The species of Tabanus, commonly known as horse flies, are remarkable ectoparasites capable of transmitting various pathogens to animals and humans. Given their role in disease transmission, accurate identification of horse fly species is critical but traditionally relies on morphological characteristics, requiring significant expertise and posing a high potential for error, especially with damaged specimens. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Herein, we identified the neuronal chemokine CCL21 as a major cause of microglial cell imbalance through the CCR7 receptor pathway with therapeutic implications for PD. In humans, we found that CCL21 transcript expression was increased in dopaminergic neurons (DANs) of the substantia nigra in PD patients. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…At diet-induced NAFLD the liver undergoes a complex of histological and metabolic disorders to the high extent close to clinical symptoms of this disease in humans.Conclusion. There is a set of various ways of NAFLD modelling in animals. …”
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Key components in the professional ethics of sign language interpreters in healthcare contexts: a qualitative study in Colombia by Nora Ellen Groce, Samia Hurst, Laura Catalina Izquierdo Martínez, Angela Martínez-R, Jessica Cuculick, Minerva C Rivas Velarde

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Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…We explored these parameters in ocular tumour-associated genes.Methods A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists. …”
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Government Support and Local Residents’ Behavior in E-waste Management: Evidence from Thailand by Peeranart Kiddee, Somsiri Decharat, Suttiporn Bunmak

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Exposure to perchlorate via drinking water from eight major water basins in China and its health risks across different age groups by Jia Lyu, Yongyan Chen, Lan Zhang, Xu Yan, Muyesaier Tudi

“…Considering the endocrine-disrupting properties of perchlorate, the possibility of perchlorate exposure to humans through drinking water has become a public health concern. …”
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Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies. by Peter R McIlroy, Le Thanh Mai Pham, Thomas Sheffield, Maxwell A Stefan, Christine E Thatcher, James Jaryenneh, Jennifer L Schwedler, Anupama Sinha, Christopher A Sumner, Iris K A Jones, Stephen Won, Ryan C Bruneau, Dina R Weilhammer, Zhuoming Liu, Sean Whelan, Oscar A Negrete, Kenneth L Sale, Brooke Harmon

“…Previously, we designed a next-generation synthetic humanized nanobody (Nb) phage display library and demonstrated that this library could be used to rapidly identify highly specific and potent neutralizing heavy chain-only antibodies (HCAbs) with prophylactic and therapeutic efficacy in vivo against the original SARS-CoV-2. …”
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Risk factors for emergency presentation with lung and colorectal cancers: a systematic review by Una MacLeod, Elizabeth D Mitchell, Benjamin Pickwell-Smith

“…Objective To identify patient and practitioner factors that influence cancer diagnosis via emergency presentation (EP).Design Systematic review.Data sources MEDLINE, EMBASE, CINAHL, EBM Reviews, Science and Social Sciences Citation Indexes, Conference Proceedings Citation Index-Science and Conference Proceedings Citation Index-Social Science and Humanities. Searches were undertaken from 1996 to 2014. …”
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Muscle Architecture of Leg Muscles: Functional and Clinical Significance by Gurpreet Kaur, Rekha Lalwani, Manal M. Khan, Sunita A Athavale

“…Arching of the foot and eversion are peculiar to humans and recent in evolution. Due to the functional demand of maintaining the medial longitudinal arch and eversion, the tibialis anterior and peroneus longus have more muscle weight and larger physiological cross-sectional area and are potentially more powerful. …”
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Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport by Wang-Jong Lee, Ernest Mazigo, Jin-Hee Han, Seok Ho Cha

“…Abstract Plasmodium vivax is the most widespread malaria parasite affecting humans, and its eradication is challenging due to the spread of drug-resistant parasites and their ability to remain in liver as a dormant stage. …”
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‘Shift’ Adaptation and a New Croatian Standard for Haavikko Developmental Stages’ Timing by Ivan Bedek, Jelena Dumančić, Tomislav Lauc, Miljenko Marušić, Ivana Čuković-Bagić

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Respirable Particles and Gas Contaminants Emissions from a Desktop Laser Cutter and Engraver by Kevin O’Neill, Xinyi Niu, Jun Wang, Runcheng Fang

“…These contaminants include respirable particulates, volatile organic compounds (VOCs), and other toxic substances that pose health risks to humans. As desktop laser cutting/engraving technology gains popularity, addressing the potential health hazards associated with airborne contaminants is critical. …”
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Exploring the solutions of tempered (κ,ϖ)-Hilfer hybrid implicit boundary value problem by Abdelkrim Salim, Sabri T.M. Thabet, Ava Sh. Rafeeq, Mohammad Esmael Samei, Imed Kedim, Miguel Vivas-Cortez

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Investigation of Enterotoxigenic Coagulase-negative Staphylococci Isolated from Local and Imported Dairy Products; a Microbiological Study by Niyaz Sirwan Ali, Huner Hiwa Arif

“…Research interest in CNS has increased over the past decade following their implication in infections in animals and humans. This study was aimed to detect CNS isolated from 150 dairy products (yoghurt, several types of cheese, Lork, and Serezh) in Sulaimani and Halabja governorate. …”
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Gastronomy vs gastro-anomie? Japan’s foodscape by А. V. Malov, S. V. Chugrov

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Akin Ogundiran: The Historian and Archaeologist of Yoruba-Atlantic becomes Chancellor Professor at the University of North Carolina at Charlotte by Toyin Falola

“…And if, as he treats the local, he engages in issues around production and trade—as all his objects indicate—he is forced to engage in the understanding of how society relates to nature: that is, how humans ultimately relate to their environments, using and destroying them at the same time, and sometimes renewing them as well. …”
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