A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers by Wael Abu Dayyih, Mohammed Hamad, Ahmad Abu Awwad, Eyad Mallah, Zainab Zakarya, Alice Abu Dayyih, Tawfiq Arafat

“…A linearity, specific, accurate, and precise method was developed and applied for the analysis of enalapril and enalaprilat in human plasma after oral administration of two formulae of enalapril 20 mg tablets in healthy volunteers. …”
Get full text

Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation by Katja C. Weisel, Frank Bautz, Gabriele Seitz, Sedat Yildirim, Lothar Kanz, Robert Möhle

“…However, the role of this compartment and of the chemokine receptor CXCR4 is still under discussion, and only scarce data exist about CXCR4 function in human PMN. In our study, we provide evidence that also in human neutrophils, expression (cell surface and mRNA), chemotactic and signaling functions of the homing-related chemokine receptor CXCR4 are upregulated during aging in vitro, independent of addition of stimulatory cytokines (TNF, IL-1, IL-8, G-CSF). …”
Get full text

Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases by Eun Ji Lee, Jong Hoon Park

“…Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. …”
Get full text

Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury by Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park

“…In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). …”
Get full text

Tool Used to Assess Co-Benefits of Nature-Based Solutions in Urban Ecosystems for Human Wellbeing: Second Validation via Measurement Application by Karmele Herranz-Pascual, Paula Anchustegui, Carolina Cantergiani, Ioseba Iraurgi

Get full text

Artificial simulated saliva, gastric and intestinal digestion and fermentation in vitro by human gut microbiota of intrapolysaccharide from Paecilomyces cicadae TJJ1213 by Juanjuan Tian, Xiaomeng Wang, Xueliang Zhang, Xiaohong Chen, Mingsheng Dong, Xin Rui, Qiuqin Zhang, Mei Jiang, Wei Li

“…Food Science and Human Wellness…”
Get full text

Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

Get full text

Practical Recommendations of Scientific Society for the Study of Human Microbiome and Russian Gastroenterological Association (RGA) for Probiotics in Treatment and Prevention of Gastroenterological Diseases in Adults by V. T. Ivashkin, I. V. Mayev, D. I. Abdulganieva, S. A. Alekseenko, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammaev, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, O. Yu. Zolnikova, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, A. I. Ulyanin

Get full text

Calcium Chloride vs. Mechanical Preparation of Fibrinogen-Depleted Human Platelet Lysate: Implications for Umbilical Cord Mesenchymal Stem Cell Culture by Yen Theng Lim, Muttiah Barathan, Yu Ling Tan, Yi Ting Lee, Jia Xian Law

Subjects: Get full text

Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems by Vitale Miceli, Mariangela Pampalone, Serena Vella, Anna Paola Carreca, Giandomenico Amico, Pier Giulio Conaldi

“…In our study, we show that a three-dimensional (3D) culture method is effective to induce MSC spheroid formation, to maintain the multipotency and to improve the paracrine activity of a specific population of human amnion-derived MSCs (hAMSCs). The regenerative potential of both 3D culture-derived conditioned medium (3D CM) and their exosomes (EXO) was assessed against 2D culture products. …”
Get full text

Effects of Polygonatum sibiricum Polysaccharides (PSP) on Human Esophageal Squamous Cell Carcinoma (ESCC) via NF-κB Signaling Pathway by Weizheng Zhou, Jiang Hong, Ji Zhu, Xiaowei Wang

“…To explore the effects of different concentrations of Polygonatum sibiricum polysaccharides (PSP) on human esophageal squamous cell carcinoma (ESCC) cell line Eca109 and explore the new approach for the treatment of ESCC. …”
Get full text

Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures by Jun Liu, Claire A. Higgins, Jenna C. Whitehouse, Susan J. Harris, Heather Crawford, Angela M. Christiano, Majlinda Lako, Nicholas Hole, Colin A. B. Jahoda

“…Finally, we show that cultured mouse follicle dermal cells provide good stromal support for haematopoiesis in an established coculture model. Human follicular dermal cells represent an accessible and readily propagated source of feeder cells for pluripotent and haematopoietic cells and have potential for use in clinical applications.…”
Get full text

Enhancing the development of technology and partnership-based business incubator models in indonesia: the role of human resource availability, industry connections, and access to finance by Arief Yanto Rukmana, Mokhamad Syaom Barliana, Isma Widiaty, HR. Aam Hamdani, Ade Gafar Abdullah, Nining Harnani, Ridma Meltareza, Budi Harto

Subjects: Get full text

Detection of CRISPR‒Cas and type I R–M systems in Klebsiella pneumoniae of human and animal origins and their relationship to antibiotic resistance and virulence by Xue Li, Ling Wang, Jinghuan Lin, Yingjuan Gu, Zhihua Liu, Jing Hu

“…The results showed that host origin had no obvious influence on the distributions of the two systems (CRISPR‒Cas systems in 29.8% and 24.1%, type I R-M systems in 9.8% and 11.8% of human-origin and animal-origin strains, respectively) in K. pneumoniae. …”
Get full text

Essential Oil Content of the Rhizome of Curcuma purpurascens Bl. (Temu Tis) and Its Antiproliferative Effect on Selected Human Carcinoma Cell Lines by Sok-Lai Hong, Guan-Serm Lee, Syarifah Nur Syed Abdul Rahman, Omer Abdalla Ahmed Hamdi, Khalijah Awang, Nurfina Aznam Nugroho, Sri Nurestri Abd Malek

“…In this study, the hydrodistilled dried ground rhizome oil was investigated for its chemical content and antiproliferative activity against selected human carcinoma cell lines (MCF7, Ca Ski, A549, HT29, and HCT116) and a normal human lung fibroblast cell line (MRC5). …”
Get full text

Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorin f in Human Breast Cancer Cells: A Diffusion Kinetics Study by Ping Chen, Feng Zhang, Lei Zhang, Song-Cheng Mao, Lie Lin, Hua Bai, Guo-Qing Tang, Jian-Zhong Yao, Jun-Hong Yang, Yun-Feng Ma

“…The kinetics of photosensitizer 2-devinyl-2-(1-methoxylethyl) chlorin f (CPD4) uptake in MCF-7 human breast cancer cells is described by a diffusion kinetics model and experimentally investigated using laser scanning confocal microscopy (LSCM). …”
Get full text

Author Correction: A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain by Pere Gelabert, Victoria Oberreiter, Lawrence Guy Straus, Manuel Ramón González Morales, Susanna Sawyer, Ana B. Marín-Arroyo, Jeanne Marie Geiling, Florian Exler, Florian Brueck, Stefan Franz, Fernanda Tenorio Cano, Sophie Szedlacsek, Evelyn Zelger, Michelle Hämmerle, Brina Zagorc, Alejandro Llanos-Lizcano, Olivia Cheronet, José-Miguel Tejero, Thomas Rattei, Stephan M. Kraemer, Ron Pinhasi

Get full text

IoT-Based a Control System for Household Waste Management Machines at Waste Disposal Sites using Human Machine Interface Method by Pawenary pawenary, Hendri Hendri, Dwi Listiawati, Andi Dyah Harum Hardyanti, Yessy Asri, Anton Satria Prabuwono

Get full text

Reconstruction and computer analysis of the structural and functional organization of the gene network regulating cholesterol biosynthesis in humans and the evolutionary characteristics of the genes involved in the network by A. D. Mikhailova, S. A. Lashin, V. A. Ivanisenko, P. S. Demenkov, E. V. Ignatieva

“…Cholesterol is an essential structural component of cell membranes and a precursor of vitamin D, as well as steroid hormones. Humans and other animal species can absorb cholesterol from food. …”
Get full text

Neu5Ac Induces Human Dental Pulp Stem Cell Osteo-/Odontoblastic Differentiation by Enhancing MAPK/ERK Pathway Activation by Changzhou Li, Xinghuan Xie, Zhongjun Liu, Jianhua Yang, Daming Zuo, Shuaimei Xu

“…DPSCs were isolated from human third permanent teeth and were grown in vitro. …”
Get full text