Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.…”
Get full text

Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…The normal inflammatory response to acute infection displays remarkable circadian rhythmicity in humans with increased inflammatory activity during the normal night or rest period. …”
Get full text

A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system by Ke He, Kaidi Zhao, Tingyi Yin, Meng Liu, Jiashu Liu, Wenqian Du, Xinyi Liu, Baochen Cheng, Dewu Zhang, Yan Zheng

“…Abstract Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. …”
Get full text

Evaluation of the Antioxidant and Cytotoxic Activities on Cancer Cell Line of Extracts of Parasitic Plants Harvested in Tunisia by Imen Ben Attia, Paolo Zucca, Flaminia Cesare Marincola, Mariella Nieddu, Alessandra Piras, Antonella Rosa, Antonio Rescigno, Mohamed Chaieb

“…However, in certain areas of the world, they are consumed by humans as food, and they can represent a source of valuable active ingredients of ethnomedical interest. …”
Get full text

Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product by Michael Pino, Karen Mujica, Paola Mora-Uribe, Héctor Garcias-Papayani, Braulio Paillavil, Camilo Avendaño, Diego Flores-Crisosto, Rodrigo Norambuena, Victoria Rojas-Martínez, Matías Aguilera, Nicolás Cifuentes Muñoz, Pablo Cifuentes, Hans Pieringer, Soledad Ulloa

“…Salmonella is a zoonotic pathogen transmitted through food and one of the four leading global causes of diarrheal disease in humans. Brazil is the world's largest exporter of poultry meat, and as such, Brazilian farms routinely detect and prevent Salmonella. …”
Get full text

Stress and Coping Strategies among Students: Review by J.A. Marakshina, V.I. Ismatullina, L.M. Marina

“… <p>Global socio-economic crises, new pandemics, climate disasters, and other large-scale factors create an unfavorable background for humanity, often involving painful processes that lead to significant changes in personality and the social situation of development. …”
Get full text

Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota by Kai Kang, Yue Sun, Dan Pan, Bing Chang, Li-Xuan Sang

“…Vitamin B (nicotinamide (NAM)), one of the most important nutritional components for humans, exerts anti-inflammatory activity. This study was aimed at investigating the effect of NAM on the gut microbiota and short-chain fatty acids (SCFAs) in mice with chronic colitis. …”
Get full text

Increasing exposure of cotton growing areas to compound drought and heat events in a warming climate by Shengli Liu, Wei Zhang, Tongtong Shi, Tong Li, Hui Li, Guanyin Zhou, Zhanbiao Wang, Xiongfeng Ma

“…Cotton (Gossypium hirsutum L.) is a critical source of natural fiber and cottonseed oil for humans, yielding substantial economic benefits globally. …”
Get full text

Prediction of Future Terrorist Activities Using Deep Neural Networks by M. Irfan Uddin, Nazir Zada, Furqan Aziz, Yousaf Saeed, Asim Zeb, Syed Atif Ali Shah, Mahmoud Ahmad Al-Khasawneh, Marwan Mahmoud

“…Terrorism not only disturbs the law and order situations in a society but also affects the quality of lives of humans and makes them suppressed physically and emotionally and deprives them of enjoying life. …”
Get full text

High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome by Tao Hong, Jiao-Yang Li, Ya-Di Wang, Xiao-Yan Qi, Zhe-Zhen Liao, Poonam Bhadel, Li Ran, Jing Yang, Bin Yan, Jiang-Hua Liu, Xin-Hua Xiao

“…This study aimed to investigate serum asprosin levels in MetS as well as their association with various metabolic parameters in humans. Methods. A total of 131 consecutive patients with MetS, and 162 age-matched, healthy subjects were recruited for this study. …”
Get full text

Potential Technosignature from Anomalously Low Deuterium/Hydrogen in Planetary Water Depleted by Nuclear Fusion Technology by David C. Catling, Joshua Krissansen-Totton, Tyler D. Robinson

“…Deuterium–deuterium (DD) fusion is viewed as an ideal energy source for humanity in the far future, given a vast seawater supply of D. …”
Get full text

Occurrence and Exposure Assessment of Zearalenone in the Zhejiang Province, China by Zijie Lu, Ronghua Zhang, Pinggu Wu, Dong Zhao, Jiang Chen, Xiaodong Pan, Jikai Wang, Hexiang Zhang, Xiaojuan Qi, Qin Weng, Shufeng Ye, Biao Zhou

“…This study aims to examine the hazards of zearalenone (ZEN) to humans and assess the risk of dietary exposure to ZEN, particularly in relation to precocious puberty in children from the Zhejiang Province. …”
Get full text

Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. During the same period, 5068 clinical trials were registered in the UMIN-CTR. …”
Get full text

ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation by Marco Túlio R. Gomes, Erika S. Guimarães, Erika S. Guimarães, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira

“…Brucella abortus is the etiologic agent of brucellosis in livestock and humans, leading to significant economic losses and public health impact. …”
Get full text

Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. In vitro biotransformation of tolterodine by HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was investigated by LC-MS analysis of cell culture supernatant for the non-volatile metabolite, N-dealkylated tolterodine, and PTR-ToF-MS analysis of the headspace for acetone. …”
Get full text

The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study by Cheryl R.Z. See, Annabel X. Tan, Lucia R. Valmaggia, Matthew J. Kempton

“…Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal studies investigating the association between stress and changes in brain structure are limited. …”
Get full text

An explorative qualitative study of barriers to the use of health and mental health services among migrant female sex workers in Germany and needs for action by Anastasiia Lotysh, Hürrem Tezcan-Güntekin, Olivia Kalinowski, Gizem Kaya, Franziska Kroehn-Liedtke, Hristiana Mihaylova, Meryam Schouler-Ocak, Wulf Rössler

“…Moreover, needs for actions were identified, which can be used for deriving recommendations for the improvement of healthcare situation of migrant sex workers living in Berlin.Conclusion/discussionHealth services and future intervention studies should consider barriers identified in this study to improve the health services utilization and health of sex workers as part of the effort to protect the right of humans to health.…”
Get full text

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Similarly, serum levels of RDH10 were significantly lower in MASLD and T2DM model mice and humans than in controls.ConclusionOur study suggests that RDH10 is a common diagnostic marker for MASLD and T2DM and provides new research directions for the prevention and treatment of MASLD and T2DM.…”
Get full text

Fuzzy modeling using the similarity-based approximate reasoning system by Jalal Chachi, Mehdi Jalalvand

“…Just as we humans use many different types of inferential procedures to help us understand things or to make decisions,  there are many different fuzzy logic inferential procedures, including similarity-based approaches. …”
Get full text

Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…For EGFR-positive tumor targeting, humanized antigen-binding domains of therapeutic antibody cetuximab were used. …”
Get full text