Skin microbiota: pathogenic roles and implications in atopic dermatitis by Cong Huang, Cong Huang, Fan Zhuo, Fan Zhuo, Yang Guo, Yang Guo, Yang Guo, Siyu Wang, Siyu Wang, Siyu Wang, Siyu Wang, Kaoyuan Zhang, Kaoyuan Zhang, Xiahong Li, Xiahong Li, Wenkui Dai, Xia Dou, Xia Dou, Bo Yu, Bo Yu

Get full text

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.…”
Get full text

Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects by Neil M Davies, Dheeraj Rai, Harriet Forbes, Christina Dalman, Torbjörn Tomson, Daniel Berglind, Michael Lundberg, Cecilia Magnusson, Craig Newschaffer, Brian K Lee, Viktor H Ahlqvist, Paul Madley-Dowd, Christina Dardani, Jessica Rast, Caichen Zhong, Renee M Gardner, Kristen Lyall

Get full text

A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

Get full text

Intelligent task-oriented semantic communications:theory, technology and challenges by Chuanhong LIU, Caili GUO, Yang YANG, Jiujiu CHEN, Meiyi ZHU, Lu’nan SUN

“…Objectives: In the future, intelligent interconnection of all things, such as machine-to-machine and human-to-machine, poses challenges to traditional communication methods. …”
Get full text

Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Purpose: CDK4/6 inhibitors (CDK4/6i) use has revolutionized the treatment of hormone receptor-positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer. …”
Get full text

Design and Validation of Policy Making Model with Open Government Approach by Zahra Mohammadi, Abdolmajid Imani, Farahnaz Ahang

“…Behavioral factors encompass leadership and management styles, human resources management, educational initiatives, and organizational justice practices. …”
Get full text

Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…Additionally, we proposed the pig as a particularly suitable animal model for investigating secondary bile acid production in humans, given its closely aligned secondary bile acid production gene composition. …”
Get full text

Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

“…Methods The hypoxia cell model was established by simulating the cell hypoxic microenvironment in the human SUM159 and MDA-MB-231 cell lines using cobalt II chloride (CoCl2). …”
Get full text

Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Although lopinavir-ritonavir (LPV/r) and darunavir-ritonavir (DRV/r) have shown in vitro efficacy against COVID-19, the results in human studies have been inconsistent. Therefore, our objective was to compare the efficacy of LPV/r and DRV/r in COVID-19 patients admitted to a tertiary centre in Romania.Research design and methodsA clinical dataset from 417 hospitalised patients was analysed. …”
Get full text

Flexible reproductive seasonality in Africa-dwelling papionins is associated with low environmental productivity and high climatic unpredictability by Dezeure, Jules, Dagorrette, Julie, Burtschell, Lugdiwine, Chowdhury, Shahrina, Lukas, Dieter, Swedell, Larissa, Huchard, Elise

“…This study sheds new light on the extent and ecological drivers of flexible reproductive phenology in long-lived tropical mammals, and may even contribute to our understanding of why humans give birth year-round.…”
Get full text

Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study by Camille Windsor, Adrien Joseph, Stephanie Pons, Djamel Mokart, Frederic Pène, Achille Kouatchet, Alexandre Demoule, Fabrice Bruneel, Martine Nyunga, Edith Borcoman, Matthieu Legrand, Michael Darmon, Lara Zafrani, Elie Azoulay, Virginie Lemiale

Get full text

The bronchoalveolar lavage fluid CD44 as a marker for pulmonary fibrosis in diffuse parenchymal lung diseases by Magda Suchankova, Magda Suchankova, Eszter Zsemlye, Eszter Zsemlye, Jan Urban, Peter Baráth, Lenka Kohútová, Barbara Siváková, Barbara Siváková, Martina Ganovska, Elena Tibenska, Kinga Szaboova, Eva Tedlova, Dominik Juskanic, Dominik Juskanic, Kristina Kluckova, Kristina Kluckova, Michaela Kardohelyova, Tetiana Moskalets, Anna Ohradanova-Repic, Patrik Babulic, Maria Bucova, Vladimir Leksa

“…The major hallmark of lung fibrosis is uncontrolled activation of lung fibroblasts to myofibroblasts associated with extracellular matrix deposition and the loss of both lung structure and function.MethodsHere, we used this peculiar feature in order to identify specific biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluids (BALF). The primary MRC-5 human fibroblasts were activated with BALF collected from patients with clinically diagnosed lung fibrosis; the activated fibroblasts were then washed rigorously, and further incubated to allow secretion. …”
Get full text

Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

“…Additionally, the BuOH fraction was non-cytotoxic to human cell-lines. Subsequent FCC and SEC derived subfractions were submitted to the anthelmintic assay workflow and the enriched subfractions B1 and E3.8, phytochemically assigned as 11-β,13-dihydrolactucin and luteolin, demonstrated bioactivity against the embryo phenotype (B1 | 58% ED | c = 1.8 µM and E3.8 | 46% ED | c = 1.7 µM) within range of the flubendazole control. …”
Get full text

Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

Get full text

Surgical options for Evans-Jensen type IV intertrochanteric femur fractures in the elderly over 65: a comparison between total hip arthroplasty and proximal femoral nail antirotati... by Ming Sun, Hai-Rui Liang, He Zhang, Tong Bai, Rong-Da Xu, Si-Yu Duan, Zhen-Cun Cai, Zhen-Cun Cai

Get full text

Rapid identification and phenotyping of nonalcoholic fatty liver disease patients using a machine‐based approach in diverse healthcare systems by Anna O. Basile, Anurag Verma, Leigh Anne Tang, Marina Serper, Andrew Scanga, Ava Farrell, Brittney Destin, Rotonya M. Carr, Anuli Anyanwu‐Ofili, Gunaretnam Rajagopal, Abraham Krikhely, Marc Bessler, Muredach P. Reilly, Marylyn D. Ritchie, Nicholas P. Tatonetti, Julia Wattacheril

Get full text

Arbuscular mycorrhizal fungi mitigate cadmium stress in maize by Qiqiang Kuang, Yujie Wu, Yamin Gao, Tingting An, Shuo Liu, Liyan Liang, Bingcheng Xu, Suiqi Zhang, Min Yu, Sergey Shabala, Yinglong Chen

“…Soil cadmium (Cd) pollution poses a significant environmental threat, impacting global food security and human health. Recent studies have highlighted the potential of arbuscular mycorrhizal (AM) fungi to protect crops from various heavy metal stresses, including Cd toxicity. …”
Get full text

Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Heavy metals in various geochemical forms, such as exchangeable ions, carbonates, and oxides, pose significant risks to human health and the environment due to their persistence and bioaccumulation. …”
Get full text

A Systematic Review on Poisoned Patients as Potential Organ Donors by Kattamreddy Ananth Rupesh, Anirudh Suseel Nalumaru, Mohit Kumar Moses Thathapudi, Omkarnath Sivarchaka, Deekshitha Alla

“…Studies lacking patient data or involving non-human research were excluded. To assess the risk of bias and quality of the included studies, the Joanna Briggs Institute Critical Appraisal Checklists and the Newcastle-Ottawa Scale were used. …”
Get full text