Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells by Chih-Hsin Lin, JenHer Lu, Hsinyu Lee

“…Interleukin- (IL-) 1β, a proinflammatory cytokine, is elevated upon LPA treatment in human umbilical vein endothelial cells (HUVECs). …”
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Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…We aimed to prepare non-targeted oxaliplatin-loaded chitosan nanoparticles (OXPT-CS NPs) and targetedOXPT-CS NPs decorated with cetuximab single-chain variable fragment (scFv) to send both NPs to epidermal growth factorreceptor (EGFR) overexpressing HCT 116 cells, a human colorectal carcinoma cell line, for comparing their cytotoxicity.Materials and Methods: In this experimental study, OXPT-CS NPs were synthesized using a fluid system. …”
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The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks by Benoît Chénais, Vincent Blanckaert

“…For several years, lipids and especially 𝑛−3 and 𝑛−6 polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. …”
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Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research by Robby Mathew Zachariah, Mojgan Rastegar

“…Epigenetics play key roles in development and cell fate commitments and highly impact the etiology of many human diseases. A well-known link between epigenetics and human disease is the X-linked MECP2 gene, mutations in which lead to the neurological disorder, Rett Syndrome. …”
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Intensional profiles and different kinds of human minds. “Case studies” about Hungarian imperative-like sentence types by Gábor Alberti, Judit Kleiber, Zsuzsanna Schnell, Veronika Szabó

“…This latter subproject is relevant since our framework provides solutions to pragmaticosemantic phenomena “at the cost” of undertaking the complex task of actually representing the structure of the human mind itself – which is not impossible but requires an adequate decision of the level of abstraction and the components to be used. …”
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Evidence of human exposure and associated risk factors to Rift Valley fever in selected districts of Central and Western Zambia. by Chilufya C Kasongamulilo, Michelo Syakalima, Ngondo Saasa, Henson Kainga, Girja S Pandey, Andrew N Mukubesa, Innocent Mwape, Masahiro Kajihara, Ayato Takada, Martin Simuunza

“…Rift Valley fever (RVF) is an important viral zoonotic disease that not only affects ruminants but causes serious morbidity and mortality in humans. In humans, its symptoms range from mild flu-like signs to a severe form such as retinal damage, meningoencephalitis to haemorrhagic fever. …”
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Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure by Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao Li

“…Human umbilical cord-derived mesenchymal stem cells (UCMSCs) are particularly attractive cells for cellular and gene therapy in acute liver failure (ALF). …”
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Market Solution to Environmental Tragedy with Coasean Bargaining, Commons in the Form of Common Property, and International Human Rights Law by Aljosa Noga

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Increased PPARD Expression May Play a Protective Role in Human Lung Adenocarcinoma and Squamous Cell Carcinoma by Yong Zhu, Yedong Mi, Zhonghua Qin, Xuewei Jiang, Yibo Shan, Kamil Kural, Guiping Yu

“…Peroxisome proliferator-activated receptor-δ, encoded by gene PPARD, is overexpressed in a majority of human lung cancer subtypes, but its role in the tumor progression remains poorly understood. …”
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CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling by Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang

“…Its effect on osteogenic differentiation of human dental follicle cells (hDFCs) remains unclear. …”
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Effect of Common Buffers and Heterocyclic Ligands on the Binding of Cu(II) at the Multimetal Binding Site in Human Serum Albumin by Magdalena Sokołowska, Krystyna Pawlas, Wojciech Bal

“…Visible-range circular dichroism titrations were used to study Cu(II) binding properties of Multimetal Binding Site (MBS) of Human Serum Albumin (HSA). The formation of ternary MBS-Cu(II)-Buffer complexes at pH 7.4 was positively verified for sodium phosphate, Tris, and Hepes, the three most common biochemical buffers. …”
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Candidate SNP markers of social dominance, which may affect the affinity of the TATAbinding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…The proposed hypothesis, the candidate SNP markers predicted and the observed regularities of effects of natural selection for the human genome are discussed in comparison with published data: whether they can have any relation to social dominance in human. …”
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Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus by Ilaria Bononi, Elisa Mazzoni, Silvia Pietrobon, Maria Rosa Iaquinta, Andrea Caselli, Elena Torreggiani, Maura Pugliatti, Ilaria Casetta, Massimiliano Castellazzi, Enrico Granieri, Fernanda Martini, Mauro Tognon

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Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

“…To further confirm our findings, we investigated the clinicopathologic significance of TLR4 and CXCR7 expression using immumohistochemistry in 135 human PTC tissues and 56 normal thyroid tissue samples. …”
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Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa by Evans Aboagye, Francis Agyemang-Yeboah, Babatunde Moses Duduyemi, Christian Obirikorang

“…Fewer studies have been done over the years to establish the association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSSC) within the subregions of sub-Saharan Africa, and thus this study was designed to investigate the presence of HPV in HNSCC at a tertiary hospital in Ghana, providing additional evidence on the need to explore similar studies in other subregions. …”
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Non-stationarity analysis of flood extremes under climate change and human activities in the Yuan River Basin, China by Ting Wang, Dehua Mao, Meirong Deng, Chang Feng, Guangwei Hu, Jingya Zhang, Yang Zou

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Spatial Analysis of Human Health Risk Associated with Trihalomethanes in Drinking Water: A Case Study of Karachi, Pakistan by Zahida Karim, Bilal Aslam Qureshi, Ishtiaq Ghouri

“…Lifetime cancer risk and hazard index of THMs through oral ingestion and dermal absorption were calculated and mapped using kriging as an interpolation method to evaluate the carcinogenic and noncarcinogenic risk to human health in the study area. Lifetime cancer risk value due to the oral ingestion of TTHMs in different towns of the city was exceeded from 1.0×10−6, showing that residents of these towns were expected to be at higher cancer risk. …”
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miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells by Virginie Joris, Elizabeth R. Balmayor, Martijn van Griensven

“…Among them, miR-125b is well known to enhance osteoporosis and reduce osteogenic differentiation of human mesenchymal stem cells (hMSCs). In this work, we aim to evaluate and understand how miR-125b modulates mineralization of hMSCs in two different in vitro models. …”
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Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening by Yu-hong Wang, Ting-ting Liu, Yan-ping Guo, Shuo-ji Zhu, Zi-ming Liao, Jia-mei Song, Xi-ming Zhu, Jia-liang Liang, Moussa Ide Nasser, Nan-bo Liu, De-hua Chang, Ping Zhu, Bin Yao

“…The preclinical evaluation of drug-induced cardiotoxicity is critical for developing novel drug, helping to avoid drug wastage and post-marketing withdrawal. Although human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and the engineered heart organoid have been used for drug screening and mimicking disease models, they are always limited by the immaturity and lack of functionality of the cardiomyocytes. …”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. …”
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