Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

“…Furthermore, the Lands cycle acyl-transferases that catalyze their formation are unidentified. eoxPL were measured in platelets and leukocytes from an atherosclerotic cardiovascular disease (ASCVD) cohort and retrieved human arterial thrombi from three anatomical sites. …”
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Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

“…Abstract Returning to the moon and traveling to Mars represent the main targets of human space exploration missions within the upcoming decades. …”
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The physiological responses to volume-matched high-intensity functional training protocols with varied time domains by Jessica S. Smith, Jessica S. Smith, Gabriella F. Bellissimo, Gabriella F. Bellissimo, Fabiano T. Amorim

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Prevalence and determinants of HIV among reproductive-age women (15–49 years) in Africa from 2010 to 2019: a multilevel analysis of demographic and health survey data by Alemu Gedefie, Amare Muche, Anissa Mohammed, Aznamariam Ayres, Dagnachew Melak, Eyob Tilahun Abeje, Fekade Demeke Bayou, Fekadeselassie Belege Getaneh, Lakew Asmare, Abel Endawkie

“…BackgroundHuman immunodeficiency virus (HIV) remains the leading cause of global morbidity and mortality. …”
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Job burnout and resilience among palliative care professionals in china: a qualitative study by Fang Tan, Yan Wu, Na Li, Chuan Zhang, Shan Chen, Lan Huang, Yang Chen, Jianjun Jiang, Qian Deng

“…Promoting the construction of a professional team in palliative medicine, rational allocation of human resources, improving the welfare benefits of professionals, enhancing their social status, safeguarding their legitimate rights and interests, establishing effective emotional and social support systems, and implementing effective intervention measures in cultural contexts are all effective ways to reduce work fatigue and enhance resilience. …”
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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer by Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Ali Darehkordi, Alireza Najafi, Milad Karimi, Majid Khoshmirsafa, Gholamhossein Hassanshahi, Elaheh Safari, Reza Falak

“…Further validation through rigorous preclinical and clinical studies may position A1 as a promising alternative to AMD3100 in human cancers.…”
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Strategies for Customer Relationship Management Focused on Loyalty by J. Vasco, C. Guerra, F. Favicela, X. Granizo

“…A formal methodology was described for developing and implementing a CRM system that integrates aspects such as defining a customer strategy, re-engineering customer-oriented business processes, human resources management, the computer system, and management of change and continuous improvement. …”
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Chinese burden of depressive disorders from 1990 to 2021 and prediction for 2030: analysis of data from the global burden of disease study 2021 by Na Yan, Caochen Zhang, Yihan Wang, Yuhao Wang, Yunjiao Luo, Yingxue Wang, Blen Dereje Shiferaw, Louisa Esi Mackay, Jingjing Wang, Jie Tang, Qingzhi Wang, Xiuyin Gao, Wei Wang

“…Considering the large population, the increasing fewer children, and the aging trend, as well as the possible long-term effects of COVID-19 on human psychological burden, more sex-age-sensitive social healthcare programs should be considered in the future to minimize the burden of depressive disorders in China.…”
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Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway by Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei

“…Our study intended to prove whether agonistic autoantibodies to angiotensin II type 1 receptor (AT1-AAs) exist in patients with coronary heart disease (CHD) and affect the human endothelial cell (HEC) by upregulating proinflammatory cytokines expression involved in NF-κB pathway. …”
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Fabrication of Nano-Silver Composite Using Amomum longiligulare Fruit Polysaccharides and Their Biological Activities by Lian Y, Ma N, Cheng Q, Luo M, Xu Z, He F, Zhou X, Zhang Y, Jin D, Kong Y, Wang Y, Wei N

“…Yong Lian,1,* Ning Ma,2,* Qianying Cheng,1,* Mingquan Luo,1 Zhen Xu,1 Fei He,1 Xiaomei Zhou,1 Ying Zhang,1 Dejun Jin,1 Yidan Kong,1 Yong Wang,1 Na Wei1 1Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China; 2Reproductive Medical Center, Hainan Women and Children’s Medical Center, Haikou, Hainan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Na Wei; Yong Wang, Hainan Provincial Key Laboratory of R&D on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China, Email weina-0613@163.com; wangyong1982_2004@163.comPurpose: Study aims to optimize the synthesis conditions for silver nanoparticle composites [ALP(D)-AgNPs] using a rapid and environmentally friendly method and investigate the antioxidant, antibacterial, and anticancer activities of the fabricated composite.Methods: The polysaccharide component ALP-D was extracted and purified from the fruits of Amomum longiligulare and subsequently used for further experiments. …”
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Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis by Xiaofang Liu, Bin Li, Yuxi Lin, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Xia Wang, Nanjing Li, Xiaoyun Liu, Xiaohong Chen

“…Finally, the biomarkers’ expression was validated in human and mice experiments.ResultsSeveral shared genes among MS, SLE, and RA were identified, which play crucial roles in immune responses and inflammation regulation. …”
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Effects of a 10-week athletic performance program on match performance variables in male professional football players by Sergio Jiménez Rubio, José L. Estévez Rodríguez, Victor Escamilla Galindo, Sergio L. Jiménez-Sáiz, Juan Del Coso

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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation by Ting Shen, Jing Yu, Bin Xie, Cuiping Huang, Jingjie Cui, Kefu Liu, Chunyu Liu, Chao Chen

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Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle by Giorgia Di Muro, Carlotta Tessarolo, Giulia Cagnotti, Alessandra Favole, Sara Ferrini, Ugo Ala, Claudio Bellino, Giuliano Borriello, Marina Gallo, Giulia Iamone, Barbara Iulini, Marzia Pezzolato, Cristina Casalone, Maria Caramelli, Lorenzo Capucci, Patrizia Cavadini, Cristiano Corona, Antonio D’Angelo

“…Abstract Neurofilament light chain (Nf-L) is a biomarker for axonal damage in human neurology but is understudied in cattle. With this study we wanted to determine Nf-L stability at two different storage temperatures and Nf-L levels in healthy cattle and the relationship with age, evaluate whether Nf-L holds diagnostic potential for neurological disorders, and whether an association exists between Nf-L in serum and in cerebrospinal fluid (CSF). …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…However, its specific pathological significance in humans is not well understood. Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a well-established primate model of MS. …”
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Innovative CO2-NBs-assisted ultrasonication for the phytochemical extraction of peanut (Arachis hypoga) shells: Synthesis and characterization of CO2-nanobubbles by Nayyar Iqbal, Miral Javed, Ramy M. Khoder, Areej Areej, Renyu Zheng, Shanbai Xiong, Ibrahim Khalifa, Hassan Barakat, Youming Liu

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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Methods Gene expression profiling interactive analysis (GEPIA), human protein atlas (HPA), cBioPortal, Kaplan–Meier (KM) plotter, single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm and SubMap algorithms were utilized to analyze the role of ELOVLs in the LUAD. …”
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Species-specific mercury speciation in billfishes and its implications for food safety monitoring and dietary advice by Anaïs Médieu, David Point, Valérie Allain, Nathalie Bodin, Mélanie Lemire, Pierre Ayotte, Zahirah Dhurmeea, Matthieu Waeles, Laure Laffont, Antoine Le Gohalen, François Roupsard, Anne Lorrain

“…Humans are exposed to toxic methylmercury mainly by consuming marine fish, in particular top predator species like billfishes or tunas. …”
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Identifikasi Tanaman Obat Indonesia Melalui Citra Daun Menggunakan Metode Convolutional Neural Network (CNN) by Budi Setiyono, Muhammad Riv’an Arif, Qonita Qurratu Aini, Theophil Henry Soegianto, Jasti Ohanna, Ricky Andrean Fernanda Gunawan, Ayu Putri Rizkia

“…Indonesian people have used plants as traditional medicine since ancient times. At this time, human knowledge in recognizing the types of medicinal plants is decreasing due to humans' limited memory. …”
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Ganciclovir Resistance-Linked Mutations in the HCMV <i>UL97</i> Gene: Sanger Sequencing Analysis in Samples from Transplant Recipients at a Tertiary Hospital in Southern Brazil by Anna Caroline Avila da Rocha, Grazielle Motta Rodrigues, Alessandra Helena da Silva Hellwig, Dariane Castro Pereira, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Fernanda de-Paris

“…<b>Background/Objectives:</b> Human cytomegalovirus (HCMV) DNAemia remains a significant concern for transplant recipients, largely due to mutations in the viral genome that may lead to antiviral-resistant strains. …”
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