A novel CFD-MILP-ANN approach for optimizing sensor placement, number, and source localization in large-scale gas dispersion from unknown locations by Yiming Lang, Michelle Xin Yi Ng, Kai Xiang Yu, Binghui Chen, Peng Chee Tan, Khang Wei Tan, Weng Hoong Lam, Parthiban Siwayanan, Kek Seong Kim, Thomas Shean Yaw Choong, Joon Yoon Ten, Zhen Hong Ban

“…Illegal practices like open electronic waste incineration release hazardous pollutants, endangering the environment and human health. The Internet of Things (IoT) enables online real-time gas concentrations, but its capability to predict leak sources accurately remains a challenge. …”
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Predicting the risk of high-grade precancerous cervical lesions based on high-risk HPV typing in Changsha China by Yaling Xiao, Rangjiao Liu, Shaobo Wang, Yuxiang Wang, Weimin Miao, Meiwei Chen, Xiaowen Liu, Yan Chen, Yongchun Wen, Zhongping Deng, Lizhong Dai, Zenghui Mao, Jun He

“…Abstract Background Persistent infection with high-risk human papillomavirus (HPV) is a significant risk factor for cervical cancer. …”
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Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics by Andong Guo, Andong Guo, Chenrui Wu, Jishuang Cao, Kejia Zhu, Kejia Zhu, Sentai Ding, Sentai Ding

“…ObjectiveThis study aimed to explore the clinical relevance of Human Epidermal Growth Factor Receptor 2 (HER2) in urothelial carcinoma (UC) and its association with glycolytic metabolic markers, insulin resistance, and beta-cell function, shedding light on potential therapies targeting both HER2 pathways and cancer metabolism.MethodsIn this retrospective analysis, 237 UC patients from the Departments of Urology and Pathology at Shandong Provincial Hospital were examined. …”
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Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic arsenic exposure on prostate cancer metastasis still unclear. …”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…Immunofluorescence assay was employed to measure the expression of p-eIF2α, ATF4 and CHOP in the ovarian tissue. After steroidogenic human granulosa-like tumor cell line KGN were exposed to 100 μmol/L DHEA to simulate the hyperandrogen environment of PCOS, and then treated with 5 and 10 μg/mL AS for 24 h, the protein levels of endoplasmic reticulum stress signaling pathway was detected by Western blotting. …”
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Proteomic Analysis of MCF-7 Breast Cancer Cell Line Exposed To Leptin by A. Valle, J. Sastre-Serra, C. Pol, A. M. Miró, J. Oliver, P. Roca

“…To contribute to the understanding of the molecular mechanisms underlying leptin action in breast cancer, our aim was to identify proteins regulated by leptin in MCF-7 human breast cancer cells. Methods: We used two-dimensional gel electrophoresis (2-DE) and matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) to identify proteins affected by leptin. …”
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A Sustainable Approach: Repurposing Red Beetroot Peels for Innovative Meringue Products by Oana Emilia Constantin, Florina Stoica, Silvia Lazăr (Mistrianu), Doina Georgeta Andronoiu, Mihaela Turturică, Nicoleta Stănciuc, Roxana Nicoleta Rațu, Constantin Croitoru, Gabriela Râpeanu

“…The research findings indicate that BP has the potential to be used as a natural food ingredient to promote human health, resource-use efficiency, and a circular economy.…”
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DsTau: study of tau neutrino production with 400 GeV protons from the CERN-SPS by The DsTau collaboration, Shigeki Aoki, Akitaka Ariga, Tomoko Ariga, Sergey Dmitrievsky, Elena Firu, Dean Forshaw, Tsutomu Fukuda, Yuri Gornushkin, Ali Murat Guler, Maria Haiduc, Koichi Kodama, Masahiro Komatsu, Muhtesem Akif Korkmaz, Umut Kose, Madalina Miloi, Antonio Miucci, Motoaki Miyanishi, Mitsuhiro Nakamura, Toshiyuki Nakano, Alina Neagu, Hiroki Rokujo, Osamu Sato, Elizaveta Sitnikova, Yosuke Suzuki, Tomoki Takao, Svetlana Vasina, Mykhailo Vladymyrov, Thomas Weston, Junya Yoshida, Masahiro Yoshimoto

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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…To this aim, we took advantage of immunodeficient mice reconstituted with a human immune system (HuSGM3) and engrafted with the B-cell acute lymphoblastic leukemia cell line NALM-6, a model that allows to thoroughly study efficacy and toxicity profiles of CD19 CAR-T cell products.Results CD4 CAR-T cells showed superior proliferation and activation potential, which translated into stronger stimulation of myeloid cells, the main triggers of adverse events. …”
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Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining by Kristian Kjærgaard, Chris H. Dreyer, Nicholas Ditzel, Christina M. Andreasen, Li Chen, Søren P. Sheikh, Søren Overgaard, Ming Ding

“…Origin of new bone was assessed using human vimentin (HVIM) antibody staining. Results. …”
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Concurrent severe fever with thrombocytopenia syndrome virus outbreaks on multiple fox farms, China, 2023 by Jian Sun, Lei Qian, Delong Li, Xiurong Wang, Hong Zhou, Cixiu Li, Edward C. Holmes, Jianke Wang, Juan Li, Weifeng Shi

“…The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic fox (Vulpes lagopus) farms in Shandong and Liaoning provinces, China, which lasted for 2–3 months and resulted in tens to hundreds of fatalities per farm. …”
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Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections by Sambit Tarai, Elin Lundström, Nouman Ahmad, Robin Strand, Håkan Ahlström, Joel Kullberg

“…One significant challenge is the risk for human error, leading to potential omission of especially small tumors and tumors with low FDG uptake.Purpose: In this study, we introduced an automated framework with segmentation prior, from a tissue-wise multi-channel multi-angled based approach, to enhance tumor segmentation in whole-body FDG-PET/CT.Method: The proposed framework utilized a segmentation prior generated from tumor segmentations in tissue-wise multi-channel projections of the standardized uptake value (SUV) from PET. …”
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Photothermal performance of nanofluids: An experimental study on direct absorption solar energy conversion using graphene oxide and its binary composites for water purification by Abdul Sattar, Bai Bofeng, M. Adeel Munir, Muhammad Farooq, S. Bilal, M. Imran Khan, Noreen Sher Akbar, Mohammed Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Water scarcity affects two-thirds of the world’s population and is one of the most important challenges to human development. Nanotechnology led by solar evaporation is emerging to solve water resource problems by absorbing solar energy to vaporize nanofluid samples, especially in areas where seawater resources are abundant and economical. …”
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Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study by Ruei-Hong Li, Tai-Rui Chen, Nicholas D. Gilson, Marius Brazaitis, Yi-Ting Cheng, Hui-Fang Wu, Ji-Hang Lee, Yu-Kai Chang

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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

“…Descriptive analyses and multilevel models will be used to examine QOL across groups and to investigate potential explanatory variables.Ethics and Dissemination Approval has been obtained from all relevant Human Research Ethics Committees (HRECs), including the Sydney Children’s Hospitals Network and the Royal Children’s Hospital Melbourne HRECs. …”
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PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…Results Here, we revealed that PTOV1 was highly expressed in human CRC tissues, especially at advanced stages, and associated with reduced survival time among CRC patients. …”
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Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance by Xiaoqin Cao, Shuzheng Liu, Manman Jia, Hongmin Chen, Dongmei Zhao, Bing Dong, Zhen Guo, Lingyan Ren, Shaokai Zhang, Xibin Sun

“…Context. Human papillomavirus (HPV) testing is widely used in cervical cancer screening in women; however, its efficiency in triaging women with atypical squamous cells of undetermined significance (ASC-US) needs to be validated. …”
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Artificial-Intelligence-Based Investigation on Land Use and Land Cover (LULC) Changes in Response to Population Growth in South Punjab, Pakistan by Tanweer Abbas, Muhammad Shoaib, Raffaele Albano, Muhammad Azhar Inam Baig, Irfan Ali, Hafiz Umar Farid, Muhammad Usman Ali

“…Land use and land cover (LULC) changes are significantly impacting the natural environment. Human activities and population growth are negatively impacting the natural environment. …”
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Brain development using a multicomponent intravenous lipid emulsion in preterm infants by Katherine M. Ottolini, Julius Ngwa, Sudeepta K. Basu, Kushal Kapse, Melissa Liggett, Jonathan Murnick, Catherine Limperopoulos, Nickie Andescavage

“…The primary aim of this study was to assess extrauterine third trimester brain growth in very preterm infants supported with soybean oil-only compared to fish-oil containing multicomponent lipid emulsions; white matter development and neurobehavioral regulation at term were also investigated. Methods Human milk-fed very preterm infants (born less than or equal to 32 weeks’ gestation) receiving either soybean oil-only (before 2019) or multicomponent (after 2019) lipid emulsions underwent quantitative brain MRI (volumetric growth and white matter development) and neurodevelopmental assessment (Neonatal Intensive Care Unit Network Neurobehavioral Scale) at term-equivalent age. …”
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