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27861
Widespread use of ChatGPT and other Artificial Intelligence tools among medical students in Uganda: A cross-sectional study.
Published 2025-01-01“…<h4>Background</h4>Chat Generative Pre-trained Transformer (ChatGPT) is a 175-billion-parameter natural language processing model that uses deep learning algorithms trained on vast amounts of data to generate human-like texts such as essays. Consequently, it has introduced new challenges and threats to medical education. …”
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27862
Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis
Published 2025-02-01“…While higher doses and longer treatments appear beneficial, further research, particularly human clinical trials, is necessary to verify its effectiveness and safety in people.…”
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27863
Construction and function validation of inducible immortalized gene integration vectors
Published 2024-12-01“…[Methods] Using gene homologous recombination technology, the coding sequences (CDS) of immortalization genes-including human telomerase reverse transcriptase (hTERT), simian virus 40 large T antigen (SV40LT), acute myeloid leukemia fusion genes NUP98-KDM5A (N/K) and CBFA2T3-GLIS2 (C/G), as well as the proto-oncogene KRAS were precisely inserted into the tetracycline (Tet)-inducible eukaryotic expression lentiviral vector pLV2-TRE3GS-EGFP-MCS-3×FLAG-hPGK-Tet-On-SV40-Neo and the transposon PB-TRE3G-3×FLAG-T2A-Puro-SV40-PA. …”
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27864
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27865
Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer
Published 2025-01-01“…These drug candidates were further characterized to predict their biological activity spectra in the human body and medicinal characteristics to know their extensive behavior in laboratory testing. …”
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27866
Double degree programs and education for sustainable development implementation: Experience of Ukrainian and UK universities cooperation in wartime
Published 2025-02-01“…Ukrainian HEIs have been significantly losing their capacity for development. Loss of human capital, including educational losses, becomes more relevant from the perspective of further sector development.This paper explores the intersection of DDP implementation and the implementation of Education for Sustainable Development (ESD), focusing on faculty members’ experiences within the Twinning Initiative framework. …”
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27867
USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression
Published 2025-01-01“…Deubiquitylating enzymes (DUBs) emerge as novel therapeutic targets against human cancers. However, the nucleolar phase separation of DUBs and association with lung cancer development have remained incompletely investigated till now. …”
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27868
Penyeimbangan Kelas SMOTE dan Seleksi Fitur Ensemble Filter pada Support Vector Machine untuk Klasifikasi Penyakit Liver
Published 2023-12-01“…Abstract The liver is one of the important organs in the human body that plays a role in the body's metabolic processes. …”
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27869
Syrian refugee and diaspora healthcare professionals: Case studies from the eastern mediterranean and European regions
Published 2025-01-01“…Initially, many stayed in the eastern mediterranean region; however, as the conflict became increasingly protracted and employment policies for Healthcare Professionals (HCPs) became increasingly restrictive, some moved elsewhere, particularly to Germany and the United Kingdom, both of which have aimed to capitalise on both refugee and diaspora HCPs to support human resources gaps in their health systems. Our aim is to explore the different policy practices towards Syrian refugee and diaspora HCPs in the eastern mediterranean and European regions. …”
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27870
Patient centered medication treatment for opioid use disorder in rural Vermont: a qualitative study
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27871
THE ROLE OF MUNICIPAL LEGAL AWARENESS AND MUNICIPAL PSYCHOLOGY IN THE PROCESSES OF FORMING THE GLOBALIST POTENTIAL OF THE TERRITORIAL COMMUNITY
Published 2022-06-01“…Considering the functional purpose of municipal legal consciousness through the disclosure of its functions, the author emphasizes the evolutionary features of the formation of such a form of legal consciousness, which are in the preserved traditions of municipal development and achieved innovations in municipal construction, and also, taking into account their typicality for all human communities, significantly influence the formation their globalist potential.…”
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27872
JAUNOSIOS KARTOS KATALIKŲ INTELEKTUALŲ POŽIŪRIS Į FAŠIZMĄ IR NACIONALSOCIALIZMĄ TARPUKARIO LIETUVOJE
Published 2001-01-01“…It was also at variance with the doctrine of Catholic Church, because the state of Nazi "nationalized" the natural human rights and freedoms by assuming the right to determine the conditions and limits of a self-expression of an individual and simultaneously to dispose completely the spiritual life of the individual. …”
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27873
Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD
Published 2017-03-01“…In a proof‐of‐concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment.…”
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27874
High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches
Published 2025-01-01“…Abstract Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage renal disease, thus seriously threatens human health. However, current medications for CKD and fibrosis are inefficient, which is often due to poor targeting capability to renal tubule. …”
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27875
Conservation education for sustainable development through field internship at NGOs
Published 2025-01-01“…Non-governmental organizations organizing and presenting field internship program can significantly lower the barriers that impede many youth members to take the critical step, and they can play a significant role in inter-sectoral collaboration in human resource development. We discuss the role of conservation organizations in mobilizing youth as agents of change for sustainable futures, both through their own activities and in collaborations with private sector and academia.…”
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27876
Consequences of insecticide overuse in Hungary: assessment of pyrethroid resistance in Culex pipiens and Aedes albopictus mosquitoes
Published 2025-01-01“…Abstract Background Mosquitoes, as vectors of various pathogens, have been a public health risk for centuries. Human activities such as international travel and trade, along with climate change, have facilitated the spread of invasive mosquitoes and novel pathogens across Europe, increasing the risk of mosquito-borne disease introduction and their spread. …”
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27877
Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes
Published 2025-01-01“…<b>Methods</b>: The interactions of pinocembrin on drug transporters were determined in the Madin–Darby canine kidney (MDCK) cells overexpressing human (h)OAT1 or hOAT3 and in the Chinese hamster ovary (CHO-K1) cells overexpressing hOCT1, hOCT2, hMATE1, or hMATE2. …”
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27878
Prevalence, cessation, and geographical variation of smoking among middle-aged and elderly adults in China: A population-based study
Published 2024-07-01“…Introduction Smoking significantly burdens human health, contributing to an increasing incidence of mortality and morbidity. …”
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27879
Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts
Published 2025-02-01“…Significance: Plantar warts, benign lesions on the soles of the feet, are caused by the human papillomavirus (HPV) infecting keratinocytes. …”
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27880
Early Changes in [18F]FDG Uptake as a Readout for PI3K/Akt/mTOR Targeted Drugs in HER-2-Positive Cancer Xenografts
Published 2021-01-01“…CD-1 nude mice were inoculated with HER-2-overexpressing JIMT1 (trastuzumab-resistant) or SKOV3 (trastuzumab-sensitive) human cancer cells. Animals were treated with trastuzumab, everolimus (mTOR inhibitor), PIK90 (PI3K inhibitor), saline, or combination therapy. [18F]FDG scans were performed at baseline, two, and seven days after the start of the therapy. …”
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