Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…Conclusion: Long-term MC exposure disrupts liver function and induces oxidative stress in cattle, implicating significant risks for both animal and human health. The bioaccumulation of cyanotoxins in livestock emphasizes the urgent need for preventive measures, including water monitoring, restricted livestock access to contaminated sites, and farmer education. …”
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Spectrum and trends of cancer among HIV patients in Southwestern Uganda. by Raymond Atwine, Mitala Yekosani, Abraham Birungi, Brian Ssenkumba, Barbra Tuhamize, Richard Ezinga, Keneth Male, Taseera Kabanda

“…The study was aimed at studying the changing spectrum and trends of cancer among Human Immunodeficiency Virus (HIV) patients in southwestern Uganda.…”
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Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients by Raffaele Pezzani, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Sara Watutantrige-Fernando, Gianmaria Pennelli, Francesca Galuppini, Susi Barollo, Caterina Mian

“…Seventy-one sporadic MTC human samples were analyzed for RET mutations and by qPCR for PTTG1 and AURKA (Aurora kinase A) expression. …”
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Noninvasive Detection of Alpha-Amylase in Saliva Using Screen-Printed Carbon Electrodes: A Promising Biomarker for Clinical Oral Diagnostics by Reviansyah FH, Ristin AD, Rauf AA, Sepirasari PD, Alim FN, Nur Y, Takarini V, Yusuf M, Aripin D, Susilawati S, Komariah M, Alam BYCSSS

“…Faris Hernando Reviansyah,1,* Azzahra Delvyra Ristin,1,* Adil Abdul Rauf,2 Prisilia Dita Sepirasari,2 Fahmi Nur Alim,2 Yuspian Nur,3 Veni Takarini,4 Muhammad Yusuf,5 Dudi Aripin,6 Sri Susilawati,7 Maria Komariah,8 Boy Yoseph Cahya Sunan Sakti Syah Alam9 1Undergraduate Program, Faculty of Dentistry, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 2Undergraduate Program, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 3Laboratory of Research and Development of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, 75119, Indonesia; 4Department of Dental Materials and Technology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, 40132, Indonesia; 5Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 6Department of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, 40132, Indonesia; 7Department of Dental Public Health, Faculty of Dentistry, Universitas Padjadjaran, Bandung, 40132, Indonesia; 8Department of Fundamental Nursing, Faculty of Nursing, Padjadjaran University, Bandung, 40132, Indonesia; 9Faculty of Geological Engineering, Universitas Padjadjaran, Jatinangor, Jawa Barat, 45363, Indonesia*These authors contributed equally to this workCorrespondence: Faris Hernando Reviansyah, Email faris21001@mail.unpad.ac.idBackground: Biomarkers are essential tools for diagnosing diseases. Saliva, as a human fluid, effectively reflects the body’s condition due to its rich composition. …”
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Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study by Zucca G, Vigani B, Valentino C, Ruggeri M, Marchesi N, Pascale A, Giovilli G, Malavasi L, Sandri G, Rossi S

“…Cytotoxicity and internalization were assessed in vitro using Human Umbilical Vein Endothelial Cells (HUVEC). The NAR/β-CD complex was prepared and evaluated for morphology, complexation efficiency, and solubility. …”
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En plaque meningioma of the temporal bone: A systematic review on the imaging and management of a rare tumor by Arianna Burato, Giuseppe Maruccio, Livio Presutti, Ignacio Javier Fernandez, Gabriele Molteni, Giulia Molinari

“…Inclusion criteria were articles of human patients affected by TB-MEP; English or Italian language; availability of the abstract articles unrelated to TB-MEP, guidelines and systematic reviews were excluded. …”
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Influence of bottled salad dressings on the development of enamel erosion in the presence or absence of salivary pellicle – An in vitro study by Aishwarya Lakshmi Billa, Jagadeeswara Rao Sukhabogi, Dolar Doshi, Prashant Sharma, T.V.S. Subrahmanyam, Sasikala Jummala

“…Eighty tooth specimens (measuring 4 × 4 × 3 mm) were prepared from extracted human premolars and randomly assigned to four groups (group 1: orange juice; group 2: eggless plain mayonnaise; group 3: sandwich spread; and group 4: thousand island dressing) with 20 samples in each group. …”
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Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

“…The review summarises recent findings and provides an update of the current understanding of thyroid dysfunction in COVID-19-related spectrum of disorders, underscoring the complex nature of SARS-CoV-2 infection and its far-reaching impacts on human health.…”
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Future of artificial intelligence for the diagnosis and treatment of retinal diseases by E.A. Katalevskaya, D.Yu. Katalevskiy, M.I. Tyurikov, I.A. Velieva, A.V. Bol’shunov

“…Alekseev, Nizhny Novgorod,&nbsp;</b><b>Russian Federation</b> </p> <p> <b>⁴Scientific Research Institute of Eye Diseases, Moscow, Russian Federation</b> </p> <p> <i>Artificial intelligence (AI) is a branch of informatics concerned with developing programs capable of imitating certain functions of the human mind. AI technologies are applied in different areas of medicine, including ophthalmology. …”
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Plastome data provides new insights into population differentiation and evolution of Ginkgo in the Sichuan Basin of China by Liyun Nie, Fangling Liu, Meixia Wang, Zhuying Jiang, Jiali Kong, Luke R. Tembrock, Shenglong Kan, Penghao Wang, Jie Wang, Zhiqiang Wu, Xiaoli Liu

“…Ancient trees (314–784 years) provided evidence for interaction between natural processes and historical human dispersal in shaping current genetic patterns. …”
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Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds by K. Grimm, A. Fiedler, C. Kröger

“…Commonly used hoof care products such as formalin or copper sulfate applied through foot baths or by spraying hindfeet are often irritant to the skin as well as harmful to the environment or human health, and scientifically proven evidence of their efficacy is scarce. …”
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Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. This is achieved primarily by promoting apoptosis, reducing proliferation, and inhibiting metastasis. …”
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Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells by Jun Ying, Qinwen Ge, Songfeng Hu, Cheng Luo, Fengyi Lu, Yikang Yu, Taotao Xu, Shuaijie Lv, Lei Zhang, Jie Shen, Di Chen, Peijian Tong, Luwei Xiao, Ju Li, Hongting Jin, Pinger Wang

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NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity by Rui Ma, Zhenlong Li, Hejun Tang, Xiaojin Wu, Lei Tian, Zahir Shah, Ningyuan Liu, Tasha Barr, Jianying Zhang, Sean Wang, Srividya Swaminathan, Guido Marcucci, Yong Peng, Michael A. Caligiuri, Jianhua Yu

“…This can be reversed by injecting NKp46+ ILC1s into NKp46 knock-out mice. Human NKp46+ ILC1s exhibit stronger cytokine production and cytotoxicity than their NKp46− counterparts, suggesting that NKp46 plays a similar role in humans. …”
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Analysis of a Series of 26 Cases With Prenatal Skeletal Dysplasia via Multiplatform Genetic Detection by Li‐min Cui, Hua‐ying Hu, Xiao‐mei Zhai, Ming‐fei Qi, Yan‐ming Liu, Cong‐ying Han, Jing Zhang, Ming Shen, Yu‐lan Xiang, Wen‐qi Chen, Kai Yang, Dong‐liang Zhang, Huan‐xia Xing

“…ABSTRACT Background Skeletal dysplasia (SD) represents a series of highly heterogeneous congenital genetic diseases affecting the human skeletal system. Refined genetic diagnosis is helpful for the accurate diagnosis and prognosis evaluation of SDs. …”
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Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…The addition of ruxolitinib increases UCB-Treg cell persistence in peripheral blood in vivo and decreases the soluble form of human inflammatory cytokines including IFN-γ, TNF-α, and sCD40L in plasma along with improvement of skin lesions in SLE xenografts. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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Case of Superficial Cancer Located at the Pharyngoesophageal Junction Which Was Dissected by Endoscopic Laryngopharyngeal Surgery Combined with Endoscopic Submucosal Dissection by Kenro Kawada, Tatsuyuki Kawano, Taro Sugimoto, Kazuya Yamaguchi, Yuudai Kawamura, Toshihiro Matsui, Masafumi Okuda, Taichi Ogo, Yuuichiro Kume, Yutaka Nakajima, Andres Mora, Takuya Okada, Akihiro Hoshino, Yutaka Tokairin, Yasuaki Nakajima, Ryuhei Okada, Yusuke Kiyokawa, Fuminori Nomura, Takahiro Asakage, Ryo Shimoda, Takashi Ito

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Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…At the single-cell level, the WNT-LEF1 expression score was higher in tumor cells from both human hepatoblastoma samples and a hepatoblastoma patient-derived xenotransplant model; (4) Discussion: This study uncovered a shared transcriptional activation of a LEF1-dependent embryonic program, which orchestrates the regulation of the Wnt signaling pathway in tumor cells from both hepatoblastoma and medulloblastoma.…”
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Cross-sectional association among dietary habits, periodontitis, and uncontrolled diabetes in Hispanics: the LLIPDS study by Hunter Smith, David Travis Thomas, Gabriela Nicole Vázquez-Morales, Lakin Puckett, María Del Mar Rodriguez, Arnold Stromberg, Luciana Macchion Shaddox, Mauro Pedrine Santamaria, Kevin Pearce, Oelisoa Mireille Andriankaja

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