Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…Interleukin 10 (IL-10) is a synthetic inhibitor of human cytokines with immunomodulatory and anti-inflammatory effects. …”
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A new future for dog breeding by Helle Friis Proschowsky, Maja Louise Arendt, Brenda N Bonnett, Camilla S Bruun, Irena Czycholl, Merete Fredholm, Dan O’Neill, James A Serpell, Peter Sandøe

“…We argue that newly invented designer breeds and mixed breeds also have worrying health and behavioural problems, and that the predictability of purebred dogs with respect to body size, basic behaviours, known need for grooming, disorder profiles and other attributes may well offer some benefits for a satisfying human-dog relationship seen from both sides. The optimal future seems to lie in the middle ground, where the future organised dog world (i.e. kennel and breed clubs or their successor organisations) will need to re-open the breed registries, remove wording from breed standards that currently promotes extreme conformation, support selection against disease-predisposing genotypes and phenotypes and refocus dog showing and breeding to promote health and appropriate behaviour.…”
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Prevalence and determinants of persistent symptoms after infection with SARS-CoV-2: protocol for an observational cohort study (LongCOVID-study) by Lotte Haverman, Eelco Franz, Ka Yin Leung, Albert Jan Van Hoek, Hans Knoop, Cees C van den Wijngaard, Elizabeth N Mutubuki, Tessa van der Maaden, Albert Wong, Anna D Tulen, Siméon de Bruijn

“…Secondary outcomes include effect of vaccination prior to infection on persistent symptoms, loss of health-related quality of life (HRQoL) and risk factors for persisting symptoms following infection with SARS-CoV-2.Ethics and dissemination The Utrecht Medical Ethics Committee (METC) declared in February 2021 that the Medical Research Involving Human Subjects Act (WMO) does not apply to this study (METC protocol number 21-124/C). …”
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Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…Descriptive statistics, univariate and multivariate regression analysis will be conducted to identify the predictors of morbidity and clinical outcomes following infection.Ethics and dissemination The study has been approved by the CQHHS Human Research Ethics Committee (HREC) (reference number HREC/2021/QCQ/74305). …”
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Scenario Simulation of Ecosystem Services Based on Land Use/Land Cover Change in the Bailong River Basin, in China by Shuangying Li, Yanyan Zhou, Dongxia Yue, Zhongling Guo, Zhi Li

“…Studying LUCC and its impact on ESs is crucial for a comprehensive understanding of the impact of human activities on ecosystems. The InVEST model coupled with the predicted land use data were used to analyze the spatiotemporal characteristics of four ESs (soil conservation (SC), water yield (WY), carbon storage (CS), and habitat quality (HQ)) under three scenarios from 2040 to 2100 and quantified trade-offs/synergies and bundles of these ESs within the Bailong River Basin (BRB). …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…Our findings demonstrate the significant potential of geostationary satellite observations in artificial-intelligence-based air quality forecasting, with implications for early warning of air pollution events and human health exposure.</p>…”
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Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy by Jian Huang, Shuangna Song, Yihua Yin, Yinyan He, Huimin Wang, Ye Gu, Laman He, Xintao Wang, Xiaocao Miao, Zhigang Zhang, Xueli Zhang, Yiran Li, Yiran Li

“…Consequently, by constructing human leukocyte antigen (HLA) tetramers and incubating them with patients’ peripheral blood mononuclear cells (PBMCs), T cells capable of recognizing the POLEP286R mutation were sorted for further transcriptomic, proteomic and T-cell receptor (TCR) sequencing analyses and for an organoid EC model.ResultsTumor- and immune-related pathways were shown to be activated in the POLEP286R mutant group. …”
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Perception, Trust, and Motivation in Consumer Behavior for Organic Food Acquisition: An Exploratory Study by Elena Moroșan, Violeta Popovici, Ioana Andreea Popescu, Adriana Daraban, Oana Karampelas, Liviu Marian Matac, Monica Licu, Andreea Rusu, Larisa-Marina-Elisabeth Chirigiu, Sinziana Opriţescu, Elena Iuliana Ionita, Alina Saulean, Maria Nitescu

“…(1) Background: A sustainable healthy diet assures human well-being in all life stages, protects environmental resources, and preserves biodiversity. …”
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Snow depth estimation on leadless landfast ice using Cryo2Ice satellite observations by M. Saha, J. Stroeve, J. Stroeve, D. Isleifson, J. Yackel, V. Nandan, V. Nandan, J. C. Landy, H. M. Lam

“…<p>Observations of snow on Arctic Sea ice are vitally important for sea ice thickness estimation, bio-physical processes, and human activities. While previous studies have combined CryoSat-2- and ICESat-2-derived freeboards to estimate snow depth over Arctic sea ice, these approaches require leads within the ice pack to estimate the freeboard heights above the sea surface. …”
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ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma by Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Xuan Zhou, Zhi Xu, Fei Fei, Wei Song, Juan Li

“…The clinical significance of ALKBH5 and TIM3 were evaluated in human HCC tissues. The biological function of ALKBH5 was analyzed in vitro and in vivo. …”
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mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction by Seon-Yeong Lee, Jeonghyeon Moon, A Ram Lee, Young-Mee Moon, Jeong Won Choi, Chae Rim Lee, Su Been Jeon, Hee Su Sohn, Jeehee Youn, Dongyun Shin, Sung-Hwan Park, Mi-La Cho

“…The abnormal accumulation of autophagosomes and the expression of inflammatory cell death factors were also decreased in these mice. In mouse and human immune cells, ZnSO4, an inducer of mitochondrial STAT3, decreases the production of reactive oxygen species, the IL-17 concentration, and differentiation into Th17 cells. …”
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Technical efficiency of public hospitals in east Africa: a systematic review and meta-analysis by Anteneh Lamesgen, Bekalu Endalew, Aysheshim Belaineh Haimanot, Tigabu Kidie Tesfie, Elyas Melaku Mazengia, Mulat Belay Simegn, Werkneh Melkie Tilahun, Molla Yigzaw Birhanu, Lakew Asmare, Habtamu Geremew, Muluye Gebrie Mengie

“…Abstract Background Hospitals usually encounter human, capital, and financial resource constraints which alerts the efficient use of allocated resources more than ever. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…Intestinal human microbiota is a dynamic system that is under the pressures of its host organism and external factors. …”
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

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NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression by Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

“…We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. …”
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Performance evaluation of the smartphone-based AI cough monitoring app - Hyfe Cough Tracker against solicited respiratory sounds [version 2; peer review: 1 approved, 2 approved wit... by Isabel Blavia, Juliane Chaccour, Eric M. Keen, Virginia Orrillo, Mindaugas Galvosas, Matthew Rudd, Juan C. Gabaldón-Figueira, Simon Grandjean Lapierre, Carlos Chaccour, Peter M. Small, Gerard Giménez

“…Results: Hyfe Cough Tracker app showed sensitivity of 91% and specificity of 98% with a very high correlation between the cough rate measured by Hyfe and that of human annotators (Pearson correlation of 0.968). …”
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Threats of zoonotic pathogens in food chain: Current status and gaps in IndiaKey public health Message: by Madhuchhanda Das, Anup Kumar Ojha, Venencia Albert, Saradi Borah, Thandavarayan Ramamurthy, Samaresh Das, Tapan Kumar Dutta, Hosterson Kylla, Rajkumari Mandakini, Sarangthem Indira Devi

“…Increased human-animal interface, cross-species transmission of a few emerging pathogens, and dissemination of antimicrobial-resistant genes are major concerns. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…The use of submillimeter resolution functional magnetic resonance imaging (fMRI) is increasing in popularity due to the prospect of studying human brain activation non-invasively at the scale of cortical layers and columns. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…After analyzing Ly6E expression levels in human breast cancer tissues and tumor cell lines, we generated Ly6E knockout (KO) and overexpression (OE) mouse cell lines. …”
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Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

“…Gaining traction in this field is the use of disease data linking genes with pathological phenotypes and combining this with drugtarget interaction data.MethodsWe introduce methodology to associate drugs with effects, both intended and adverse, using a tripartite network approach that combines drug-target and target-phenotype data, in which targets can be represented as proteins and protein domains.ResultsWe were able to detect associations for over 140,000 ChEMBL drugs and 3,800 phenotypes, represented as Human Phenotype Ontology (HPO) terms. The overlap of these results with the SIDER databases of known drug side effects was up to 10 times higher than random, depending on the target type, disease database and score threshold used. …”
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