The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human cancers by modulating cell proliferation and death. …”
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MGScoliosis: Multi-grained scoliosis detection with joint ordinal regression from natural image by Xiaojia Zhu, Rui Chen, Zhiwen Shao, Ming Zhang, Yuhu Dai, Wenzhi Zhang, Chuandong Lang

“…Extensive experiments demonstrate that our approach outperforms state-of-the-art methods as well as human performance, which provides a promising and economical solution to wide-range scoliosis screening. …”
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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…To overcome those challenges a bispecific approach was taken. CC-96673, a humanized IgG1 bispecific antibody co-targeting CD47 and CD20, is designed to bind CD20 with high affinity and CD47 with optimally lowered affinity. …”
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Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer by Carlos Eduardo Salazar-Mejía, María Elena García-Gutiérrez, María Inés Contreras-Salcido, Carlos Javier Rodríguez-Álvarez, Blanca Otilia Wimer-Castillo, Jackeline Grace Lara-Campos, Edio Llerena-Hernández, José Luis González-Vela, David Hernández-Barajas

“…It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (β-hCG) and with a very poor prognosis, particularly in patients with β-hCG values above 50,000 IU/L. …”
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Good soil management can reduce dietary zinc deficiency in Zimbabwe by Muneta G. Manzeke-Kangara, Edward J. M. Joy, Florence Mtambanengwe, Prosper Chopera, Michael J. Watts, Martin R. Broadley, Paul Mapfumo

“…Abstract Background Dietary zinc (Zn) deficiency is widespread in sub-Saharan Africa (SSA) with adverse impacts on human health. Agronomic biofortification with Zn fertilizers and improved soil fertility management, using mineral and organic nutrient resources, has previously been shown to increase Zn concentration of staple grain crops, including maize. …”
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Association between gut microbiota and short-chain fatty acids in children with obesity by Shihan Li, Xinyu Ma, Hong Mei, Xuening Chang, Peiling He, Lingli Sun, Han Xiao, Shiqiong Wang, Ruizhen Li

“…The microbiota influences human metabolism via specific pathways, particularly butyrate, caproate, and the genus Oscillibacter, all closely associated with obesity.…”
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Musician’s dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments by Joy Grifoni, Joy Grifoni, Valeria Crispiatico, Anna Castagna, Rosa Maria Converti, Marina Ramella, Angelo Quartarone, Teresa L’Abbate, Teresa L’Abbate, Karolina Armonaite, Karolina Armonaite, Luca Paulon, Luca Paulon, Francescaroberta Panuccio, Franca Tecchio

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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

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Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…Additionally, LNP-M effectively delivered DNA-encoded antigens, such as mouse PD-L1 and p53R172H, or monoclonal antibodies targeting mouse PD1 and human p53R282W. This approach inhibited tumor growth or metastasis in several mouse models. …”
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Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash by Cristina Aguilera, Marco Viteri, Rachid Seqqat, Ligia Ayala Navarrette, Theofilos Toulkeridis, Ana Ruano, Marbel Torres Arias

“…Detailed studies about the impact of volcanic ash on human health are still lacking. Therefore, the disease of exposed populations is unknown. …”
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Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…In addition, 3T3-L1 cells were pretreated with IL-6, followed by recombinant human FGF21 (rhFGF21) treatment; lipolysis was assessed. …”
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Performance Evaluation of Large Language Models in Cervical Cancer Management Based on a Standardized Questionnaire: Comparative Study by Warisijiang Kuerbanjiang, Shengzhe Peng, Yiershatijiang Jiamaliding, Yuexiong Yi

“…Interpretability analysis showed that prompts improved alignment with human annotations for proprietary models (median intersection over union 0.43), while medical-specialized models exhibited limited improvement. …”
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Comparative analysis of the primary structure and production of recombinant poly(ADP-ribose)polymerase 1 of long-lived Heterocephalus glaber by K. N. Naumenko, A. R. Nurislamov, K. D. Nazarov, V. S. Fishman, A. A. Popov, I. O. Petruseva, A. N. Evdokimov, O. I. Lavrik

“…In the present work, the amino acid sequence of PARP1 of the naked mole rat is compared with the amino acid sequences of orthologous proteins of other mammals. In contrast to human PARP1, 13 evolutionarily conservative amino acid substitutions in various functional domains of the protein have been identified in the amino acid sequence of naked mole rat PARP1. …”
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Hobbit: Providing Fall Detection and Prevention for the Elderly in the Real World by Markus Bajones, David Fischinger, Astrid Weiss, Daniel Wolf, Markus Vincze, Paloma de la Puente, Tobias Körtner, Markus Weninger, Konstantinos Papoutsakis, Damien Michel, Ammar Qammaz, Paschalis Panteleris, Michalis Foukarakis, Ilia Adami, Danai Ioannidi, Asterios Leonidis, Margherita Antona, Antonis Argyros, Peter Mayer, Paul Panek, Håkan Eftring, Susanne Frennert

“…Our trials show the necessity to move out into actual user homes, as only there can we encounter issues such as misinterpretation of actions during unscripted human-robot interaction.…”
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Body mass index changes and predictors among adults living with HIV/AIDS who are on anti-retroviral therapy at Chiro General Hospital, Eastern Ethiopia: a facility-based retrospect... by Sintayehu Amsalu, Tara Wilfong, Sewmehon Amsalu, Abdu Oumer, Berhe Gebremichael

“…Abstract Background Human immunodeficiency virus continues to be a major global public health issue. …”
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A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction by Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier

“…ABSTRACT Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). …”
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Shanghai et Guangzhou sont les deux agglomérations urbaines les plus peuplées du monde by François Moriconi-Ebrard, Joan Perez

“…First, this paper explains why these significant population figures are not (and cannot be) official figures due to the official Chinese definition of a city which is in total opposition with the exploratory analysis approaches used in western human sciences and statistics. Second, it briefly explains the morphological definition and the methodology used in this research in relation to Chinese data availability. …”
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Sparse attention convolution-ViT model for working condition recognition in zinc flotation by Yue SU, Zhaohui TANG, Yongfang XIE, Xiaoliang GAO, Hu ZHANG, Weiye MA, Haiyang TANG

“…Traditionally, this recognition heavily relies on manual observations of froth appearance, a method prone to human error and subjective judgment. To address this issue and improve recognition accuracy, a sparse attention convolution-ViT model is proposed. …”
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Antioxidant, Anti-Tyrosinase, and Wound-Healing Capacities of Soy Protein Hydrolysates Obtained by Hydrolysis with Papaya and Cantaloupe Juices Showing Proteolytic Activity by Thi-Phuong Nguyen, Quang Thai Le, Mai Linh Thi Tran, Kim Nhung Ta, Khoa Thi Nguyen

“…Remarkably, the hydrolysates prepared from the hydrolysis with fruit juices accelerated the wound closure in human fibroblasts by estimately 1.5 times after 24 h of treatment while this property was not observed in the hydrolysate by papain. …”
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Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge by M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow, H.S. Virk

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