GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…RT-PCR assays were used to test the GRK6 expression in human BC tissues and cell lines. The in vitro cellular migration and in vivo lung colony-forming assays were established to estimate the metastatic potentials of TNBC cells. …”
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GLOBE Observer: A Case Study in Advancing Earth System Knowledge with AI-Powered Citizen Science by Peder V. Nelson, Russanne Low, Holli Kohl, David Overoye, Di Yang, Xiao Huang, Sriram Chellappan, Farhat Binte Azam, Ryan M. Carney, Monika Falk, Joan Garriga, Larisa Schelkin, Rebecca Boger, Theresa Schwerin

“…Citizen science and artificial intelligence (AI) complement each other by harnessing the strengths of both human and machine capabilities. Citizen science generates terabytes of raw numerical, text, and image data, the analysis of which requires automated techniques to process in an efficient manner. …”
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A Review of the Health Impact of Nicotine Pouches by Radosław Chmiel, Daria Michałka, Natalie Papachristoforou, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Natalia Tekiela, Emilia Bąk, Justyna Głowacka, Aleksandra Kocjan

“…The aim of this review is to summarize the current knowledge on the impact of nicotine pouches on overall human health.   Review Methods The review is based on 39 articles found in PubMed databases published between 2006–2024.  …”
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Wildfire danger under changing climates in the southern Great Plains throughout the 21st century by Shanmin Fang, Jia Yang, Chris B. Zou, Erik S. Krueger, Tyson E. Ochsner, Quan Zhang

“…The southern Great Plains (SGP) has recently experienced wildfires with unprecedented severity and frequency, which significantly threatened human life and property and altered terrestrial ecosystem functions. …”
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Bilateral Neuropathy of Primary Sensory Neurons by the Chronic Compression of Multiple Unilateral DRGs by Ya-Bin Xie, Huan Zhao, Ying Wang, Kai Song, Ming Zhang, Fan-Cheng Meng, Yu-Jie Yang, Yang-Song He, Fang Kuang, Si-Wei You, Hao-Jun You, Hui Xu

“…To mimic multilevel nerve root compression and intervertebral foramina stenosis in human, we established a new animal model of the chronic compression of unilateral multiple lumbar DRGs (mCCD) in the rat. …”
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male by Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa

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Marigold: a machine learning-based web app for zebrafish pose tracking by Gregory Teicher, R. Madison Riffe, Wayne Barnaby, Gabrielle Martin, Benjamin E. Clayton, Josef G. Trapani, Gerald B. Downes

“…Zebrafish embryos and larvae are ideal for such applications because they are spawned in large clutches, develop rapidly, feature a relatively simple nervous system, and have orthologs to many human disease genes. However, existing software for video-based behavioral analysis can be incompatible with recordings that contain dynamic backgrounds or foreign objects, lack support for multiwell formats, require expensive hardware, and/or demand considerable programming expertise. …”
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Investigation of the spatial and temporal long-term hydro-climatic trends in Upper Omo Gibe Basin, Ethiopia by Eyasu Tafese Mekuria, Tamene Adugna Demissie, Fekadu Fufa Feyessa

“…Human activities have changed hydroclimatic components worldwide, affecting agricultural productivity and water resources management. …”
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Performance, Carcass Traits and Meat Quality of Lambs Fed with Increasing Levels of High-Oleic Sunflower Cake by Daviane M. Costa, Tharcilla I. R. C. Alvarenga, Isabela J. dos Santos, Paulo C. G. Dias Junior, Flavio A. P. Alvarenga, Nadja G. Alves, Iraides F. Furusho-Garcia

“…Up to 450 g/kg DM of high-oleic sunflower cake in the diet of lambs did not affect animal performance while providing a higher deposition of fat with better fatty acid composition for human consumption.…”
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baran Luka Korban Kecelakaan Lalu Lintas yang Dilakukan Pemeriksaan di RSUP Dr. M. Djamil Padang by Isnu Lucky Riandini, Rika Susanti, Amel Yanis

“…<br />Kata kunci: kecelakaan lalu lintas, luka, VeR</p><p> </p><p>Abstract<br />Traffic accident is a condition involving vehicle or other street user, causing human victim or material loss. The objective of this study was to find the description of injuries to the victims of traffic accidents conducted an examination at RSUP Dr. …”
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Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…All the compounds were evaluated for antibacterial activities against Gram-positive and Gram-negative bacteria and mycobacteria. Cytotoxicity on human cells was also tested. Key results: Three compounds showed activity comparable to clinically used drugs. …”
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Eating "rubbish"? Exploring the herbal secrets of "Laji-He," a traditional herbal rice snack from southern China by Renchuan Hu, Qianyun Wang, Zhongxin Duan, Yunan Hu, Kedao Lai, Xiaohui Cai, Ya Peng, Binsheng Luo

“…This study aims to analyze the medicinal plant used in Laji-He and its implication in human medicine. Methods Ethnobotanical surveys and interviews were conducted in the Beibu Gulf region, covering local markets and communities. …”
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Stress-Driven Production of γ-Aminobutyric Acid Using Non-Conventional Yeast Strains <i>Kluyveromyces marxianus</i> JMY140K and <i>Metschnikowia reukaufii</i> JMY075 by Ting-Ting Fan, Chao Chen, Du-Wen Zeng, Feng-Lou Wang, Zhao-Xian Xu, Ming-Jie Jin, Yue Zou, Jun Li, Xin-Qing Zhao

“…The culture filtrate of <i>K. marxianus</i> JMY140K also showed promising activities in human skin cells. In addition, <i>K. marxianus</i> JMY140K could also produce GABA using rice straw hydrolysate, which indicated that it has the potential to produce GABA using renewable biomass. …”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600E ), which has attracted considerable attention in clinical trials for the treatment of human cancers. Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health by Yan Zuo, Zhilan Bai, Kaixuan Yang, Ziyuan Lin, Xiaolin Hu, Huaqin Sun

“…Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. …”
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The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…One of the recent promising methods of cAMR treatment is a recombinant humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody referred to as Tocilizumab (TCZ). …”
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Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis by Yuanyuan Ju, Chunhua Ma, Lin Huang, Yumei Tao, Tianqi Li, Haibo Li, Mark M. Huycke, Yonghong Yang, Xingmin Wang

“…Glutathione S-transferase alpha 4 (Gsta4), a specific detoxifying enzyme for 4-HNE, is overexpressed in human CRC and E. faecalis-induced murine CRC. However, the roles of Gsta4 in E. faecalis-induced colitis and CRC remain unclear. …”
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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparo... by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…All data will be analysed by intention to treat.Ethics and dissemination The study is approved by the Western Australia Health Central Human Research Ethics Committee (RGS0000006283). …”
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Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway by Gang Liu, Gang Liu, Bin-Bin Dong, Bin-Bin Dong, Zi-Heng Ding, Zi-Heng Ding, Chao Lan, Chang-Ju Zhu, Qi Liu, Qi Liu

“…Then, the inhibitors of PECAM-1, Src, STAT3 were adopted respectively, the effect on VILI, inflammation, the Src/STAT3 pathway, and pyroptosis was evaluated. In vitro, human umbilical vein endothelial cells (HUVECs) were used to validate the findings in vivo.ResultsUPLS activated PECAM-1, Src/STAT3 signaling pathway, inflammation, and pyroptosis in the VILI model with rats, whereas inhibition of PECAM-1 or the Src/STAT3 signaling pathway decreased lung injury, inflammatory responses, and pyroptosis. …”
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ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury by Xuechan Bi, Min Li, Yiming Guo, Mengyao Hu, Yujie Chen, Ni Lian, Sihan Chen, Min Li, Heng Gu, Xu Chen

“…We observed that the key molecules of GSDMD-mediated pyroptosis, apoptosis, and necroptosis, which are N-terminal GSDMD, cleaved caspase-3/PARP, and phosphorylated MLKL, respectively, were elevated in keratinocytes of UVB-challenged mice and human skin tissue. Through keratinocyte-specific gene knockout or using corresponding inhibitors, we found that individual inhibition of GSDMD-mediated pyroptosis, caspase-3-mediated apoptosis, or MLKL-mediated necroptosis did not reduce the overall level of keratinocyte death after UVB exposure, and that the other two pathways maintained the activation. …”
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