TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Background: Despite treatment advances for patients with early-stage triple-negative breast cancer (TNBC) and hormone receptor (HR)-low/human epidermal growth factor receptor 2-negative (HER2−) breast cancer, treatments that improve clinical outcomes while mitigating toxicity are needed. …”
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The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism by Ying Song, Xinyi Zhu, Beibei Wang, Qisong Li, Biwei Song

“…Abstract Skin, as the first line of defence of the human body, is exposed to dangers such as overheating substances, ultraviolet rays, and environmental pollutants, and the incidence of skin diseases is increasing annually. …”
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Evaluation for an Open Society: Then and Now by Robert Picciotto

“…The dominance of an international order grounded in democracy, human rights, and the rule of law is giving way to a world in which leaders are pursuing narrow nationalist and vested interests. …”
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Feline Papillomatosis by Herman Egberink, Katrin Hartmann, Ralf Mueller, Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Karin Möstl, Diane D. Addie, Corine Boucraut-Baralon, Tadeusz Frymus, Regina Hofmann-Lehmann, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Margaret J. Hosie

“…Besides cat-specific PVs, DNA sequences most closely related to human and bovine PVs have been detected in feline skin lesions. …”
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Sources of PM2.5 Oxidative Potential during Haze and Non-haze Seasons in Chiang Mai, Thailand by Pitakchon Ponsawansong, Tippawan Prapamontol, Kittipan Rerkasem, Somporn Chantara, Kraichat Tantrakarnapa, Sawaeng Kawichai, Guoxing Li, Cao Fang, Xiaochuan Pan, Yanlin Zhang

“…These results suggest that during haze episodes, higher levels of PM2.5 and its chemical compositions play a crucial role on OP, particularly DTTv activity, which may induce oxidative stress in human body.…”
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Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells by Francesco K. Touani, Melanie Borie, Feryel Azzi, Dominique Trudel, Nicolas Noiseux, Shant Der Sarkissian, Sophie Lerouge

“…Bone marrow MSCs from rat (rMSC) and human (hMSC) origin were preconditioned for 1 hour with celastrol 1 μM or vehicle (DMSO 0.1% v/v), then encapsulated within a chitosan-based thermosensitive hydrogel. …”
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Using Sequence Mining to Predict Complex Systems: A Case Study in Influenza Epidemics by Theyazn H. H. Aldhyani, Manish R. Joshi, Shahab A. AlMaaytah, Ahmed Abdullah Alqarni, Nizar Alsharif

“…Moreover, graver dangers are encountered with influenza subtypes against which there is little or no preexisting human immunity. Such subtypes of influenza have the potential to cause devastating epidemics. …”
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Derivation and Verification of the Relationship between Ablation Index and Baseline Impedance by Zheng Cai, Sainan Li, Qi Zhang, Chenyuan Wang, Zhen Jin, Ming Fu, Shuai Zhang, Ming Liang, Zulu Wang, Yaling Han

“…Under different baseline impedances and corresponding powers, the swine hearts were ablated for 30 s in simulated human circumstances. The baseline impedances, the lesion dimensions, and AIs were recorded. …”
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Evaluation of the impact of acidic medications and fluoride-containing mouthwash on the enamel surface using quantitative light-induced fluorescence, microhardness, and scanning el... by Saanya Bhasin, Simran Singh, Manuel Sebastian Thomas, Karuna Yarmunja Mahabala, Ramya Shenoy

“…Methods An in vitro experimental study was conducted on ninety-six healthy human posterior teeth. Forty-eight samples were tested for surface demineralization via quantitative laser fluorescence (QLF), and the other forty-eight samples were tested for enamel microhardness via a Vickers hardness tester. …”
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Ecdysone receptor strongly influences larval–pupal–adult transition and melanization in Tuta absoluta by Xiaodi Wang, Jiajia Wu, Jianyang Guo, Nianwan Yang, Fanghao Wan, Zhichuang Lü, Wanxue Liu

“…The overuse of traditional pesticides negatively affects both human health and the environment. RNA interference (RNAi), based on double-stranded RNA (dsRNA) induction, can be beneficial in the control of Tuta absoluta; one of the key points of using this technique is the selection of target genes. …”
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Climate change and the sustainable use of medicinal plants: a call for “new” research strategies by Olha Mykhailenko, Olha Mykhailenko, Banaz Jalil, Lyndy J. McGaw, Javier Echeverría, Marce Takubessi, Marce Takubessi, Michael Heinrich, Michael Heinrich

“…Climate change and human activities severely impact the viability of plants and ecosystems, threatening the environment, biodiversity, and the sustainable development of plant-based products. …”
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A scoping review on the obstacles faced by beta thalassemia major patients in Pakistan- Matter of policy investment by Ali Hussain Ansari, Saqib Hussain Ansari, Mubarak Jabeen Salman, Muhammad Usman Hussain Ansari, Rawshan Jabeen

“…These largely include hepatitis C, hepatitis B, and the Human immunodeficiency virus (HIV). TTIs impact the quality of life of these patients and their overall survival. …”
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Economic vs. ecological benefit for organic food: the role of perceived values in online consumer reviews by Hong Huo, Hong Huo, Junru Yao, Junru Yao, Qiutong Li, Qiutong Li, Rong Wu, Rong Wu, Chen Wang, Chen Wang, Dingyao Yu, Dingyao Yu

“…IntroductionWith the growing awareness of sustainable development, organic food has been favored by consumers due to its advantages in both human health and environmental sustainability. However, the economic and ecological values of organic food have been two factors that consumers weigh. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…Additionally, Sholl analysis revealed a reduction in dendritic branching and neuronal projection length in both mouse and human CLCN4 KD neurons. Finally, the decreased phosphorylation of SYNAPSIN and expression of PSD95 along with dendrite abnormalities were restored after Risperidone treatment. …”
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Effect of Different Cooking Methods on Lipid Content and Fatty Acid Profile of Red Mullet ( Mullus barbatus ) by Francesca Biandolino, Ermelinda Prato, Asia Grattagliano, Isabella Parlapiano

“…The n 3/ n 6 ratio (range 1.25–3.65) decreased significantly after cooking; however, it remained above the recommended values for a healthy human nutrition (1:5). The PUFA/SFA ratio was between 0.69 in fried and 1.02 in boiled fish, both being greater than those recommended by the WHO/FAO [2003]. …”
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Efficient method for identification of Escherichia coli strains isolated from various chicken (Gallus gallus domesticus) organs by V. P. Terletskiy, V. I. Tyshchenko, O. B. Novikova, E. D. Dzhavadov, I. Ya. Shakhtamirov, N. L. Adaev

“…Tracing of transmission routes and identification of pathogen sources are important issues in preventive measures aimed at controlling human and animal infectious diseases. A fast and accurate method for bacterial strain identification (genotyping) allows scientifically sound planning of preventive schemes. …”
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Profile in various organic soil depth shrimp pond, Tambak Inti Rakyat, Karawang by Yuni Puji Hastuti, Lena Novita, Tri Widiyanto, Iman Rusmana

“…During the 120 day maintenance period could be known that in all pond systems were used (traditional, semi-intensive, and intensive) the concentration of C-organic and organic-N on average was located in the bottom layer which is a layer of 10‒15 cm. The lack of human intervention from ground pond system, the more diverse the type and amount of organic material contained therein. …”
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A dataset of Antarctic ecosystems in ice-free lands: classification, descriptions, and maps by Anikó B. Tóth, Aleks Terauds, Steven L. Chown, Kevin A. Hughes, Peter Convey, Dominic A. Hodgson, Don A. Cowan, John Gibson, Rachel I. Leihy, Nicholas J. Murray, Sharon A. Robinson, Justine D. Shaw, Jonathan S. Stark, Mark I. Stevens, John van den Hoff, Jane Wasley, David A. Keith

“…Abstract Antarctica, Earth’s least understood and most remote continent, is threatened by human disturbances and climate-related changes, underscoring the imperative for biodiversity inventories to inform conservation. …”
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RETRACTED: Melanin Produced by Bordetella parapertussis Confers a Survival Advantage to the Bacterium during Host Infection by Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Fuminori Sugihara, Yasuhiko Horiguchi

“…ABSTRACT Bordetella parapertussis causes respiratory infection in humans, with a mild pertussis (whooping cough)-like disease. …”
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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

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