Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…We investigated, in vitro, their effect on human cells and in vivo in EAE. We found that the osteopontin cleavage plays a key role in the function of this cytokine and that the two fragments exert distinct effects both in vitro and in vivo. …”
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Israel and Migration of High Skilled Workforce: Brain Drain and the Possibility of Replenishing the Market with High-Quality Human Capital by D. A. Maryasis

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Determination of In Vitro Antimicrobial Activity of Five Sri Lankan Medicinal Plants against Selected Human Pathogenic Bacteria by Manikkuwadura Hasara Nethmini De Zoysa, Hasanga Rathnayake, Ruwani Punyakanthi Hewawasam, Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne

“…To determine the potential antimicrobial effects of ethanol, aqueous, and hexane extracts of five Sri Lankan medicinal plants against four human pathogens. Methods. Asparagus falcatus (tubers), Asteracantha longifolia (whole plant), Vetiveria zizanioides (roots), Epaltes divaricata (whole plant), and Coriandrum sativum (seeds) were used in the study. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Laminin 521 Stabilizes the Pluripotency Expression Pattern of Human Embryonic Stem Cells Initially Derived on Feeder Cells by Halima Albalushi, Magdalena Kurek, Leif Karlsson, Luise Landreh, Kristín Rós Kjartansdóttir, Olle Söder, Outi Hovatta, Jan-Bernd Stukenborg

“…Human embryonic stem (hES) cells represent an important tool to study early cell development. …”
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ADD C FOR CONTEXT: WHAT CAN LANGUAGE INSTRUCTORS FROM THE HUMANITIES CONTRIBUTE TORESEARCH IN FOREIGN LANGUAGE ACQUISITION? by Dror Abend-David, James Kusch

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Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells by Yazhou Long, Katrin Bundkirchen, Pascal Gräff, Christian Krettek, Sandra Noack, Claudia Neunaber

“…Due to their immunomodulatory and regenerative capacity, human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising in the treatment of patients suffering from polytrauma. …”
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Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans by Yi Tian, Haobo Li, Peiyu Liu, Jun-mei Xu, Michael G. Irwin, Zhengyuan Xia, Guogang Tian

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Human and entomological determinants of malaria transmission in the Lihir Islands of Papua New Guinea: A cross-sectional study. by Pere Millat-Martínez, Michelle Katusele, Bernadine Kasian, Elias Omera, Esther Jamea, Lina Lorry, Aina Casellas, Dan Ouchi, Chilaka Wali, Sylvia Raulo, Arthur Elizah, Peter Kaman, Absalom Dau, Muker Sakur, Lemen Kilepak, Siub Yabu, Nelson Koata, John Kave, Michael Toa, Christopher Urakusie, Charles Kongs, Frank Kisba, Moses Laman, Oriol Mitjà, William Pomat, Quique Bassat, Stephan Karl, Bàrbara Baro

“…There, we investigated human and vector factors influencing malaria transmission.…”
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Are humans by birth as wicked as the Heidelberg Catechism (3-11) holds? A dialogue between theology and modern sciences by P. Lampe

“…Studies discovered remarkable capacities of empathy and altruism already in young children of different cultures as well as in primates, suggesting that altruism is deep-rooted in common ancestors of humans and primates. However, humans encounter limits of their capacity for altruism especially when dealing with outsiders not belonging to their own group. …”
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Digital framework for georeferenced multiplatform surveillance of banana wilt using human in the loop AI and YOLO foundation models by Juan Jose Mora, Guy Blomme, Nancy Safari, Sivalingam Elayabalan, Ramasamy Selvarajan, Michael Gomez Selvaraj

“…Additionally, we incorporated Explainable AI techniques, such as Gradient-weighted Class Activation Mapping, to enhance model transparency and trustworthiness. Human in the Loop Artificial Intelligence was also utilized to enhance the ground level model’s predictions.…”
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Comparative Analysis of the Full-Length Genome Sequence of a Clinical Isolate of Human Parainfluenza Virus 4B by John A. Lednicky, Thomas B. Waltzek, Micah D. Halpern, Sara B. Hamilton

“…We are engaged in airborne transmission and epidemiology studies of respiratory pathogens, with particular interest in human parainfluenza virus type 4 (hPIV-4) and other lesser studied viruses. …”
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Characterization of Different Sources of Human MSCs Expanded in Serum-Free Conditions with Quantification of Chondrogenic Induction in 3D by Hugo Fabre, Maxime Ducret, Olivier Degoul, Jonathan Rodriguez, Emeline Perrier-Groult, Elisabeth Aubert-Foucher, Marielle Pasdeloup, Céline Auxenfans, Colin McGuckin, Nico Forraz, Frédéric Mallein-Gerin

“…This work represents the first comparison of detailed immunophenotypic analysis and chondrogenic differentiation potential of human BM-, WJ-, DP-, and AT-MSCs performed under the same serum-free conditions, from their isolation to their induction. …”
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Enhanced Healing of Diabetic Wounds by Subcutaneous Administration of Human Umbilical Cord Derived Stem Cells and Their Conditioned Media by Chandrama Shrestha, Liling Zhao, Ke Chen, Honghui He, Zhaohui Mo

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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

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HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes by Irma Colombo, Enrico Sangiovanni, Roberta Maggio, Carlo Mattozzi, Stefania Zava, Yolanda Corbett, Marco Fumagalli, Claudia Carlino, Paola Antonia Corsetto, Diletta Scaccabarozzi, Stefano Calvieri, Angela Gismondi, Donatella Taramelli, Mario Dell’Agli

“…Cultured primary human keratinocytes are frequently employed for studies of immunological and inflammatory responses; however, interpretation of experimental data may be complicated by donor to donor variability, the relatively short culture lifetime, and variations between passages. …”
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Employee retention through effective human resource management practices in Maldives: Mediation effects of compensation and rewards system by Zubair Hassan

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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton by Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood

“…TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. …”
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The Effect of Gentle Handling on Depressive-Like Behavior in Adult Male Mice: Considerations for Human and Rodent Interactions in the Laboratory by Caroline Neely, Christina Lane, Julio Torres, Jane Flinn

“…Researchers, lab assistants, and husbandry staff in animal facilities may use inconsistent handling methods when interacting with rodents, but humans should be considered a part of the animal’s social environment. …”
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Characterization and Study of Gene Expression Profiles of Human Periodontal Mesenchymal Stem Cells in Spheroid Cultures by Transcriptome Analysis by Takenori Suga, Michihiko Usui, Satoru Onizuka, Kotaro Sano, Tsuyoshi Sato, Kohji Nakazawa, Wataru Ariyoshi, Tatsuji Nishihara, Keisuke Nakashima

“…This study is aimed at identifying genes specifically expressed in spheroid-cultured human periodontal ligament mesenchymal stem cells (hPDLMSCs) using RNA-seq analysis to evaluate their functions. …”
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